Ch 47 Lipid Lowering Agents Flashcards
Antihyperlipidemic agent
General term used for drugs used to lower lipid levels in the blood
Bile acids
Cholesterol containing acids found in the bile that act like detergents to break up fats in the small intestine
Cholesterol
Necessary component of human cells that is produced and processed in the liver and then stored in the bile until stimulus causes the gallbladder to contract and send the bile into the duodenum via the common bile duct; a fat that is essential for the formation of steroid hormones and cell membranes; it is produced in cells and taken in by dietary sources
Chylomicron
Carrier for lipids in the bloodstream, consisting of proteins, lipids, cholesterol, and so forth
High density lipoprotein HDL
Loosely packed chylomicron containing fats, able to absorb fats and fat Remnants. in the arteries ; thought to have a protective effect, decreasing the development of coronary artery disease
Hydroxymethylglutaryl coenzyme A HMG-CoA reductase
 enzyme that regulates the last step in cellular cholesterol synthesis
Low density lipoprotein LDL
Tightly packed fats that are thought to contribute to the development of coronary artery disease when remnants left over from the LDL are processed in the arterial lining
Hyperlipidemia
Increased levels of lipids in the serum, associated with increased risk of coronary artery disease development
Metabolic syndrome
A collection of factors, including insulin resistance, abdominal obesity, low high density lipoprotein and high triglyceride levels, hypertension and pro-inflammatory and prothrombotic states that increase the incidence of coronary artery disease
Proprotein convertase subtilisin/kexin type 9
An enzyme that binds to LDL receptors on liver cells, which causes higher LDL levels in the blood
Risk factors
Factors that have been identified and as increasing the risk of the development of a disease; for coronary artery disease, risk factors include genetic predisposition, gender, age, high fat diet, Sedentary lifestyle, gout, hypertension, diabetes, and estrogen deficiency
Lipid lowering agents
Bile acid sequestrant
Cholestyramine
Colesevelam
Colestipol
Lipid lowering agents
HMG COA reductase inhibitors
Atorvastatin
Fluvastatin
Lovastatin
Pitavastatin
Pravastatin
Rousvastatin
Simvastatin
Lipid-lowering agents
Cholesterol absorption inhibitor
Ezetimibe
Lipid lowering agents
PCSK9 inhibitors
Alirocumab
Evolocumab
