CH.5 Flashcards
if a cell were to make copies of itself what is that called
proliferation
what 2 cells does a multipotent SC differentiate into
myeloid and lymphoid
what is the 1st stage of a normoblast
multipotent SC
what is the 2nd stage of a normoblast
pronormoblast
what is the 3rd stage of a normoblast
basophilic normoblast
what is the 4th stage of a normoblast
polychromatophilic normoblast
what is the 5th stage of a normoblast
orthochromic normoblast
what is the 6th stage of a normoblast
shift reticulocyte
what is the 7th stage of a normoblast
reticulocyte
what is the 8th stage of a normoblast
erythrocyte
if a multipotent SC becomes a pronormoblast what does that tell you about that cell’s fate
it will become a RBC
can a basophilic normoblast go back to the pronormoblast stage
no
what is the last stage of proliferation for a normoblast
polychromatophilic normoblast
T or F: younger cells will be larger
T
T or F: the nucleus will be smaller in younger cells
F
T or F: chromatin pattern is diffused in young cells
T
T or F: younger cells will have nucleoli
T
T or F: reticulocytes are not basophilic
F
is RNA basic or acidic
acidic
what are the 2 erythroid progenitors
burst-forming unit-erythroid (BFU-E) and Colony-forming unit-erythroid (CFU-E)
what is the 1st stage of a erythroid that you can see in a microscope
pronormoblast
T or F: orthochromic normoblast have a nucleus
T
how long does it take for reticulocyte to brake down all nucleonic RNA
48 hrs
how long does it take for a SC to become a RBC
21 Days
what is the American name for an immature RBC
normoblastic
what is the british name for an immature RBC
erythroblast
what is the european name for an immature RBC
rubriblast
T or F: if a RBC needs to make more hemoglobin after it is mature it can
F
when does a RBC stop producing hemoglobin and enzymes
after they lose their nucleus
what does not stain in a pronormoblast
Golgi body and RNA
what do they call the areas that do not stain in a pronormoblast
hof
what kind of chromatin do basophilic normoblast have
cobble stone pattern
what color is the cytoplasm of a polychromic normoblast
pinkish
what is the function of the nucleus in the orthochromic normoblast stage
nothing, it is shut down
what is the blueish color of reticulocytes on a wright stain called
polychromasia
just using wright stain is sufficient enough to confirm reticulocytes? if not how do you confirm?
no; they also need to be stained with methylene blue
what does methylene blue stain in reticulocytes
RNA
what controls the production of RBCs
erythrokinetics
what is a stimulent of erythropoiesis
hypoxia
def? a state in which oxygen is not available in sufficient amounts at the tissue level to maintain adequate homeostasis
hypoxia
what organ releases erythropoietin
kidneys
T or F: erythropoietin inhibits apoptosis
T
what would be the level of erythropoietin in females at the end of their period
high
how long does a RBC live
120 days
what happens to the 10-15% of erthroid precursors that never mature
they are destroyed
is extra or intra vascular hemolysis more common
extravascular
what kind of erythrocyte destruction happens in the organs such as the spleen or liver
extravascular
what kind of erthrocyte destruction happens within the blood vessel
introcascular hemolysis
what is cellularity
ratio of myloid cells to fat cells in bone marrow
what does it mean if someone has 20% cellularity
20 myeloid cells to 80 fat cells
