Ch 18 -Blood Flashcards
Albumins
Smallest
Maintain blood pressure and volume
Globulins
Antibodies
Fibrinogen
Involved in blood clotting
Regulatory proteins
Hormones
Erythrocyte
Transportation of respiratory gases
Lymphocyte
Differentiate into cells that produce antibodies
Neutrophil
Increase in number during bacterial infections
Basophil
Vasodilatory and anticoagulant more function
Eosinophil
Increase in number during parasitic infections
Ex. Worm or allergies
Monocyte
Involved with immune clearance
Granulocytes
Specific granules in their cytosol that are clearly visible when viewed with a microscope
Medical terms refer to synthesis of formed element
Hematopoiesis
Hemopoiesis
Steps of hemostasis
Vascular spasm
Platelet plug formation
Coagulation phase
Chemotaxis
Leukocytes attracted to molecules produced by damaged or dying cells
Leukopoiesis
Leukocyte production
Macrophages
Remove old/damaged erythrocytes
alpha globulins
Small
Transport lipids and hormones
Beta globulins
Large
Transport lipids and hormones
Gamma globulins
Aka antibodies
Produce immune cells and bind to antigens of pathogens
Hemoglobin
In cytosol of erythrocytes
Is a pigment
Is a protein
Transports oxygen and carbon dioxide
Hemocytoblast
All formed elements
Myeloid stem cell
Erythrocytes, Granulocytes, platelets, monocytes
Lymphoid stem cell
Leukocytes of immune response
Agranulocytes
Leukocytes with small specific granules in cytosol not clearly visible under microscope
Lymphocytes
Attack abnormal body cells
Coordinate immune responses
Leukocytes main classes (2)
Granulocytes
Agranulocytes
Sickle cell disease
Autosomal recessive mutation
Altered shape in hemoglobin
RBCs become clumped and stuck to blood vessels causing pain
Congenital hemolytic anemia
Often genetically determined
Malformation of erythrocyte membrane proteins
RBCs destroyed too rapidly!!
Erythroblastic anemia
Higher circulating number of immature, uncleared erythroblasts
Thrombopoesis
Platelet production
Erythropoietin
Stimulates development of erythrocytes
Produced by kidneys
Hormone
B lymphocyte
Become plasma cells and produce antibodies
T lymphocyte
Manage and direct immune responses
Attack infected body and foreign cells
Natural killer cell
Attack abnormal and infected body cells
Leukopenia
Reduced number of leukocytes
Agglutination
Binding of antibodies in the blood plasma to their corresponding surface antigens on Erythrocyte plasma membrane
Hemolysis
Rupture of erythrocytes
Hypoxemia
Low blood O2
Negative feedback
Erythropoietin (EPO)
Stimulates erythropoiesis in red bone marrow
RBC count rises 3-4 days
Stimuli:
Exercise
Smoking
Primary polycythemia
Excess RBCs
Cancer forming in bone marrow
Increased BP
Increased bleeding
Secondary polycythemia
Low blood O2
Thick blood
Heart failure
Hemorrhagic anemia
Loss of RBCs due to chronic bleeding
Thrombocytopenia
Low platelet count
Thrombocytosis
High platelet count
Cytokines
Inflammatory chemicals
Makes cells “do” things
Thrombus
Blood clot
Often in leg veins of women and inactive people
Embolus
Clot that breaks free
Travels to vital organ