ch 27 Antilipemic Drugs

Question 1

The risk of coronary heart disease in patients with cholesterol levels of

Answer 1

of 300 mg/dL is three to four times greater than that in patients with levels less than 200 mg/dL

Question 2

antilipemic-Drugs used to lower lipid levels

Answer 2

Hydroxymethylglutaryl–coenzyme A (HMG–CoA) reductase
Bile acid sequestrants
B vitamin niacin (vitamin B3, nicotinic acid)
Fibric acid derivatives

Question 3

HMG-CoA Reductase Inhibitors (Statins)

Answer 3

Most potent LDL reducers
atorvastatin
First-line drug therapy for hypercholesterolemia
adverse effects
Myopathy (muscle pain), possibly leading to the serious condition rhabdomyolysis
-Diltiazem –ccb no grapefruit juice

Question 4

Rhabdomyloysis

Answer 4

Breakdown of muscle protein
Myoglobinuria: urinary elimination of the muscle protein myoglobin
Instruct patients to immediately report any signs of toxicity, including muscle soreness or changes in urine color.
Ck-skeletal breakdown

Question 5

Atorvastatin

Answer 5

Take at night –cholesterol releasing at night

Question 6

Simvastatin

Answer 6

Lower total and LDL cholesterol as well as triglycerides

Question 7

Bile Acid Sequestrants

Answer 7

cholestyramine (Questran)-powder 1hr before
Prevent resorption of bile acids from small intestine
reasons to take
Type II hyperlipoproteinemia
Relief of pruritus associated with partial biliary obstruction (cholestyramine)
can be taken with statins
adverse effects Constipation
Heartburn, nausea, belching, bloating
Drug interactions
-All drugs must be taken at least 1 hour before or 4 to 6 hours after the administration of bile acid sequestrants
High doses of a bile acid sequestrant decrease the absorption of fat-soluble vitamins (A, D, E, and K)

Question 8

Cholestyramine (Questran

Answer 8

Contraindications: known hypersensitivity or phenylketonuria
Pregnancy and lactation considerations
Treatment of loose bowel movements
Caution when administering dry powder