ch 7 Flashcards
1
Q
protein degradation pathways, half lives, g/day
A
ubiquitin-proteasome, chemical signals - min/hr(regulatory proteins) weeks/months/years (collagen) - 300/400 g/day
2
Q
proteolysis
A
The hydrolytic cleavage of proteins by proteases, occurs in the stomach and small intestines
3
Q
proteins absorbed at _______
proteins enter blood liver and peripheral tissues at _____
A
endothelial cells
portal vein
4
Q
protealytic enzymes secreted as
activated by
A
inactive zymogens(so they don't break down proteins in the cells where they are made and stored) proteolysis - allows for proper folding of enzyme
5
Q
trypsin
A
preferentially cleaves peptide bonds between hydrophobic amino acids and aromatic amino acids
6
Q
chymotrypsin
A
preferentially cleaves peptide bonds after an aromatic amino acid
7
Q
elastase
A
cuts after amino acids with smaller, hydrophobic side chains such as gly, ala
