Ch. 7 Infectious Diseases Flashcards

1
Q

Typical Bacterial Pathogens and Empiric Abx for Infants and Children with Suspected Sepsis/Meningitis

0-1 mo

1-3 mo

3 mo-3 yrs

3 yrs-adult

A
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2
Q

Most common complication of meningitis

A

Hearing Loss (up to 25% pts)

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3
Q

Most common cause of viral meningitis in U.S.

A

Enterovirus

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4
Q

2 types of bacterial pharyngitis - what organisms?

A
  1. Group A Strep
    1. Lack of other URI symptoms (rhinorrhea, cough)
    2. Exudate on tonsils, petechiae on soft palate, strawberry tongue
    3. Fever
    4. Scarlatiniform rash
  2. Diphtheria
    1. Grey adherent tonsillar membrane
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5
Q

Most common pathogens for otitis externa?

A
  • Pseudomonas
  • S. aureus
  • Candida
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6
Q

Impetigo vs. Erysipelas vs. Cellulitis

A

Impetigo = superficial skin infection involving upper dermis

Erysipelas = skin infection that involves dermal lymphatics

  • Tender, erythematous skin with distinct border

Cellulitis = skin infection that involves dermal later

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7
Q

Complications of GABHS infections

A
  • PSGN
  • Rheumatic fever
  • Post-strep arthritis
  • Pediatric AI neuropsychiatric disorders associated with strep infection (PANDAS)
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8
Q

Classic electrolyte finding in bacterial diarrhea

A

Non-AG hyperchloremic metabolic acidosis (due to bicarb loss in stool)

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9
Q

Mgmt of infants born to HIV-infected mothers

A
  1. Zidovudine for 6 weeks for post exposure prophylaxis
  2. TMP/SX for Pneumocystis carinii pneumonia (PCP) prophylaxis until HIV DNA PCR at age 4 mo. is negative
  3. No breastfeeding
  4. Urine CMV culture to detect coinfection with CMV (ocurs in 5%)
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10
Q

EBV complications (5)

A
  1. Neurologic complications, including cranial nerve palsies/encephalitis
  2. Severe pharyngitis, which may cause upper airway obstruction
  3. Amoxicillin-associated rash. Pts with EBV infection who are misdiagnosed with GABHS pharyngitis and prescribed amox often develop diffiuse pruritic maculopapular rash 1 week after starting abx. Not an allergic rxn but is idiosyncratic
  4. Splenic rupture
  5. Malignancy (nasopharyngeal carcinoma, Burkitt’s lymphoma)
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11
Q

Most common complication of mumps

A

Aseptic meningitis

Orchitis in postpubertal males –> can impair fertility

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12
Q

Two common complications of acute otitis media

A

Facial nerve palsy / Mastoiditis

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13
Q

Common complication of rubella infection

A

Arthritis

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14
Q

Complication seen in primary measles / varicella

A

Pneumonia

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15
Q

Clinical phases of pertussis

A
  1. Catarrhal (1-2 weeks): Mild cough, rhinitis
  2. Paroyxsmal (2-6 weeks): Whooping cough, posttussive emesis, subconjunctival hemorrhages (from increased intraorbital pressure)
  3. Convalescent (weeks to months): sx gradually resolve
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16
Q

Treatment for localized non-bullous impetigo

A

Topical mupirocin

17
Q

Measles virus (rubeola)

Transmission

Clinical Presentation

Prevention

Treatment

A
  • Transmission: airborne
  • Clinical px:
    • Prodrome (e.g. cough, coryza, conjunctivitis, fever > 104, Koplik spots)
    • Maculopapular exanthem:
      • Cephaocaudal & centrifugal spread
      • Spares palms/soles
  • Prevention:
    • Live-attenuated measles vaccine
  • Tx:
    • Supportive
    • Vitamin A for hospitalized pts
18
Q

How does congenital toxoplasmosis classically present?

How is dx made?

A
  • Diffuse intracerebral calcifications
  • Ventriculomegaly / macrocephaly
  • Majority of infants are asymptomatic at birth but develop chorioretinitis in adulthood due to reactivation of their infection

Dx made by serology; presence of infant IgM or IgA is confirmatory

19
Q

Primary distinguishing feature between herpangina vs. herpetic gingivostomatitis

A

Herpangina = coxsackie A

  • 3-10 y/o
  • seasonal - summer/early fall
  • GRAY VISCLES/ULCERS ON POSTERIOR OROPHARYNX
  • Tx: supportive

Herpetic gingivostomatitis = HSV

  • 6 mo-5 yrs
  • seasonal - none
  • clusters of small vesicles on anterior oropharynx
  • Tx: oral acyclovir
20
Q

Classic triad of congenital rubella syndrome (CRS)

A
  • Machine-like systolic murmur of PDA
  • Sensorineural hearing loss
  • Leukocoria (white pupillary reflex) from cataracts
21
Q

Features specific for congenital syphilis

A
  1. Copious clear, purulent, or serosanguineous rhinorrhea (snuffles)
  2. Diffuse maculopapular rash that can involve the palms and soles and may desquamate
  3. Abnormal long-bone radiographs (eg. metaphyseal lucencies)
22
Q

Anterior vs. posterior cervical lymphadenopathy

A

Anterior: scarlet fever (S. pyogenes)

Posterior: EBV

23
Q

3 most commonly implicated organisms that cause acut bacterial rhinosinusitis

Treatment of choice

A
  • S. pneumo
  • H. influenzae
  • Moraxella catarrhalis

Treatment of choice: amox-clavulanic acid

24
Q

In an infant with meningococcemia, what out for __________.

A

Waterhouse-Friderichsen syndrome, which is characterized by a skin rash (i.e., large purpuric lesions on the flanks) due to adrenal hemorrhage