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Pharm 2 > Ch 29 > Flashcards

Ch 29 Flashcards

1
Q

__ appears to have an effect on muscle tone, thereby REDUCING muscle spasm

A

Cyclobenzaprine

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2
Q

__ contraindicated in clients with a recent MI, cardiac conduction disorders, and hyperthyroidism

A

Cyclobenzaprine

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3
Q

__ contraindicated during lactation and in clients with active hepatic disease

A

Oral dantrolene

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4
Q

CNS depressants (4) and effect of interaction with skeletal muscle relaxants

A

Alcohol, antihistamines, opiates, sedatives
Increased CNS depressant effect

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5
Q

These drugs have properties to produce immunosuppression, which in turn decreases the body’s autoimmune response. Therefore, in RA treatment, ___ are useful for their immunosuppressive ability

A

DMARDs

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6
Q

DMARDs are contraindicated in
SATA (5) & should not take methotrexate

A

Hypersensitivity
Renal insufficiency
Liver disease
Alcohol abuse
Pancytopenia
Folate deficiency

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7
Q

__ act primarily on the bone by inhibiting normal and abnormal bone resorption. This results in increased bone mineral density, reversing the progression of osteoporosis

A

Bisphosphonates

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8
Q

Interaction of bisphosphonate with ASA

A

Increased risk of GI bleeding

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9
Q

__ reduces the production of urine acid, thereby decreasing serum uric acid levels and the deposit of urate crystals in joints

A

Uric acid inhibitors

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10
Q

Adverse reactions of __ include severe N/V and bone marrow depression, therefore it is used as a SECOND line of treatment when other drugs fail

A

Colchicine

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11
Q

Colchicine is contraindicated in clients with serious (5)

A

GI, renal, hepatic, cardiac disorders
Blood dyscrasias

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12
Q

Anaphylactic reactions have been seen with ___ therefore __ & __ are used to PREMEDICATE clients

A

Pegloticase
Antihistamines & corticosteroids

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13
Q

When bisphosphonates are administered __ levels are monitored before, during, and after therapy

A

Serum calcium levels

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14
Q

It is important to be alert to reactions such as (4)

A

Skin rash
Fever
Cough
Easy bruising

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15
Q

Specific client complaints that may seem unrelated to drug therapy (3)

A

Visual changes
Tinnitus
Hearing loss

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16
Q

Particular attention is paid to this adverse reaction because __ may occur

A

Visual changes
Irreversible retinal damage

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17
Q

__ is potentially toxic. Therefore, monitor lab tests closely for adverse reactions such as __ & __

A

Methotrexate
Thrombocytopenia & leukopenia

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18
Q

(3) studies monitored with methotrexate every __

A

Hematology
Liver function
Renal function
1-3 months

19
Q

When taking uric acid inhibitors encourage __. Daily amount should be __ to excreted urates & prevent urate acid stone formation in GI tract

A

Liberal fluid intake
2L/day

20
Q

May need to administer iv fluids if oral intake is not __

A

3000L/day

21
Q

Take drug with how many oz of water

A

6-8

22
Q

Take drug and remain in what position

A

Upright for at least 30 min

23
Q

DMARDs, uric acid inhibitors, and skeletal muscle relaxants are taken with or __ to minimize gastric distress

A

Immediately after meals

24
Q

Bisphosphonates are taken with __ and cannot eat or drinks __ after taking and must be in __ position

A

6-8 oz plain water
30 mins
Upright position

25
Q

Client may not see a therapeutic response until __ of therapy

A

3-6 weeks

26
Q

When taking drugs to treat gout, notify provider when __ occurs

A

Skin rash

27
Q

Skeletal muscle relaxants (4) (1 trade)

A

Baclofen
Cyclobenzaprine
Methocarbamol (Robaxin)
Orphenadrine

28
Q

Baclofen uses

A

Spasticity caused by MS, spinal cord injuries (intrathecal administration for sever spasticity)
Typically orally

29
Q

Cyclobenzaprine dosage

A

10-60 mg/ orally in divided doses

30
Q

Route of administration for orphenadrine and frequency

A

IV or IM q12hr

31
Q

DMARDs (4) (2 trades)

A

Hydroxychloroquine (Plaquenil)
Leflunomide
Methotrexate
Sulfasalazine (Azulfidine)

32
Q

Uses for hydroxychloroquine (Plaquenil)

A

RA, antimalarial

33
Q

Uses for lefluomide and adverse reaction

A

RA
Alopecia

34
Q

Methodextrate uses and adverse reactions

A

RA
Stomatitis

35
Q

DMARDs biologics
SATA (5)

A

Abatacept
Adalimumab (Humira)
Anakinra (Kineret)
Etanercept (Enbrel)
Inflximab (Remicade)

36
Q

Adverse reaction of anakinra

A

Pancytopenia

37
Q

Dosage range for adalimumab (Humira)

A

40mg subcut EVERY OTHER WEEK

38
Q

Bisphosphonates (2) (2 trades)

A

Alendronate (Fosamax)
Risedronate (Actonel)

39
Q

Uses for colchicine

A

Relief of ACUTE attacks of gout,
PREVENTS of gout attacks

40
Q

Uses for allopurinol

A

Management of symptoms of gout

41
Q

Adverse reactions of colchicine

A

Bone marrow depression

42
Q

Uses for pegloticase

A

Management of symptoms of gout

43
Q

Adverse reactions of pegloticase

A

Disease flare up, infusion reaction

44
Q

Uric acid inhibitors (3) (1 trade)

A

Allopurinol (Zyloprim)
Colchicine
Pegloticase

Pharm 2 (7 decks)

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