Ch 35 Nonopioid Analgesics

Question 0

NSAIDS

Answer 0

Cox 1 and cox 2 inhibitors
Aspirin
Ibuprofen ( Motrin, Advil, IV preparations include caldolor, NeoProfen)
Naproxen (naprosyn) naproxen sodium ( aleve)
Indomethacin ( Indocin)
Diclofenac ( oral forms- voltaren, cataflam, zipsor; intradermal forms- Flector patch, Pennsaid, voltaren gel)
Ketoconazole ( generic, Sprix, an intranasal form)
Meloxicam ( mobic)

2nd generation;
Celecoxib ( Celebrex)

Question 1

What’s the overview of NONOPIOD drugs

Answer 1

NONOPIOD analgesics may have an anti inflammatory, antipyretic and analgesic action. These meds include non steroidal anti inflammatory drugs and acetaminophen

Question 2

What’s the expected pharmalogical action of NSAIDS

Answer 2

Inhibition of cyclooxygenase- inhibition of COX 1 can result in decreased platelet aggregation and kidney damage. Inhibition of cox 2 results in decreased inflammation, fever, and pain

Question 3

What are the therapeutic uses of NSAIDS

Answer 3

Inflammation supression
Analgesia for mild to moderate pain such as osteoarthritis and rheumatoid arthritis
Fever reduction
Dysmenorrhea
Inhibition of platelet aggregation which protects against ischemic stroke and MI