Ch 31- Meds Affecting Rep Tract Flashcards
Estrogens adverse effects
Endometrial and ovarian cancers
Estrogen- dependent breast cancer
MI, pulmonary embolism, DVT, stroke
Estrogen interactions
Estrogens reduce warfarin
Phenytoin/Dilantin decreases estrogen
Corticosteroids increase estrogen
Progesterones adverse effects
Breast cancer
Thromboembolic events
Edema
Jaundice
Migraine
Progesterone interactions
Carbazdpine (Tegretol), phenobarbital, phenytoin (Dilantin), rifampin decrease contraceptive effectiveness
Use with Bromocriptine (parlodel) can cause amenorrhea
Hormonal contraceptives adverse effects
Thromboembolic events
Hypertension
Breakthrough or abnormal uterine bleeding
Breast cancer
Hormonal contraceptives interactions
Effects decrease with carbamazepine (Tegretol), phenobarbital, antibiotics, penicillins, cephalosporins, phenytoin (Dilantin), rifampin
Contraceptives decrease effects of warfarin and hypoglycemics
Androgens adverse effects
Premature closure of epiphyseal
Cholestatic hepatitis, jaundice
Hypercholesterolemia
Increase prostate cancer
Polycythemia
Edema
High abuse potential
Deepening of voice, etc women
Androgen interactions
Oral anticoagulant
Insulin’s
Anti diabetic agents
Hepatotoxicity
5-alpha reductase inhibitors adverse effects
Decreased libido
Gyemcomastia
Ortho hypo
5-alpha reductase inhibitors use
Decrease usable testosterone
Reduce prostate
Increase hair growth
5-alpha reductase inhibitors interactions
Cimetidine decrease tamsulosin clearance
Antihypertensives
Nitro
Phosphodieterase type 5 (PDE5) adverse effects
MI
Sudden death
Priapism (erection longer than 4 hr)
Phosphodieterase type 5 (PDE5) interactions
Organic nitrates (nitrostat and isordil)
Katoconazole, erythromycin, cimetidine, ritonavir, grapefruit juic inhibit metabolism of sildebafil
