Ch49 - Intracellular Traffic And Sorting Of Proteins

Question 1

What is the targeting sequence or compound for the ER?

Answer 1

N-terminal signal peptide

Question 2

Targeting sequence for mitochondrial matrix

Answer 2

Amino terminal sequence

Question 3

Proteins for constitutuve secretion are carried by

Answer 3

Transport vesicles

Question 5

Where are proteins synthesized?

Answer 5

Polyribosomes

Question 6

Pathway in whihch proteins are directed to mitochondria, nuclei, and peroxisomes by specific signals

Answer 6

Cytosolic polyribosomes

Question 7

Terageting sequence for the lumen if ER

Answer 7

Carboxyl-terminal KDEL sequence (Lys-Asp-Glu-Leu) in COPI vesicles

Question 8

proposed that proteins synthesized in membrane-bound polyribosomes contain N-terminal signal peptide while it is absent in free polyribosomes

Answer 8

Signal hypothesis (Blobel and Sabatini)

Question 10

Targeting sequence for nucleus

Answer 10

NLS

Question 11

Targeting sequence for golgi membranes

Answer 11

Diacidic sequences in membrane proteins in COPII vesicles

Question 12

According to this, all ribosomes have the same structure

Answer 12

Signal hypothesis

Question 13

It is where specific proteins are synthesized

Answer 13

Cytosolic/free or membrane-bound polyribosomes

Question 15

Proteins for export from the cell via exocytosis are synthesized via this route

Answer 15

RER branch

Question 16

Proteins for regulated secretion are carried by

Answer 16

Secretory vesicles

Question 17

GA (TGN)

Answer 17

Trans-Golgi network

Question 19

Proteins that contain a targeting sequence that is subsequently removed

Answer 19

Preprotein

Question 20

part of the GA being as membrane stacks

Answer 20

Medial and trans-cisternae

Question 22

In this pathway, proteins are transported from ER-GA-PM and released to the outside environment

Answer 22

Secretory or exocytotic pathway

Question 23

Proteins that stabilize unfolded or partially folded proteins

Answer 23

Chaperones

Question 24

Most chaperones exhibit this activity and bind ATP and ADP. This activity is important for their effect on protein folding

Answer 24

ATPase activity

Question 25

Involved in processing of oligosaccharide chains and sorting of proteins

Answer 25

Golgi Apparatus

Question 26

Part of the GA facing the ER

Answer 26

cis-

Question 27

Targeting sequence for lysosome

Answer 27

Mannose-6-phosphate

Question 29

Targeting sequence for peroxisome

Answer 29

PTS

Question 30

Protein that has a targeting sequence that is removed together with a second peptide

Answer 30

Preproprotein