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HEMOTOLOGY > CH.5 > Flashcards

CH.5 Flashcards

1
Q

if a cell were to make copies of itself what is that called

A

proliferation

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2
Q

what 2 cells does a multipotent SC differentiate into

A

myeloid and lymphoid

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3
Q

what is the 1st stage of a normoblast

A

multipotent SC

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4
Q

what is the 2nd stage of a normoblast

A

pronormoblast

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5
Q

what is the 3rd stage of a normoblast

A

basophilic normoblast

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6
Q

what is the 4th stage of a normoblast

A

polychromatophilic normoblast

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7
Q

what is the 5th stage of a normoblast

A

orthochromic normoblast

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8
Q

what is the 6th stage of a normoblast

A

shift reticulocyte

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9
Q

what is the 7th stage of a normoblast

A

reticulocyte

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10
Q

what is the 8th stage of a normoblast

A

erythrocyte

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11
Q

if a multipotent SC becomes a pronormoblast what does that tell you about that cell’s fate

A

it will become a RBC

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12
Q

can a basophilic normoblast go back to the pronormoblast stage

A

no

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13
Q

what is the last stage of proliferation for a normoblast

A

polychromatophilic normoblast

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14
Q

T or F: younger cells will be larger

A

T

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15
Q

T or F: the nucleus will be smaller in younger cells

A

F

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16
Q

T or F: chromatin pattern is diffused in young cells

A

T

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17
Q

T or F: younger cells will have nucleoli

A

T

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18
Q

T or F: reticulocytes are not basophilic

A

F

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19
Q

is RNA basic or acidic

A

acidic

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20
Q

what are the 2 erythroid progenitors

A

burst-forming unit-erythroid (BFU-E) and Colony-forming unit-erythroid (CFU-E)

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21
Q

what is the 1st stage of a erythroid that you can see in a microscope

A

pronormoblast

22
Q

T or F: orthochromic normoblast have a nucleus

A

T

23
Q

how long does it take for reticulocyte to brake down all nucleonic RNA

A

48 hrs

24
Q

how long does it take for a SC to become a RBC

A

21 Days

25
Q

what is the American name for an immature RBC

A

normoblastic

26
Q

what is the british name for an immature RBC

A

erythroblast

27
Q

what is the european name for an immature RBC

A

rubriblast

28
Q

T or F: if a RBC needs to make more hemoglobin after it is mature it can

A

F

29
Q

when does a RBC stop producing hemoglobin and enzymes

A

after they lose their nucleus

30
Q

what does not stain in a pronormoblast

A

Golgi body and RNA

31
Q

what do they call the areas that do not stain in a pronormoblast

A

hof

32
Q

what kind of chromatin do basophilic normoblast have

A

cobble stone pattern

33
Q

what color is the cytoplasm of a polychromic normoblast

A

pinkish

34
Q

what is the function of the nucleus in the orthochromic normoblast stage

A

nothing, it is shut down

35
Q

what is the blueish color of reticulocytes on a wright stain called

A

polychromasia

36
Q

just using wright stain is sufficient enough to confirm reticulocytes? if not how do you confirm?

A

no; they also need to be stained with methylene blue

37
Q

what does methylene blue stain in reticulocytes

A

RNA

38
Q

what controls the production of RBCs

A

erythrokinetics

39
Q

what is a stimulent of erythropoiesis

A

hypoxia

40
Q

def? a state in which oxygen is not available in sufficient amounts at the tissue level to maintain adequate homeostasis

A

hypoxia

41
Q

what organ releases erythropoietin

A

kidneys

42
Q

T or F: erythropoietin inhibits apoptosis

A

T

43
Q

what would be the level of erythropoietin in females at the end of their period

A

high

44
Q

how long does a RBC live

A

120 days

45
Q

what happens to the 10-15% of erthroid precursors that never mature

A

they are destroyed

46
Q

is extra or intra vascular hemolysis more common

A

extravascular

47
Q

what kind of erythrocyte destruction happens in the organs such as the spleen or liver

A

extravascular

48
Q

what kind of erthrocyte destruction happens within the blood vessel

A

introcascular hemolysis

49
Q

what is cellularity

A

ratio of myloid cells to fat cells in bone marrow

50
Q

what does it mean if someone has 20% cellularity

A

20 myeloid cells to 80 fat cells

HEMOTOLOGY (6 decks)

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