Ch. 8 Cardiology Flashcards
Etiology of CHF
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Congenital
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Increased pulm. blood flow
- Large VSD
- Large PDA
- Transposition of great arteries
- Truncus arteriosus
- Total anamalous pulmonary venous return
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Obstructive lesions
- Severe aortic, pulmonary, mitral valve stenosis
- Coarctation of aorta
- Hypoplastic L heart syndrome
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Other causes
- AVM
- Mitral or tricuspid regurgitation
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Increased pulm. blood flow
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Acquired
- Viral myocarditis
- Other cardiac infections (e.g., endocarditis, pericarditis), metabolic diseases (e.g., hyperthyroidism), medications (e.g., doxorubicin), cardiomyopathies, ischemic diseases
- Dysrhythmias (tachycardia and bradycardia)
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Miscellaneous
- Severe anemia –> high output CHF
- Rapid infusion of IV fluids, especially in premature infants
- Obstructive processes of the airway (enlarged tonsils or adenoids), cystic fibrosis (causes chronic hypoxemia that results in R-sided heart failure)
Clinical Features of CHF
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Pulmonary congestion:
- Tachypnea, cough, wheezing, rales (on exam)
- Pulmonary edema (on CXR)
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Impaired myocardial performance
- Tachycardia, sweating, pale or ashen skin color, diminished urine output
- Enlarged cardiac silhouette (on CXR)
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Systemic venous congestion
- Hepatomegaly
- Peripheral edema
- FTT, poor feeding (common symptom in newborns) / exercise intolerance (common symptom in older children)
- Cyanosis and shock = late manifestations
CHF mgmt
Goals:
- Improve myocardial fxn
- Relieve pulmonary/systemic congestion
Drugs:
- Cardiac glycosides (e.g., digoxin) - inc. efficiency of myocardial contractions and relieve tachycardia
- Loop diuretics (e.g., furosemide) - reduce intravascular volume by maximizing sodium loss –> diminished ventricular dilation and improved fxn
- Inotropic meds administered IV (e.g., dobutamine, dopamine)
- Phosphodiesterase inhibitors (e.g., milrinone) - improve contractility and reduce afterload
Interventional cath procedures: may address some of the underlying causes of CHF (e.g., balloon valvuloplasty for critical aortic and pulmonary valve stenosis)
Surgical repair: often definitive tx of CHF 2/2 CHD
What causes innocent murmurs?
What are the most common examples?
Turbulent blood flow NOT structural heart disease; have no hemodynamic significance
Clinical Features of Innocent Heart Murmurs
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Still’s murmur (ages 2-7)
- Grade II-III, mid-systolic vibratory murmur heard best near L lower sternal border/apex
- Source: Vibrations in ventricular or mitral structures caused by flow in L ventricle
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Pulmonic systolic murmur (any age)
- Systolic ejection murmur best heard at L upper sternal border
- Source: Turbulence of flow where the main pulmonary artery connects to the RV (across the pulmonary valve)
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Venous hum (any age)
- Continuous, soft humming murmur heard at neck or R upper chest that disappears in supine position
- Source: Turbulent flow in the jugular venous/SVC systems
Acyanotic Congenital Heart Disease: Types
ASD
VSD
PDA
Coarctation of the aorta (older child)
Aortic stenosis
Pulmonary stenosis
ASD
Classification, Clinical Findings, Mgmt
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Ostium primum
- Defect in lower portion of atrial septum
- A cleft, or division, in the anterior mitral valve leaflet may also be present and may cause MR** (watch out for CHF)
- Ostium primum ASD = common congenital heart lesion in Down Syndrome
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Ostium secundum
- Defect in middle portion of atrial septum
- Most common type of ASD
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Sinus venosus
- Defect high in septum near junction of RA and SVC
- R pulmonary veins usually drain anomalously into RA or SVC instead of into LA
Clinical findings:
- Increased RV impulse (as a result of RV overload)
- Systolic ejection murmur (from excessive pulmonary blood flow) best heard at mid and upper L sternal borders
- Fixed-split S2 (because of excessive pulmonary blood flow)
Mgmt:
- Closure by open heart surgery to prevent R-sided HF, pulmonary HTN, atrial dysrhythmias, paradoxical embolism
What is the pathologic concern of this condition?
PVR elevated in response to chronically high pulmonary flow
When PVR becomes elevated, the RV impulse is noticeably increased and the second heart sound may be single and loud. Mitral filling rumble disappears b/c of diminished pulmonary blood flow as a result of decreased L-R shunting. Symptoms of CHF also dec. as PVR inc. b/c of decrease in pulmonary blood flow.
What is the blood flow?
Through ductus from aorta to pulmonary artery (L to R shunt) –> inc. pulmonary blood flow
Eisenmenger syndrome
In extreme situation where PVR exceeds SVR, shunting changes from L-R to R-L
PDA
Physical Exam Findings
- “Machinery-like” continuous murmur at upper L sternal border
- If L-R shunt is large, diastolic rumble of blood flow across mitral valve at apex b/c of high flow rate
- Widened pulse pressure (>30 mm Hg) - shunting of blood will lower diastolic
- Brisk pulses
Neonates or infants with severe coarctation may depend on ____________ for perfusion of the lower thoracic and descending aorta.
R-L shunt through PDA
Initial mgmt in the symptomatic neonate for coarctation of the aorta
- IV prostaglandin E (to open ducutus arteriosus)
- Inotropic meds (to overcome myocardial depression)
- Low-dose dopamine to maximize renal perfusion and fxn
What is always present with a tricuspid atresia?
ASD or PFO
An atrial septal defect (ASD) and a ventricular septal defect (VSD) must both be present to maintain blood flow-from the right atrium, the blood must flow through the ASD to the left atrium to the left ventricle and through the VSD to the right ventricle to allow access to the lungs
What is the most common cause of acquired heart disease in children in the U.S.? Worldwide?
Kawasaki disease / ARF
Mgmt of Bacterial Endocarditis
IV antimicrobial therapy 4-6 weeks
Most common cause of pericarditis in children
Viral infection (coxsackievirus, echovirus, adenovirus, influenza, parainfluenza, EBV)