Ch. 3 Anatomy, Physiology, and Pathology Flashcards

1
Q

Cytokine important in B and T cell development

A

IL-7

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2
Q

positive selection of T cells occurs?

A

thymic cortex

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3
Q

negative selection of T cells occurs?

A

begins in thymic cortex, finishes in medulla

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4
Q

What are Hassall corpuscles?

A

small bodies of granular cells surrounded by concentric layers of epithelial cells in the medulla

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5
Q

Where are resting B cells found?

A

primary follicle in the lymph node

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6
Q

Where is the germinal center of B cell proliferation located?

A

secondary follicle

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7
Q

Where are T cells located in the LN?

A

parafollicular cortex

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8
Q

How does the spleen receive lymphocytes and antigen?

A

via splenic artery (no afferent lymph supply)

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9
Q

Where is MALT (mucosa associated lymphoid tissue) located?

A

lamina propria and submucosa

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10
Q

Nasal airway resistance is regulated by?

A

swelling of the inferior turbinate at the level of the nasal valve

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11
Q

Which sinuses are present at birth?

A

maxillary and ethmoid sinuses

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12
Q

What sinuses drain into the middle meatus (into hiatus semilunaris)?

A

frontal, maxillary, and anterior ethmoids

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13
Q

What sinuses drain into the sphenoethmoidal recess?

A

posterior ethmoids, sphenoid sinus

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14
Q

What opens into the inferior meatus?

A

nasolacrimal duct

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15
Q

Where is the sphenoethmoidal recess located?

A

above the superior turbinate

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16
Q

Anterior ethmoid air cells above the middle turbinate

A

Agger nasi cells

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17
Q

Extramural ethmoid air cells found on the floor of the orbit

A

Haller cells

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18
Q

Sphenoethmoid air cell, found in close proximity to the internal carotid artery and optic nerve

A

Onodi cells

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19
Q

Air cell in the middle turbinate

A

Concha bullosa

20
Q

What innervates the tympanic membrane?

A

auriculotemporal nerve (perceives pain)

21
Q

3 most common causes of eustachian tube blockage in children?

A

infection, allergy, enlarged adenoids

22
Q

Corkscrew shaped twists of condensed mucus

A

Curschmann’s spirals

23
Q

Clusters of surface epithelial cells

A

Creola bodies

24
Q

Eosinophil cell and granule membrane lysophospholipase

A

Charcot Leyden crystals

25
Q

The epithelium, reticular basement membrane and bronchial smooth muscle remodeling differ in asthma compared to COPD in what ways?

A

Asthma: denuded epithelium, thickened BM, sm muscle hypertrophy in large airways rather than small airways

26
Q

Macrophages in the skin express what CD marker?

A

CD68

27
Q

Why epitope is expressed by dermal T cells that plays a role in skin homing?

A

CLA-1 (cutaneous lymphocyte antigen)

28
Q

Where are connective tissue MCtc mast cells located?

A

skin, conjunctiva (eye), heart, and intestinal submucosa

29
Q

Where are mucosal mast cells MCt located?

A

alveolar wall, respiratory epithelium and small intestinal mucosa

30
Q

Which mast cell type contains the CD88 receptor for C5a?

A

MCtc (connective tissue mast cell)

31
Q

What chemokines are important in skin homing?

A

CCR4 / CCL17 and CCR10 / CCL27

32
Q

Function of filaggrin?

A

matrix protein promoting aggregation and disulfide bonding of keratin filaments

33
Q

mutations in filaggrin have been associated with which diseases

A

atopic dermatitis and ichthyosis vulgaris

34
Q

in immunobullous disease what two biopsies are helpful for diagnosis

A

shave biopsy of intact bulla or vesicle; and biopsy of perilesional tissue for DIF

35
Q

Formation of erosion due to sheering pressure applied on normal appearing skin

A

Nikolsky’s sign

36
Q

Autoantibody for pemphigus vulgaris

A

IgG to desmoglein 1,3

37
Q

Autoantibody for bulls pemphigoid

A

IgG to BP230, BP180

38
Q

Autoantibody for dermatitis herpetiformis

A

IgA to epidermal transglutaminase

39
Q

Defensins are produced in response to what cytokines?

A

IL-1 and TNF

40
Q

Lymphoid follicles in GALT?

A

Peyer’s patches

41
Q

Specialized epithelial cells with microvilli that help in antigen sampling in the gut?

A

M cells

42
Q

which mediators are implicated in EoE

A

IL-5 and eotaxin

43
Q

Natural history of Allergic proctocolitis or eosinophilic proctolcolitis

A

presents in infancy with bloody stools, associated with breast fed, resolves that by age 1 year no association with atopy or IgE food allergy.

44
Q

Histopathology findings in celiac disease

A

blunted villi, crypt hyperplasia, and lymphocytic infiltrate

45
Q

Diagnosis of celiac disease

A

screen with IgA to TTG, and intestinal biopsy when patient still eating gluten