CH 35: Diagnostic Studies Flashcards
pages 786-794
A 62-year-old male presents to the emergency department with crushing substernal chest pain radiating to his left arm. The nurse anticipates the provider will order which laboratory test as the most specific indicator of myocardial infarction?
A. CK-MB
B. Troponin I
C. C-reactive protein
D. BNP
B. Troponin I
Rationale: Troponin I is the preferred test for detecting myocardial injury/ischemia due to its high sensitivity and specificity. Levels rise within 90 minutes and remain elevated for several days, aiding in early diagnosis and monitoring.
A patient with a history of heart failure presents with worsening shortness of breath and fatigue. Which lab value would the nurse expect to be elevated?
A. CK-MB
B. C-reactive protein
C. BNP
D. Troponin T
C. BNP
Rationale: BNP (b-type natriuretic peptide) is released in response to ventricular stretch and volume overload, making it a key biomarker in diagnosing and assessing the severity of heart failure.
A nurse is educating a patient about C-reactive protein (CRP). Which of the following statements are true regarding CRP? (SATA)
A. CRP is a marker of inflammation.
B. A CRP level >3 mg/dL indicates high cardiovascular risk.
C. CRP is the preferred test for diagnosing myocardial infarction.
D. Bacterial infections and inflammatory disorders can increase CRP levels.
E. CRP levels fluctuate rapidly and are unreliable.
A. CRP is a marker of inflammation.
B. A CRP level >3 mg/dL indicates high cardiovascular risk.
D. Bacterial infections and inflammatory disorders can increase CRP levels.
Rationale: CRP is a marker of inflammation and may predict cardiovascular risk. Levels >3 mg/dL indicate high risk. CRP increases in bacterial infections and inflammatory conditions but is not used to diagnose MI.
A 48-year-old male with hypertension and a BMI of 32 is undergoing a lipid panel. Which LDL level would place him at high risk for coronary artery disease?
A. 100 mg/dL
B. 125 mg/dL
C. 145 mg/dL
D. 170 mg/dL
D. 170 mg/dL
Rationale: LDL levels >160 mg/dL indicate a high risk for coronary artery disease. Management includes lifestyle changes and possibly statin therapy.
A nurse is reviewing lab results for a patient with suspected myocardial infarction. The CK-MB level is 3% of total CK. What is the nurse’s best interpretation of this finding?
A. This level confirms an MI.
B. This level is within normal limits.
C. CK-MB should be drawn 24 hours after symptom onset.
D. This result indicates heart failure.
B. This level is within normal limits.
Rationale: CK-MB levels <4–6% of total CK are not indicative of MI. CK-MB rises within 3–6 hours of an MI, peaks at 12–24 hours, and returns to normal within 48 hours.
A patient with a history of early-onset coronary artery disease is found to have an elevated homocysteine level. Which dietary recommendations should the nurse provide?
A. Increase vitamin B12 and folate intake.
B. Reduce sodium and fluid intake.
C. Consume a high-protein diet.
D. Increase simple carbohydrates.
A. Increase vitamin B12 and folate intake.
Rationale: Elevated homocysteine levels are linked to cardiovascular disease and are often associated with vitamin B12 and folate deficiencies.
Which factors can contribute to elevated triglyceride levels? (SATA)
A. Diabetes mellitus
B. Chronic kidney disease
C. Alcohol consumption
D. High HDL levels
E. High carbohydrate intake
A. Diabetes mellitus
B. Chronic kidney disease
C. Alcohol consumption
E. High carbohydrate intake
Rationale: Diabetes, kidney disease, alcohol intake, and a high-carb diet can raise triglycerides. High HDL levels are not associated with elevated triglycerides.
A 78-year-old patient has an NT-ProBNP level of 500 pg/mL. How should the nurse interpret this result?
A. This is normal for the patient’s age.
B. This level indicates severe heart failure.
C. This result suggests myocardial infarction.
D. The patient likely has an inflammatory disorder.
A. This is normal for the patient’s age.
Rationale: NT-ProBNP increases with age. For patients >75 years old, a level up to 449 pg/mL is considered normal.
A patient has an Lp(a) level of 40 mg/dL. How should the nurse interpret this finding?
A. The patient is at increased risk for atherosclerosis.
B. This level is normal.
C. The patient has a low risk for stroke.
D. The patient needs immediate anticoagulation therapy.
A. The patient is at increased risk for atherosclerosis.
Rationale: Lp(a) >30 mg/dL is associated with a higher risk of atherosclerosis, MI, and stroke.
A patient has a high-sensitivity Troponin T (hsTnT) level of 18 ng/L. How should the nurse interpret this result?
A. This is normal for a male patient.
B. This level indicates a severe MI.
C. The patient requires immediate thrombolytic therapy.
D. This is normal for a female patient.
A. This is normal for a male patient.
Rationale: Normal hsTnT levels are <22 ng/L in men and <14 ng/L in women.
A 55-year-old male with a history of hypertension and obesity has a routine lipid panel drawn. His total cholesterol level is 240 mg/dL. What is the priority intervention?
A. No intervention is needed since this value is only slightly elevated.
B. The patient should start a low-fat diet and increase physical activity.
C. The patient should take over-the-counter fish oil supplements.
D. The provider will likely prescribe a short-term course of statins.
B. The patient should start a low-fat diet and increase physical activity.
Rationale: A total cholesterol level >200 mg/dL increases the risk of coronary artery disease (CAD). First-line treatment includes dietary changes and exercise. Statin therapy is considered if lifestyle modifications do not lower cholesterol sufficiently.
Which HDL level is considered protective against cardiovascular disease?
A. 30 mg/dL
B. 45 mg/dL
C. 55 mg/dL
D. 65 mg/dL
D. 65 mg/dL
Rationale: HDL levels ≥60 mg/dL are considered protective against cardiovascular disease by helping remove excess cholesterol from the bloodstream.
A nurse is assessing a patient with dyspnea and suspected heart failure. Which conditions could cause an elevation in BNP levels? (SATA)
A. Chronic kidney disease
B. Myocardial infarction
C. Pulmonary hypertension
D. Dehydration
E. Atrial fibrillation
A. Chronic kidney disease
B. Myocardial infarction
C. Pulmonary hypertension
E. Atrial fibrillation
Rationale: BNP is released in response to ventricular stretch and fluid overload. It is elevated in heart failure, chronic kidney disease (due to impaired clearance), myocardial infarction (due to cardiac stress), pulmonary hypertension, and atrial fibrillation. Dehydration does not elevate BNP.
A 60-year-old woman with no history of heart disease undergoes routine blood work. Her high-sensitivity C-reactive protein (hs-CRP) level is 4 mg/dL. What does this finding indicate?
A. Low risk for cardiovascular disease
B. Moderate risk for cardiovascular disease
C. High risk for cardiovascular disease
D. This test is only relevant in patients with diagnosed CAD
C. High risk for cardiovascular disease
Rationale: An hs-CRP level >3 mg/dL indicates high cardiovascular risk. CRP is a marker of systemic inflammation and has been linked to an increased risk of myocardial infarction and stroke.
A patient scheduled for a fasting lipid panel asks how to prepare for the triglyceride test. Which instruction should the nurse provide?
A. “Avoid alcohol for 24 hours before the test.”
B. “You may eat a light meal before the test.”
C. “Take your usual medications, including lipid-lowering drugs.”
D. “You should exercise vigorously right before the test to get accurate results.”
A. “Avoid alcohol for 24 hours before the test.”
Rationale: Alcohol can significantly increase triglyceride levels and should be avoided for 24 hours before testing. Fasting for at least 8–12 hours is also recommended.
A 70-year-old male presents to the emergency department with intermittent chest pain that started 12 hours ago. His initial CK-MB and troponin levels are within normal limits. What is the most appropriate action?
A. Rule out myocardial infarction based on the normal lab values.
B. Obtain another set of cardiac biomarkers in 6–12 hours.
C. Prepare the patient for an immediate coronary angiography.
D. Check BNP levels to assess for heart failure.
B. Obtain another set of cardiac biomarkers in 6–12 hours.
Rationale: Troponin levels can take several hours to rise after myocardial injury. Serial testing is required to confirm or rule out an MI.
Which laboratory test is most specific for assessing vascular inflammation and increased risk for coronary artery disease?
A. C-reactive protein (CRP)
B. Lipoprotein-associated phospholipase A2 (Lp-PLA2)
C. BNP
D. CK-MB
B. Lipoprotein-associated phospholipase A2 (Lp-PLA2)
Rationale: Lp-PLA2 is an enzyme associated with vascular inflammation and is a specific marker for atherosclerosis and coronary artery disease (CAD). CRP is a general inflammation marker but is not as specific for CAD.
Which conditions can cause elevated troponin levels aside from myocardial infarction? (SATA)
A. Heart failure
B. Sepsis
C. Pulmonary embolism
D. Hypertension
E. Chronic kidney disease
A. Heart failure
B. Sepsis
C. Pulmonary embolism
E. Chronic kidney disease
Rationale: Troponin can be elevated in conditions that cause myocardial stress or injury, such as heart failure, sepsis, pulmonary embolism, and chronic kidney disease. Hypertension alone does not typically elevate troponin unless it leads to cardiac damage.
A 52-year-old female has an LDL cholesterol level of 170 mg/dL. She asks what she can do to lower her risk of heart disease. What is the most appropriate recommendation?
A. “Increase your intake of saturated fats to raise HDL levels.”
B. “Exercise regularly and reduce intake of processed foods.”
C. “Take a daily aspirin to lower cholesterol levels.”
D. “Increase simple carbohydrates to balance lipid metabolism.”
B. “Exercise regularly and reduce intake of processed foods.”
Rationale: Lifestyle modifications, including a diet low in saturated fats and regular exercise, are first-line treatments for high LDL cholesterol. Aspirin is used for its antiplatelet effects, not for lowering LDL.
A patient with chest pain has a copeptin level of 12 pmol/L. What does this finding suggest?
A. The patient has a high probability of myocardial infarction.
B. The patient’s copeptin level is normal and does not indicate MI.
C. The patient is experiencing acute heart failure.
D. The copeptin level suggests chronic kidney disease.
A. The patient has a high probability of myocardial infarction.
Rationale: Copeptin is a marker of arginine vasopressin release and increases rapidly in myocardial infarction. A level >10 pmol/L suggests a high likelihood of MI.
A 62-year-old male presents to the emergency department with chest pain that started 3 hours ago. His initial troponin level is within normal limits. What is the most appropriate next step?
A. Discharge the patient since the troponin level is normal.
B. Obtain a copeptin level to rule out myocardial infarction.
C. Repeat the troponin level in 3 hours.
D. Order an immediate cardiac stress test.
C. Repeat the troponin level in 3 hours.
Rationale: Troponin levels may take 4–6 hours to rise after myocardial injury. Serial measurements are needed to detect a trend in elevation.
Which laboratory findings are most indicative of acute coronary syndrome (ACS)? (SATA)
A. Elevated cardiac-specific troponin
B. Normal CK-MB levels
C. Increased copeptin
D. Decreased red blood cell count
E. Increased CK-MM levels
A. Elevated cardiac-specific troponin
C. Increased copeptin
Rationale: Elevated cardiac troponin and copeptin levels indicate myocardial injury. CK-MB may rise but is not as specific or reliable as troponin. RBC count is unrelated to ACS, and CK-MM is specific to skeletal muscle, not the heart.
How long after myocardial infarction can cardiac troponin levels remain elevated?
A. 2–4 days
B. 5–7 days
C. 10–14 days
D. 20–25 days
C. 10–14 days
Rationale: Troponin levels peak at 10–24 hours and can remain elevated for up to 10–14 days, making it useful for late diagnosis of MI.
A patient with suspected myocardial infarction has a normal troponin level at presentation. The provider orders a copeptin test, which is significantly elevated. What does this finding suggest?
A. The patient is at low risk for an acute cardiac event.
B. The patient likely has had a recent stroke.
C. The patient has a high probability of acute myocardial infarction.
D. The patient should be evaluated for heart failure instead of ACS.
C. The patient has a high probability of acute myocardial infarction.
Rationale: Copeptin is a substitute marker for arginine vasopressin and rises rapidly after MI. When combined with troponin, it increases the sensitivity for early MI detection.