Ch. 24 Schizophrenia Flashcards

1
Q

Which type of antipsychotic medication is most likely to produce extrapyramidal effects?

A

First-generation antipsychotic drugs.
The conventional, or first-generation, antipsychotic drugs are potent antagonists of dopamine receptors D2, D3, and D4. This makes them effective in treating target symptoms but also produces many extrapyramidal side effects because of the blocking of the D2 receptors.

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2
Q

Encephalopathic syndrome has occurred in a few clients when haloperidol is taken with which medication?

A

Lithium carbonate (Lithium)

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3
Q

A nurse is working with a client that has been diagnosed with delusional thoughts. Which is an initial short-term outcome appropriate for this client?

A

engage in reality oriented conversation
Delusions are not reality oriented; thus an appropriate outcome would be that the client will engage in reality-oriented conversation rather than discussing delusional beliefs. Delusions are fixed, false beliefs.

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4
Q

A client is diagnosed with schizoaffective disorder (SAD). The nurse understands that in addition to psychosis, the client must also exhibit:

A

SAD is characterized by periods of intense symptom exacerbation alternating with quiescent periods, during which psychosocial functioning is adequate. This disorder is at times marked by psychosis; at other times, by mood disturbance. When psychosis and mood disturbance occur at the same time, a diagnosis of schizoaffective disorder is made.

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5
Q

Which increases the risk for neuroleptic malignant syndrome (NMS)?

A

Dehydration, poor nutrition, and concurrent medical illness all increase the risk for NMS.

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6
Q

A client is admitted with the diagnosis of possible schizophrenia and to rule out (R/O) organic pathology. Based on this information, what treatment will the nurse expect for this client?

A

The CT will reveal structural changes in the brain that might be responsible for symptoms of psychosis (e.g., abscess, tumor).

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7
Q

A client diagnosed with schizophrenia is having delusions that the client is being plotted against by the government. This would be documented as which type of delusion?

A

A persecutory delusion is a belief that one is being watched, ridiculed, harmed, or plotted against.

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8
Q

A client is admitted to the psychiatric hospital with a diagnosis of schizophrenia. During the physical examination, the client’s arm remains outstretched after the nurse obtains the pulse and blood pressure, and the nurse must reposition the arm. The nurse interprets this as what?

A

Waxy flexibility, the ability to assume and maintain awkward or uncomfortable positions for long periods, is characteristic of catatonic schizophrenia. Clients commonly remain in these awkward positions until someone repositions them.

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9
Q

The client with schizophrenia makes the following statement, “I just don’t know how to count. The sky turned to fire. I have a ball in my head.” What term does the nurse use to document this statement?

A

Associative looseness is demonstrated through fragmented or poorly related thoughts and ideas. The series of disconnected thoughts best exemplifies this concept.

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10
Q

Which drug classification is the primary medication treatment for schizophrenia?

A

Antipsychotic drugs are the primary medical treatment for clients diagnosed with schizophrenia and are also used in psychotic episodes of acute mania, psychotic depression, and drug-induced psychosis.

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11
Q

A client was admitted to the psychiatric intensive care unit with schizophrenia. Among the client’s signs and symptoms, the client was experiencing nihilistic delusions. The nurse understands that these delusions involve a belief about what?

A

An impending calamity such as death
Delusions are erroneous, fixed beliefs that cannot be changed by reasonable argument. Nihilistic delusions involve the belief that one is dead or a calamity is impending; when these delusions involve bodily illness, they take hypochondriacal concerns to the utmost extreme.

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12
Q

A client with schizophrenia is prescribed a second-generation antipsychotic. The client’s parent asks, “About how long will it take until we see any changes in the symptoms?” Which response by the nurse would be most appropriate?

A

Generally, it takes about 1 to 2 weeks for antipsychotic drugs to effect a change in symptoms. During the stabilization period, the selected drug should be given an adequate trial, generally 6 to 12 weeks, before considering a change in the drug prescription. If treatment effects are not seen, another antipsychotic agent may be tried.

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13
Q

A client diagnosed with schizophrenia has been prescribed Clozapine (Clozaril). Which of the following is a potentially fatal side effect of this medication?

A

Agranulocytosis is manifested by a failure of the bone marrow to produce adequate white blood cells. 1-2% of patients

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14
Q

A client on the unit suddenly cries out in fear. The nurse notices that the client’s head is twisted to one side, the client’s back is arched, and the client’s eyes have rolled back in the sockets. The client has recently begun drug therapy with haloperidol. Based on this assessment, which would be the first action of the nurse?

A

Give a PRN dose of benztropine IM

The client is having an acute dystonic reaction; the treatment is anticholinergic medication.

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15
Q

How will the nurse be able to recognize and assess signs and symptoms of a psychotic disorder?

A

Reassure patient that they are safe. Acknowledge what they are hearing/seeing even though
recognize social withdrawal
positives: hallucinations
negatives

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16
Q

How can the nurse maintain a focused psychiatric assessment of the patient with a psychotic disorder?

A

Therapeutic communication

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17
Q

What can set off schizophrenia?

A

Traumatic events, but there is not one single thing, could be many other factors.

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18
Q

The police handcuffed the patient and transported him to your local ED. What law allows the police to transport the patient to the hospital against his will?

A

L2K

Legal 2000

19
Q

What are parameters to be put in L2K?

A

Danger to themselves or others

20
Q

Is patient having positive symptoms?

A

Hallucinations, delusions, bizarre behavior, catatonia, formal thought disorder.

21
Q

The patient arrives at the ED at 1pm where you are working as an RN. The police bring the patient in and assist him to a stretcher.
What are the nurse’s next actions involving the police??

A

Do we know anything about their support? What led up to this scenario? Get further info from police

22
Q

Number 1 priority with all patients?

and other things to assess for

A
Safety
others are suicide assessment, MSE
assess immediate needs
get vital signs 
triage to r/o medical or substance induced psychosis through medical workup
one on one
insurance? advocate for the client
23
Q

Which phase of Schizophrenia is this? Think about 3-pronged approach: medications? Nursing Interventions? Community Support / Resources?

A

Phase 1: Acute: Hospitalization? Danger to self or others? Refusing to eat? Too disorganized to provide self care? Observations (MSE)? Test and Treatment workup?
Phase II: Stabilization: Wellness Recovery Action Plan (WRAP) to help facilitate recovery
Phase III: Maintenance: Wellness Recovery Action Plan (WRAP) to help facilitate recovery

24
Q

What Types of Drugs Does a Toxicology Screen Detect?

A

Many substances can be discovered through toxicology screens. Common classes of drugs that may be detected by toxicology screens include:
alcohol, including ethanol and methanol
amphetamines, such asAdderall
barbiturates
benzodiazepines
methadone
cocaine
opiates, including codeine, oxycodone, and heroin
phencyclidine (PCP)
tetrahydrocannabinol (THC)
Depending on the drug, it may show up in the blood or urine within a few hours or weeks after being ingested. Certain substances, such as alcohol, are eliminated from the body fairly quickly. Other drugs, however, can be detected for several weeks after being used. One example is THC, which is in marijuana.

25
Q

RPR: Why Rapid Plasma Reagin?

A

The rapid plasma reagin test is a type of rapid diagnostic test that looks for non-specific antibodies in the blood of the patient that may indicate an infection by syphilis or related non-venereal treponematoses. It is one of several nontreponemal tests for syphilis

26
Q

What is the probable DSM-5 diagnosis for this patient based on information presented thus far?

A

Think cognitive symptoms:
Schizophrenia? Or other psychotic disorder? Schizophreniform disorder
Schizoaffective disorder
Could it be psychosis? Substance induced? Trauma induced and r/t PTSD?

27
Q

prazosin

A

PTSD for flashbacks and nightmares and sleep disturbances

28
Q

What are my expected findings of PTSD? Think about hx and comorbidities:

A

Exposure to traumatic event or re-exposure to trauma

29
Q

First-generation LAI antipsychotics include:

A

haloperidol decanoate

fluphenazine decanoate

30
Q

Why is cogentin (benztropine) important?

A

Helps with EPS

31
Q

Other medications and additional history

A

Cogentin (benztropine) 1mg PO QHS
Seroquel (quetiapine) 200mg PO BID
Desyrel (trazadone) 100mg PO QHS

History of HTN, uncontrolled DM with high blood glucose levels, and elevated cholesterol, all untreated. Hx of PTSD.

32
Q

Previous psychiatric admission information

A
Medications prescribed previously?
Any suicide attempts?
Any substance abuse?
Any history of violence?
Any previous arrests?
33
Q

Schizophrenia - Theory Burst

A

1% of population has schizophrenia
Most common psychotic disorder
Often results in chronic illness
Increased risk of suicide
Increased risk factor with positive family history of schizophrenia
First break- adolescence or young adulthood
Neurotransmitter involved- Dopamine
MRI, CT changes- very large ventricles; atrophy of brain tissue

34
Q

A client with Schizophrenia has been started on medication therapy with Clozapine. The nurse should assess for?

A

White Blood Cell Count

looking for agranulocytosis

35
Q

The nurse notes that a client with Schizophrenia and receiving an antipsychotic medication is moving her mouth, protruding her tongues, and grimacing as she watches television. The nurse determine that the client is experiencing which med complication?

A

Know about EPS

Ans: Tardive dyskinesia

Remember that hypertensive crisis occurs with MAOI’s

36
Q

Olanzapine medication details

A

OLANZapine pamoateZyprexa Relprevv
Therapeutic class: Antipsychotics
Pharmacologic class: Thienobenzodiazepines
Available Forms
Injection: 10 mg
Injection (extended-release suspension): 210 mg/vial; 300 mg/vial; 405 mg/vial
Tablets: 2.5 mg; 5 mg; 7.5 mg; 10 mg; 15 mg; 20 mg
Tablets (ODTs): 5 mg; 10 mg; 15 mg; 20 mg

37
Q

Olanzapine for Schizophrenia is an antipsychotic

A

Treats Schizophrenia
Adults: Initially, 5 to 10 mg PO once daily with the goal to be at 10 mg daily within several days of starting therapy. Adjust dose in 5-mg increments at intervals of 1 week or more. Most patients respond to 10 to 15 mg daily. Safety of dosages greater than 20 mg daily hasn’t been established. Or, for maintenance dosing, 150 mg (extended-release) IM every 2 weeks, or 300 mg (extended-release) IM every 2 or 4 weeks, or 210 mg (extended-release) IM every 2 weeks, or 405 mg (extended-release) IM every 4 weeks.
Children age 13 and older: 2.5 or 5 mg PO once daily. Adjust dose as needed in increments of 2.5 or 5 mg. Maintenance dose is 10 mg/day.

38
Q

Olanzapine adverse reactions/side effects

A

Adverse Reactions
CNS: somnolence, insomnia, parkinsonism, dizziness, NMS, suicide attempt, abnormal gait, asthenia, personality disorder, auditory hallucinations, restlessness, fatigue, akathisia, headache, tremor, articulation impairment, tardive dyskinesia, fever, extrapyramidal events (IM) such as muscle spasms and tremors, hypertonia.
CV: prolonged QT interval, orthostatic hypotension, tachycardia, chest pain, HTN, ecchymosis, peripheral edema, hypotension (IM).
EENT: amblyopia, conjunctivitis, rhinitis, pharyngitis.
GI: constipation, dry mouth, dyspepsia, increased appetite, increased salivation, vomiting, thirst.
GU: hematuria, metrorrhagia, urinary incontinence, UTI, amenorrhea, vaginitis, vaginal discharge.
Hematologic: leukopenia.
Metabolic: hyperglycemia, dyslipidemia, weight gain.
Musculoskeletal: joint pain, extremity pain, back pain, neck rigidity, twitching, muscle spasm, stiffness.
Respiratory: increased cough, dyspnea, URI.
Skin: sweating, ecchymosis, injection-site reaction, injection-site pain (IM).
Other: flulike syndrome, viral infection, injury.

Drug-herb
Kava kava: May increase adverse/toxic effect of olanzapine. Monitor patient.
St. John’s wort: May decrease drug level. Discourage use together.
Drug-lifestyle
Alcohol use: May increase CNS effects. Don’t use together.
Smoking: May increase drug clearance. Urge patient to quit smoking.

39
Q
venlafaxine hydrochloride
ven-la-FAX-een
Effexor XR
Therapeutic class: Antidepressants
Pharmacologic class: SSNRIs
A

Available Forms
Capsules (extended-release) : 37.5 mg; 75 mg; 150 mg
Tablets: 25 mg; 37.5 mg; 50 mg; 75 mg; 100 mg
Tablets (extended-release) : 37.5 mg; 75 mg; 150 mg; 225 mg

40
Q

venlafaxine hydrochloride - Major depressive disorder

A

Major depressive disorder
Adults: Initially, 75 mg (immediate-release) PO daily in two or three divided doses with food. Increase as tolerated and needed by 75 mg daily every 4 days. For outpatients who are moderately depressed, usual maximum is 225 mg daily; in certain patients who are severely depressed, dose may be as high as 375 mg daily. For extended-release capsules or tablets, 75 mg PO daily in a single dose. For some patients, it may be desirable to start at 37.5 mg PO daily for 4 to 7 days before increasing to 75 mg daily. Dosage may be increased by 75 mg daily every 4 days to maximum of 225 mg daily.
May switch immediate-release formulation to extended-release formulation by using the nearest equivalent dose in mg/day. For example, may switch 37.5 mg immediate-release b.i.d. to 75 mg extended-release daily.

41
Q

Nursing Care Plans for
Medical Diagnoses - Schizophrenia
Goals

A

Goals
Altered Health-Seeking Behavior
The patient will modify actions that are detrimental to health.
The patient will identify available support systems.

Altered Social Interaction
Goals
The patient will demonstrate positive changes in social interactions.

Anxiety
Goals
The patient will verbalize anxiety, concerns, and fears.
The patient will respond to relaxation techniques with decreased anxiety.

Coping Impairment
Goals
The patient will identify appropriate coping behaviors.
The patient will develop appropriate coping behaviors.
The patient will use appropriate coping behaviors.

Knowledge Deficiency
Goals
The patient will demonstrate knowledge retention related to schizophrenia.
The patient will demonstrate behaviors congruent with expressed knowledge.

Risky Health Behavior
Goals
The patient will identify positive, healthful behaviors.
The patient will exhibit healthful behaviors.

Social Isolation
Goals
The patient will increase social interactions.

Suicide Attempt Risk
Goals
The patient will refrain from self-inflicted injury in the health care setting.
The patient will state a desire to live.

Violence Risk
Goals
The patient will demonstrate self-control, as evidenced by a relaxed posture and non-violent behavior.

42
Q

Signs and Symptoms - Schizophrenia
Psychotic behavior
Overview

A

Inability or unwillingness to recognize and acknowledge reality and to relate with others
Possibly beginning suddenly or insidiously, progressing from vague complaints of fatigue, insomnia, or headache to withdrawal, social isolation, and preoccupation with certain issues, resulting in gross impairment in functioning
Possibly various behaviors occurring together or separately, including delusions, illusions, hallucinations, bizarre language, and perseveration
Delusions—persistent beliefs that have no basis in reality or in the patient’s knowledge or experience, such as delusions of grandeur
Illusions—misinterpretations of external sensory stimuli, such as an oasis in the desert, unlike hallucinations, which are sensory perceptions that don’t result from external stimuli
Perseveration—persistent verbal or motor response that may indicate organic brain disease with motor changes (including inactivity, excessive activity, and repetitive movements)
Bizarre language that reflects a communication disruption; can range from echolalia (purposeless repetition of a word or phrase) and clang association (repetition of words or phrases that sound similar) to neologisms (creation and use of words whose meaning only the patient knows)

43
Q

What is the purpose of the AIMS test?

A

To screen for movement disorders caused by antipsychotic medications. Stands for Abnormal Movement Medication Scale.