CH 22: Meds for Depressive Disorders

Question 1

Tricyclic antidepressants (TCA)

Answer 1

amitriptyline
imipramine
nortiptyline
trimipramine
- block reuptake of norepinepherine and serotonin
- 10-14 days to work, max effects in 4-8 weeks

Question 2

Complications of TCA

amitriptyline, imipramine, nortriptyline, trimipramine

Answer 2

orthostatic hypotension
antichoinergic effects
sedation
toxicity
decreased seizure threshold
diaphoresis
increased appetite

Question 3

contraindications of TCA

amitriptyline, nortrityline, imipramine, trimipramine

Answer 3

• category C
• seizure disorder
• caution with CAD, DM, liver/kidney/respiratory issues, urinary retention
• can increase suicide risk

Question 4

Selective serotonin reuptake inhibitor (SSRI)

Answer 4

fluoxetine
paroxetine
sertraline
citalopram
escitalopram
-block reuptake of serotonin

Question 5

Complications of SSRI

fuloxetine, paroxetine, sertraline, citalopram, excitalopram

Answer 5

sexual dysfunction
CNS stimulation (insomnia, agitation, anxiety)
weight changes
serotonin syndrome
withdrawal syndrome
hyponatrmia
rash
GI bleeding
bruxism
sleepiness, faintness, lightheadedness

Question 6

Contraindications of SSRI

fluoxetine, paroxetine, sertraline, citalopram, escitalopram

Answer 6

• category C
• oxetine’s increase birth defects
• MOAIs or TCAs
• caution with liver and/or renal dysfunction, cardiac disease, seizure, DM, ulcer, hx of GI bleeding