CH4(lec3) Histology Flashcards
Histology
The study of tissues
4 Type of Tissue
Epithelial 2)connective 3) muscles 4)nervous
Epithelial Tissue Functions
Protection; selective permeability; secretion; sensations
Cellularity Epithelial
Lots of cell (can look like one layer)
avascularity
Lack of blood supply
Characteristics of epithelial tissue(6)
Has cellularity 2) Polarity 3) Attaches to basement membrane 4) Avascularity 5) Innervation 6) High regenerative/reproduce capacity
Structure of Epithelial Tissue
1) Rest on Connective tissue and on top of basement membrane
Apical surface
Free surface
Basal surface
Attachment deeper
Basement Membrane components in order top to bot
Basal lamina and Reticular Lamina
Type of intercellular Junctions
1) Tight junctions 2) adhering junction 3) desmosomes 4) Gap junctions
Tight Junctions Characteristics
Held together Very closely 2) cells attach via membrane proteins at APICAL surface
Adhering junction
1) Has a adhesion belt 2) Deep to tight junction 3) Not as close as tight junction
Desmosomes
Made from Micro proteins and intermediate filaments anchored into PLAQUE only at a stress point
Hemidesmosomes
Half - desmosome - attached to the basement membrane
Gap junction
Gap is formed between cells by proteins called CONNEXONS(6 connexons form a pore between cells and allow for RAPID communication between adjacent cells (IE heart so it contracts at the same time)
Simple vs Stratified vs Pseudo stratified (epithelial cells)
Simple - 1 layer Stratified more than on layer or Pseudostratrified looks stratified but it is not
4 Shape of epithelial
Squamous 2) cuboidal 3) columnar 4) Transitional
Which cells do we make classification of shape on
Outermost
Squamous shape
Flat; Wide
Cuboidal shape
Similar height & width
Columnar shape
Taller than wide
Transition shape
Changes shape
Simple Squamous Epithelium is Found in
LUNGS; lining of alveoli; blood vessels(endothelium) serous cavities(mesothelium)
Simple Cuboidal Epithelium Found where
Kidney tubules
Simple Columnar Epithelium(non-ciliated) Found where and properties
In the digestive tract has microvilli (brush border) can have goblet cells
Stratified Squamous Epithelium Properties and Types
Outer layer is flat other layers are cuboidal or columnar. The basal layer has stem cells(can rapidly divide) Keratin and Non keratinized(protective protein)
Stratified Squamous Epithelium (keratinized) Location/Properties
Epidermis(outer layer skin) outer cell fill with keratin and die flaking off (dry)(color change and space)
Stratified Squamous Epithelium (non-keratinized) Property and location
No keratin cells are moist found in Oral cavity; pharynx; esophagus(slide); vagina(no color change or space)
Stratified Cuboidal Epithelium Location
Rare in Male urethra
Stratified Columnar Epithelium
Rare in Male urethra
Pseudostratrified Columnar Epithelium Location Properties
respiratory track; all cell touch basement membrane but not all cell reach apical surface can be ciliated or non ciliated
Pseudostratrified Columnar Epithelium (Ciliated) Location Properties
Respiratory track; PHARYNX has goblet cells(mucus)
Transition Epithelium Properties and Location
Outer surface is a dome shaped(stretched) Found in Urinal Bladder; ureters(kidney)
Glandular Epithelium Types and main differences
Exocrine and Endocrine glands (exocrine have duct and acinus(secretory portion)
Endocrine Glands
Lack ducts and secrete their products directly into the interstitial fluid and bloodstream. The excretions of endocrine glands; called hormones
Exocrine Glands
Typically originate from an invagination of epithelium that burrows into the deeper connective tissues. These glands usually maintain their contact with the epithelial surface by means of a DUCT an epithelium-lined tube through which secretions of the gland are discharged onto the epithelial surface. This duct may secrete materials onto the surface of the skin (e.g.; sweat from sweat glands)
Glandular Epithelium Structure
Unicellular(1 cell) (goblet cells) or multicellular
4 Types of multicellular Glandulars
They have duct and secretory portion 1) Simple(ducts dont branch) 2)Compound(ducts branch) 3) Tubular 4) Acinar(flask shaped
Merocrine (eccrine) Glandular Function
Secretory vesicles release their contents via EXOCTOSIS
Holocrine Glandular Function
Disintegrating cells with contents becoming the secretion( cells dies releases secretion
Apocrine Glandular Function
Pinching off a apical (top) portion cause explosion of apical surface to release contents(TITS)
Characteristics of Connective Tissues
They have cells; extracellular matrix( protein; ground substance). They are found deep and are highly vascular
Three types of Fibers found in Connective Tissues
1) Elastic Fibers 2) Collagen Fibers 3) Reticular Fibers
Three Main classifications of Connective Tissue
Connective Tissue Proper 2) Supporting Connective Tissue 3) Fluid Connective tissue
Types and subtypes of CT proper
1) Loose (areolar; adipose; Reticular) 2) Dense(dense regular; dense irregular; Elastic)
Types and sub-types of Supporting CT
1) Cartilage(Hyaline; Elastic cartilage; Fibrocartilage) 2)Bone (compact and spongy)
Types and sub-types of Fluid CT
1) BLOOD(RWC; WBC; Platelets)
Embryonic CT aka
Mesenchyme (source of all other CT
Resident Cells of the Connective Tissue Proper
Most Common cell are FIBROBLASTS(secrete EC matrix); 2) Fixed macrophages(phagocytize) 3) adipocytes(store fat) Mesenchymal cells(stem cells)
Wandering cells of the Connective Tissue Proper
1)Mast cells(secrete histamin and heparin(blood thinner))(test) 2)Plasma cells(secrete antibodies 3)Free Macrophages(phagocytize) 4)leukocytes(white blood cells; immunity)
Characteristics of Collagen Fibers
1) Most Common 2) Made of Collagen 3) Strong resistance to stretch(iron bar)
Characteristics of Elastic Fibers
1) Stretches 2) Made of elastin 3) elastic properties
Characteristics of Reticular Fibers
1) Not Common except in lymphatic organs (SPLEEN) 2)touch flexible; supporting framework(stroma)
Ground Substance of Connective Tissue Proper
Fluid; Gel like or solid
Areolar (type/char/location)
T: Loose CT(proper) C: Loosely organized collagen and elastic fibers has all cell types and liquid Ground substance. L: all over body
Adipose (type/char/location)
1) Loose CT(proper) C: Has adipocytes(fat cells(white/yellow)) and store triglycerides L:under skin hypodermis
Reticular(type/char/location)
1) Loose CT(proper) C: Reticular Fibers; fibroblasts; leukocytes L: Found in lymphatic Organs (SPLEEN)
Dense Regular (type/char/location)
1) Dense CT(CT Proper) C: Parallel COLLAGEN(test) fibers; Strong L: Tendons and ligaments
Dense Irregular (type/char/location)
T: Dense CT(Proper CT) C: irregularly arrange COLLAGEN Fibers provide support in many directions. F: dermis of the skin
Elastic CT Proper (type/char/location)
T: Dense CT (CT proper) C: Elastic fibers and Fibroblasts L: AORTA(test)
Cartilage Supporting Connective Tissue Characteristics (5)
Cartilage 1) Has a gel-like extracellular matrix 2) Chondrocytes (cells name) 3) Lacunae cells with a chondrocyte 4) Avascular 5) Some have a Perichondrium(outer layer)
Chondrocytes
Cartilage Cells
Cells specific to supportive tissues (4)
1) Chondrocytes 2) Lacunae with Chondrocytes(3) 4) Perichondrium
Hyaline Characteristics
Supporting CT(cartilage) most common and weakest. Made from non visible collagen fibers and has a perichondrium.
Where is Hyaline Found
End of long bones; nose; ribs
Fibrocartilage Characteristics
Supporting Connective Tissue(cartilage) ;Strongest made with irregularly arranged collagen fibers has no perichondrium(SLIDE looks bright blue)
Fibrocartilage Found?
Intervertebral discs; pubic symphysis
Elastic Cartilage Characteristics
Supporting Connective Tissue; Made from Elastic Fibers and has a perichondrium(Slide has fibers but not bright blue)
Elastic Cartilage Found?
External Ear and EPIGLOTTIS ( B4 lung prevent food from entering)
Bone Supporting Connective Tissue Characteristics (5)
1)Solid extracellular matrix 2) Collagen fibers(make Strong) 3 Calcium phosphate(make hard) 4) Osteocytes 5) Periosteum 6)Its Strong
What make bone strong and hard(t)
Collagen fibers(strong) and Calcium phosphate(hard)
Characteristics of Spongy Bone
Supporting CT; Has spaces in it and INTERIOR of most bones EXTRA (Trabeculae lattice shape)
Cells name of Compact Bone 5
1) Osteons(whole unit) 2) Lamellae (the rings) 3) Haversion canal(central canal) 4) Lacunae with Osteocyte inside(like elongated nucleus) 5) Canaliculi (canals going across rings)
Fluid Connective tissue charateristics
BLOOD formed from 3 elements:1) Erythrocytes(RBC) 2)Leukocytes(WBC) and Thrombocytes(platelet) in plasma
Muscle Tissue Characteristics (2)
1) Cells are called Fibers 2) Contractility
3 Types of muscle Tissue and location
1)Skeletal (attach to bones) 2) Cardiac(heart) 3) Smooth (blood vessels and small intestine/gastrointestinal tract)
Skeletal Muscle Tissue Characteristics
1) multinucleated 2) Has striated Stripes 3) Voluntary (we control)
Skeletal Muscle Location/Function
Attached to bones so we can move
Cardiac Muscle Tissue Characteristics
1) 1-2 nuclei 2) Striated(can’t see it always) 3) Involuntary 4) Branched Fibers 5) intercalated discs( perpendicular to fibers)
Where is cardiac muscle Found
Heart
Where are intercalated discs and what do they do?
IN cardiac Muscle tissue and provide cell to cell junction(from gap junction/desmosomes connection) allowing simultaneous contractions
Smooth Muscle Tissue Characteristics
1) ONE nucleus 2) Non-striated 3) involuntary 4) Fusiform appearance(squished alien spaceship)
Smooth Muscle Tissue Found?
Blood vessels and digestive system(GI track; Small Intestines)
Nervous Tissue Characteristics
1)Main Type called Neuron 2)Send electrical impulses(action potentials) 3)Soma(cell body) 4) Dendrites(receive info) 4) Axon sends out info
Dendrites vs Axon
Dendrites receive info and Axon send out info