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Pharm ATI > Ch 8- Depressive Disorders > Flashcards

Ch 8- Depressive Disorders Flashcards

1
Q

SSRIs

A

Fluoxetine (Prozac)

Citalopram (Celexa)
Escitalopram (Lexapro)
Paroxetine (Paxil)
Sertraline (Zoloft)
Vilazodone (Viibryd)
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2
Q

SSRIs adverse effects

A

Sexual dysfunction

CNS stimulation (inability to sleep, agitation, anxiety)

Weight loss early in therapy

Serotonin syndrome (2-72 hrs)

Hyponatremia

Sleepiness, faintness, lightheadedness

GI Bleeding

Bruxism

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3
Q

Serotonin syndrome

A 
Mental confusion
Fever
Agitation
Anxiety 
Hallucinations
Incoordination
Diaphoresis 
Tremors
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4
Q

SSRIs withdrawal syndrome

A 
Headache
Nausea
Visual disturbances
Anxiety
Dizziness
Tremors
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5
Q

SSRIs interactions

A

MAOIs, TCAs, St. John’s worst increase serotonin syndrome

Fluoxetine increase warfarin levels

Fluoxetine increase levels of tricyclics antidepressants and lithium

Increased bleeding with NSAIDs

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6
Q

Atypical antidepressants

A

Bupropion HCL (Wellbutrin)

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7
Q

Atypical antidepressants adverse effects

A 
Headache
Dry mouth
GI distress
Consitipation
Tachycardia
Nausea
Restlessness
Insomnia

Suppress appetite -weight loss

Seizures

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8
Q

Atypical antidepressants interactions

A

Phenelzine with MAOIs increase toxicity

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9
Q

Tricyclic antidepressants (TCAs)

A

-ine

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10
Q

TCAs adverse effects

A

Orthostatic hypotension

Anticholinergic effects

Sedation

Seizure

Excessive swearing

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11
Q

Anticholinergics effects

A 
Dry mouth
Blurred vision 
Photophobia
Urinary retention
Constipation
Tachycardia
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12
Q

Monoamine reuptake inhibitors (MAOIs)

A

Phenelzine (Nardil)

Isocarboxid (Marplan)
Tranylcyromine (Parnate)
Selegiline (Emsam) transdermal

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13
Q

MAOIs adverse effects

A

CNS stim (anxiety, agitation, mania)

Orthostatic hypo

Hypertension

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14
Q

Nursing admin therapeutic effects

A

1-3 weeks

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15
Q

Nursing admin full therapeutic effects

A

2-3 mo

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16
Q

SSRIs admin

A

am

With food

Older adults: sodium levels if on diuretics

17
Q

Seasonal use of atypical antidepressants

A

Begin in autumn and taper dose and discontinue by spring

18
Q

MAOIs foods to avoid

A

Tyramine (hypertensive crisis)

Yeast

Ex. Banana bread

19
Q

Tyramine foods

A 
Aged cheeses
Smoked or preserved fish or meats 
Avocado
Figs
Bananas
Protein dietary supps
Soups with meat extracts
Soy sauce
Some beers
Red wine

Pharm ATI (17 decks)

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