ch. 27: hypertensive disorders Flashcards
What are the 3 common types of hypertensive disorders?
1) gestational htn
2) preeclampsia
3) chronic essential htn
When do gestational htn and preeclampsia develop?
after 20 weeks of gestation
What is PREECLAMPSIA?
-pregnancy-specific condition
-HTN & PROTEINURIA develops after 20 weeks of gestation in a previously normotensive woman
-can also develop for FIRST time during POSTPARTUM
What is PREECLAMPSIA defined as in the absence of PROTEINURIA?
HTN along w/
-thrombocytopenia
-impaired liver func
-new onset renal insufficiency
-pulmonary edema
-new-onset cerebral or visual disturbances
What is the ROOT CAUSE of PREECLAMPSIA?
-placenta
-only cure is delivery
What is the pathophysiology of PREECLAMPSIA?
-normally the arteries in the uterus become larger and thicker to handle increased BV
-this vascular remodeling DOES NOT OCCUR or only PARTIALLY DEVELOPS in women w/ preeclampsia
-results in: ↓ PLACENTAL PERFUSION & ENDOTHELIAL DYSFUNCTION
What does the generalized vasospasm in preeclampsia lead to?
-poor tissue perfusion
-↑ peripheral resistance and BP
-↑ endothelial cell permeability: LEAKING EVERYWHERE
What are common risk factors for PREECLAMPSIA?
-multifetal preg
-hx of preeclampsia
-chronic htn
-preexisting diabetes &/or thrombophilias
-women w/ limited sperm exposure w/ same partner
-paternal factors
What is HELLP syndrome?
-lab dx for a variant of preeclampsia that involves hepatic dysfunction characterized by:
1) HEMOLYSIS
2) ELEVATED LIVER ENZYMES
3) LOW PLATELET
Who can develop HELLP syndrome?
can develop in women who DONT have htn or proteinuria
What is HELLP syndrome a result of?
result of arterial vasospasm, endothelial cell dysfunction w/ fibrin deposits, & adherence of platelets in blood vessels
What are signs and symptoms of HELLP syndrome?
-hx of malaise
-flu like s/s
-epigastric or RUQ pain
-s/s WORSEN at night and IMPROVE during DAYTIME
Is there a reliable test or screening tool to ID preeclampsia?
no
What are elevated levels of PROTEINURIA?
+1 on dipstick OR > 300mg/day in a 24 hr collection
What do you assess for in preeclampsia?
-BP
-edema
-DTR
-proteinuria
What are signs of SEVERE preeclampsia?
-headache
-epigstric pain
-RUQ abd pain
-visual disturbances
What is the GOAL of interventions for GESTATIONAL HTN & PREECLAMPSIA W/O SEVERE FEATURES?
1) ensure maternal safety
2) deliver a healthy newborn as close to term as possible
Are there any benefits of activity restrictions for women w/ preeclampsia?
no