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ACAAI Review 3rd Edition > Ch 2. Cells Involved in Immune Response > Flashcards

Ch 2. Cells Involved in Immune Response Flashcards

1
Q

NKT cells have what type of TCR?

A

V alpha 24/J alpha 18, V beta 11

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2
Q

Tfh subtype are induced by what cytokine?

A

IL-21

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3
Q

IL-21 is important for?

A

Tfh differentiation, production of antibody in germinal centers

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4
Q

CD marker for IL-2Ra

A

CD25

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5
Q

Transcription factors for Th1 differentiation?

A

T-bet, STAT 4

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6
Q

Transcription factors for Th2 differentiation?

A

GATA-3, STAT 6

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7
Q

Transcription factors for Th17 differentiation?

A

RORyT, STAT 3

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8
Q

Transcription factors for Tfh differentiation?

A

Bcl-6 (upregulates CXCR5, down regulates CCR7)

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9
Q

Transcription factors for Treg differentiation?

A

FoxP3, STAT 5

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10
Q

Th1 differentiation induced by?

A

IL-12

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11
Q

Th2 differentiation induced by?

A

IL-4

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12
Q

Th17 differentiation induced by?

A

IL-17

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13
Q

Th9 differentiation induced by?

A

TGF-B

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14
Q

Treg differentiation induced by?

A

TGF-B

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15
Q

Th1 produce what major cytokine?

A

IFN-y

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16
Q

Th2 produce what major cytokine?

A

IL-4, -5, -13

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17
Q

Th17 produce what major cytokine?

A

IL-17

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18
Q

Th9 produce what major cytokine?

A

IL-9

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19
Q

Tfh produce what major cytokine?

A

IL-21

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20
Q

Treg produce what major cytokine?

A

IL-10, TGF-B

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21
Q

Difference between nTreg and iTreg

A

nTreg are thymus derived and express FoxP3, CD4, CD25. iTreg are peripheral derived, no FoxP3

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22
Q

cytokine for NK development

A

IL-15

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23
Q

cytokine needed for proliferation of T cell progenitors

A

IL-7

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24
Q

CD marker for common gamma chain

A

CD 132

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25
Q

CCR 7 binds?

A

CCL 19, 21 (high conc in T cell parafollicular zone)

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26
Q

CXCR 5 binds?

A

CXCL 13 (high conc in B cell follicle)

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27
Q

Pro-B cell surface markers

A

CD 43, 19, 20

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28
Q

Pre-B cell surface markers

A

CD 43, 19, 20; pre-BCR (u heavy chain and surrogate light chain)

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29
Q

Immature naive B cell markers

A

CD 19, 20, IgM

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30
Q

Mature naive B Cell markers

A

CD 19, 20, IgM, IgD

31
Q

double negative T cells in development express what markers?

A

CD3, preTCR (B-chain, pre-T alpha chain)

32
Q

Double positive T cells express?

A

CD3, CD4, CD8, TCRab

33
Q

Bim binds bax & bak and activates which caspase?

A

caspase 9

34
Q

FasL (CD178) and Fas (CD95) binds and activates which caspase?

A

caspase 8

35
Q

both caspase 8 and 9 converge on which caspase for apoptosis?

A

caspase 3

36
Q

monocytes and macrophages express what CD marker?

A

CD14, a component of TLR4 and LPS receptor (note: CD33 on macrophages)

37
Q

major cytokines secreted by macrophages

A

TNF-a, IL-1, IL-6, IL-12

38
Q

mutation in XLP?

A

SH2D1A gene mutation (encodes SAP)

39
Q

EBV infection in XLP can lead to?

A

HLH

40
Q

marker for Langerhans cells

A

CD11c, Birbeck granules, CD1a and CD207

41
Q

unlike other dendritic cells, pDCs express?

A

CD123 and NO CD11c!

42
Q

FcER1 is expressed primarily on what cells?

A

mast cells and basophils

43
Q

what is the function of PGE2

A

bronchodilation, suppress mast cells and eos, blocks 5-LO activation

44
Q

function of LTC4, LTD4, LTE4

A

increase vasc permeability, bronchoconstriction, mucus secretion

45
Q

location of MCt

A

respiratory, GI mucosa

46
Q

location of MCtc

A

respiratory/GI submucosa, skin, eye, synovium, blood vessels

47
Q

Which MC type has C5aR and responds to C5a, C3a, opiates and vancomycin and has a whorled appearance?

A

MCtc

48
Q

composition of high affinity IgE receptor on mast cells and basophils?

A

one alpha, one beta, two gamma chains

49
Q

How is the high affinity IgE receptor different on dendritic cells, monocytes, and eosinophils?

A

no beta chain (one alpha, two gamma chains)

50
Q

CD marker for low affinity IgE receptor?

A

CD23

51
Q

which allergen cleaves CD23 (low affinity IgE receptor?)

A

Der p 1

52
Q

What percent reduction is needed in specific IgE for clinical efficacy of Xolair?

A

96%

53
Q

What autoAb can be found in CIU?

A

IgG against alpha chain of high affinity receptor

54
Q

What chain of the high affinity IgE receptor binds IgE?

A

alpha chain

55
Q

Which cytokine is important for basophil expansion/differentiation

A

IL-3 (binds CD123 the IL-3 receptor)

56
Q

eosinophils migrate to tissue in response to?

A

RANTES (CCL5), eotaxin 1, -2 (CCL11, CCL24)

57
Q

Eosinophil levels are suppressed by?

A

fever, steroids

58
Q

primary cause of eosinophilia in U.S.? worldwide?

A

drugs; parasites

59
Q

mediators that attract neutrophils to tissue?

A

IL-8 (CXCL8), LTB4

60
Q

antibodies to what antigen in HIT?

A

PF4 (platelet antigen)

61
Q

antibodies to what antigen in ITP?

A

GPIIb/IIIa

62
Q

antibodies to what antigen in TTP?

A

ADAMTS13

63
Q

Wiskott-Aldrich syndrome

A

eczema, thrombocytopenia, infections

64
Q

target antigen and immunoflourescense for pemphigus vulgaris

A

desmoglein 3, intercellular IgG,IgM

65
Q

target antigen and immunoflourescense for bullous pemphigoid

A

BP230 (BPAg1), BP180 (BPAg2), linear IgG at BMZ

66
Q

target antigen for dermatitis herpetiformis

A

transglutaminase, granular IgA in dermis

67
Q

target antigen for linear IgA dermatosis

A

BP180 (BPAg2), linear IgA at BMZ

68
Q

what mediators released from epithelial cells are important in Th2 polarization?

A

TSLP, IL-33

69
Q

E-selectin and P-selection on endothelium bind to?

A

Sialyl-Lewis X on leukocytes

70
Q

L-selectin on leukocytes bind to?

A

Sialyl-Lewis X on GlyCAM-1/MadCAM-1 on HEV

71
Q

ICAM on endothelium bind to?

A

LFA-1 (CD11aCD18 integrin) on leukocytes

72
Q

VCAM on endothelium bind to?

A

VLA-4 integrin

73
Q

MadCAM-1 on gut endothelium bind to?

A

a4b7 integrin

ACAAI Review 3rd Edition (9 decks)

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