Ch1: Menopause

Question 1

Early menopause:
Menopause that occurs before age…
Incidence?

Answer 1

Before age 45, but after age 40

3-5%

Question 2

Late menopause:

Menopause that occurs after age…

Answer 2

After age 54

Question 3

Early menopause transition:
What stage?
Intermenstrual irregularity of…
Levels of FSH, AMC and AFC…

Answer 3

Stage -2
Persistent difference of >7d in length of consecutive cycles
Elevated but variable FSH
Low AMH and AFC

Question 4

Late menopause transition:
What stage?
Intermenstrual irregularity of…
Levels of FSH, AMC and AFC…

Answer 4

Stage -1
>60 or more consecutive days of amenorrhea
FSH>25
Low AMH, AFC

Question 5

Early postmenopause:
What stage?
Time span?
Levels of FSH and E2...
Symptoms

Answer 5

Stage +1
First 2 years
FSH continues to rise and stabilize
E2 continues to decrease and stabilize
Vasomotor symptoms

Question 6

Late postmenopause:
What stage?
Time span?
Levels of FSH and LH...
Symptoms

Answer 6

Stage +2
5-8 years after FMP
Elevated FSH and LH
Urogenital atrophy

Question 7

Recommended HT for POI

Answer 7

100 mcg transdermal estradiol patch
1.25 mg CEE
2 mg estradiol
Cyclical progestogen added for 12 days of the month

Question 8

Primary ovarian insufficiency

Answer 8

Women aged younger than 40y
1% incidence
25% will experience at least one spontaneous return of ovarian function
5-10% pregnancy rate