Ch 3 Antigens

Question 1

Major histocompatability complex (MHC)

Answer 1

chromosome 6 short arm, humoral and cellular immunity, carriers of peptide antigens for
recognition by T cells

Question 2

Immunogen

Answer 2

cause adaptive

Question 3

Immunogenicity

Answer 3

macromolecular size (10-100), foreignness, chemical composition/molecular complexity, ability to be processed and presented within MHC molecules

Question 4

Primary/secondary/tertiary/quarternary

Answer 4

linear/alpha helices(spiral), beta pleated sheets(zigzag)/[folds of secondary structures/2 or more polypeptide chains(multimeric unit)] B cell detect

Question 5

peptides

Answer 5

small protein fragments that T cells detect (primary structure), MHC cradle for antigen recognition

Question 6

Polysachharide (glycolipid/glycoprotein)

Answer 6

less immunogenic (smaller), T cell not recognise carbs, A,B,H blood group antigens/Rh and Lewis antigen

Question 7

Epitope

Answer 7

antigenic determinant, precise molecular configurations B cell recognise on surface, peptide sequence/antigen presented to MHC molecules T cell

Question 8

Linear epitope

Answer 8

sequential amino acids on a single polypeptide chain (T cell detect after protein degrade and epitope out)

Question 9

Conformation epitope

Answer 9

folding of one or more polypeptide chains bring amino acids together to be recognized

Question 10

Haptens

Answer 10

nonimmunogenic until combined with laerger acrrier molecule

Question 11

Adjuvants

Answer 11

enhance immune response when delivered with antigen, stim toll like receptors, prevent diffusion

Question 12

Autoantigen

Answer 12

antigens belonging to host, no immune response

Question 13

Heteroantigen

Answer 13

antigens from other species

Question 14

Alloantigen

Answer 14

antigens from other host species

Question 15

Heterophile Antigens

Answer 15

Heteroantigens in unrelated plants/animals but identical structure in human, antibody react same

Question 16

Humoral immunity

Answer 16

B cell surface receptors bind to antigen directly

Question 17

Cell Mediated Immunity

Answer 17

T cell recognize antigens cradled within MHC

Question 18

Class I genes (MHC) T cell

Answer 18

loci A, B, C, all nucleated cells (lymphocytes and myeloid), process endogenous antigens and present to Tc

Question 19

Glycoprotein dimer (Class I)

Answer 19

2 noncovalently linked polypeptide chains (alpha chain with 3 domains, beta-2 microglobulin), one gene codes for each molecule (cell surface)

Question 20

Class II genes (MHC) Tcell

Answer 20

D region, loci DR, DQ, DP, one gene codes for alpha chain, more code for beta chain of molecule (2 domain each, on cell surface), on APCs, process exogenous antigens and present to Th (Th make B cell divide to plasma cell)

Question 21

Class III genes (MHC)

Answer 21

secreted proteins with immune function unlike I&II, codes for complement genes, C4a, C4b, C2, and B (and cytokines TNF),

Question 22

Anklosing Spondylitis

Answer 22

Class I B27, chronic inflammatory disorder of the spine vertebrae

Question 23

Celiac disease

Answer 23

Class II DQ2/8, diarrhea and weight loss

Question 24

Rheumatoid Arthritis

Answer 24

Class II DR4, multiple joint inflammation

Question 25

Type I Diabetes

Answer 25

Class II DQ2/8