Ch. 17 Bipolar Disorders Flashcards
Mania is…
An alteration in mood that may be expressed by feelings of elation, inflated self-esteem, grandiosity, hyperactivity, agitation, racing thoughts, and accelerated speech. Mania can occur as part of the psychiatric disorder bipolar disorder, as part of some other medical conditions, or in response to some substances.
Bipolar disorder is…
Age of onset
Characterized by mood swings from profound depression to extreme euphoria (mania) with intervening periods of normalcy.
Delusions or hallucinations may or may not be a part of the clinical picture, and onset of symptoms may reflect a seasonal pattern.
The diagnostic picture for depression associated with bipolar disorder is similar to that described for major depressive disorder, with one major distinction: the client must have a history of one or more manic episodes.
Average age at onset is 25 years.
Manic episode vs. hypomania
- During a manic episode, the mood is elevated, expansive, or irritable. The disturbance is sufficiently severe to cause marked impairment in occupational functioning or in usual social activities or relationships with others or to require hospitalization to prevent harm to self or others. Motor activity is excessive and frenzied. Psychotic features may be present.
- Hypomania is not severe enough to cause marked impairment in social or occupational functioning or to require hospitalization, and it does not include psychotic features.
Diagnostic Criteria for a Manic Episode
- A) A distinct period of abnormally and persistently elevated, expansive, or irritable mood and abnormally and persistently increased goal-directed activity or energy, lasting at least 1 week and present most of the day, nearly every day (or of any duration if hospitalization is necessary).
- B) During the period of mood disturbance and increased energy or activity, three (or more) of the following symptoms (four if the mood is only irritable) are present to a significant degree and represent a noticeable change from usual behavior:
1. Inflated self-esteem or grandiosity
2. Decreased need for sleep (e.g., feels rested after only 3 hours of sleep)
3. More talkative than usual or pressure to keep talking
4. Flight of ideas or subjective experience that thoughts are racing
5. Distractibility (i.e., attention too easily drawn to unimportant or irrelevant external stimuli), as reported or observed
6. Increase in goal-directed activity (either socially, at work or school, or sexually) or psychomotor agitation (i.e., purposeless non-goal-directed activity)
7. Excessive involvement in activities that have a high potential for painful consequences (e.g., engaging in unrestrained buying sprees, sexual indiscretions, or foolish business investments) - C. The mood disturbance is sufficiently severe to cause marked impairment in social or occupational functioning or to necessitate hospitalization to prevent harm to self or others, or there are psychotic features.
- D. The episode is not attributable to the physiological effects of a substance (e.g., a drug of abuse, a medication, or other treatment) or to another medical condition.
Diagnostic Criteria for a Hypomanic Episode
- A. A distinct period of abnormally and persistently elevated, expansive, or irritable mood and abnormally and persistently increased activity or energy, lasting at least 4 consecutive days and present most of the day, nearly every day.
- B. During the period of mood disturbance and increased energy and activity, three (or more) of the following symptoms (four if the mood is only irritable) have persisted, represent a noticeable change from usual behavior, and have been present to a significant degree:
1. Inflated self-esteem or grandiosity
2. Decreased need for sleep (e.g., feels rested after only 3 hours of sleep)
3. More talkative than usual or pressure to keep talking
4. Flight of ideas or subjective experience that thoughts are racing
5. Distractibility (i.e., attention too easily drawn to unimportant or irrelevant external stimuli), as reported or observed
6. Increase in goal-directed activity (either socially, at work or school, or sexually) or psychomotor agitation
7. Excessive involvement in pleasurable activities that have a high potential for painful consequences (e.g., engaging in unrestrained buying sprees, sexual indiscretions, or foolish business investments) - C. The episode is associated with an unequivocal change in functioning that is uncharacteristic of the individual when not symptomatic.
- D. The disturbance in mood and the change in functioning are observable by others.
- E. The episode is not severe enough to cause marked impairment in social or occupational functioning or to necessitate hospitalization. If there are psychotic features, the episode is, by definition, manic.
- F. The episode is not attributable to the physiological effects of a substance (e.g., a drug of abuse, a medication, or other treatment).
Bipolar I Disorder is…
- Diagnosis given to an individual who is experiencing a manic episode or has a history of one or more manic episodes.
- May also have experienced episodes of depression.
- Further specified by the current or most recent behavioral episode experienced: single manic episode (to describe individuals having a first episode of mania) or current (most recent) episode manic, hypomanic, mixed, or depressed (to describe individuals who have had recurrent mood episodes)
- Psychotic or catatonic features may also be noted.
- Length of manic episodes (and depressive episodes) is variable when an individual has more than four manic and depressive episodes in a year, he or she is referred to as having rapid cycling bipolar disorder.
Bipolar II Disorder is…
- Characterized by recurrent bouts of major depression with episodic occurrence of hypomania.
- May present with symptoms (or history) of depression or hypomania.
- Client has never experienced a full manic episode, and the symptoms are “not severe enough to cause marked impairment in social or occupational functioning or to necessitate hospitalization”
- Diagnosis may specify whether the current or most recent episode is hypomanic, depressed, or with mixed features
- If the current syndrome is a major depressive episode, psychotic or catatonic features may be noted.
Cyclothymic disorder is…
- Essential feature is a chronic mood disturbance of at least 2 years’ duration
- Involves numerous periods of elevated mood that do not meet the criteria for a hypomanic episode
- Numerous periods of depressed mood of insufficient severity or duration to meet the criteria for major depressive episode.
Diagnostic criteria for Cyclothymic disorder
- A. For at least 2 years there have been numerous periods with hypomanic symptoms that do not meet criteria for hypomanic episode and numerous periods with depressive symptoms that do not meet the criteria for a major depressive episode
- B. During the 2-year period, the hypomanic and depressive periods have been present for at least half the time, and the individual has not been without the symptoms for more than 2 months at a time.
- C. Criteria for a major depressive, manic, or hypomanic episode have never been met.
- D. The symptoms in Criterion A are not better explained by schizoaffective disorder, schizophrenia, schizophreniform disorder, delusional disorder, or other specified or unspecified schizophrenia spectrum and other psychotic disorder.
- E. The symptoms are not attributable to the physiological effects of a substance (e.g., a drug of abuse, a medication) or another medical condition (e.g., hyperthyroidism).
- F. The symptoms cause clinically significant distress or impairment in social, occupational, or other important areas of functioning.
Specify if: - With anxious distress
Substance/Medication-Induced Bipolar Disorder is…
- The disturbance of mood associated with this disorder is considered to be the direct result of physiological effects of a substance
- The mood disturbance may involve elevated, expansive, or irritable mood with inflated self-esteem, decreased need for sleep, and distractibility.
- The disorder causes clinically significant distress or impairment in social, occupational, or other important areas of functioning.
- Mood disturbances are associated with intoxication from substances such as alcohol, amphetamines, cocaine, hallucinogens, inhalants, opioids, phencyclidine, sedatives, hypnotics, and anxiolytics.
- Symptoms can also occur during withdrawal from substances such as alcohol, amphetamines, cocaine, sedatives, hypnotics, and anxiolytics.
- Anesthetics, analgesics, anticholinergics, anticonvulsants, antihypertensives, antiparkinsonian agents, antiulcer agents, cardiac medications, oral contraceptives, psychotropic medications, muscle relaxants, steroids, and sulfonamides
Bipolar Disorder Due to Another Medical Condition is…
- Characterized by an abnormally and persistently elevated, expansive, or irritable mood and excessive activity or energy that is judged to be the result of direct physiological consequence of another medical condition
- The mood disturbance causes clinically significant distress or impairment in social, occupational, or other important areas of functioning.
Biological Theories of Bipolar Disorders
Genetics
Research suggests that bipolar disorder strongly reflects an underlying genetic vulnerability. Evidence from family, twin, and adoption studies exists to support this observation.
- Twins: Concordance rate for bipolar disorder among monozygotic twins at 60 to 80 percent
- In general, family studies have shown that if one parent has a mood disorder, the risk that a child will have a mood disorder is between 10 and 25 percent
- “A family history of bipolar disorder conveys a greater risk for mood disorders in general and, specifically, a much greater risk for bipolar disorder”
Biochemical Influences of Bipolar Disorders
- Early studies have associated symptoms of mania with a functional excess of norepinephrine and dopamine.
- The neurotransmitter serotonin is believed to remain low in both depression and mania.
- Excess levels of acetylcholine
- Excessive levels of glutamate, an excitatory neurotransmitter have been associated with bipolar disorder. Many of the mood stabilizers used to treat bipolar disorder inhibit the actions of glutamate.
Neuroanatomical Factors of Bipolar Disorders
Neuroanatomical changes have been correlated with dysfunction in the prefrontal cortex, basal ganglia, temporal and frontal lobes of the forebrain, and parts of the limbic system, including the amygdala, thalamus, and striatum.
Medication Side Effects that affect Bipolar Disorder
- Steroids frequently used to treat chronic illnesses such as multiple sclerosis and systemic lupus erythematosus (SLE)
- Amphetamines, antidepressants, and high doses of anticonvulsants and narcotics also have the potential for initiating a manic episode.
Psychosocial Theories of Bipolar Disorders
- Conditions such as bipolar disorder are more often viewed as diseases of the brain with biological etiologies.
- However, studies have confirmed a link between childhood trauma (emotional, physical, and sexual abuse) and the development of bipolar disorder
- Childhood trauma interacts with genes along several pathways, which influences not only an increased risk for bipolar disorder but also earlier onset, more severe symptoms, substance abuse, and suicide risk.
Developmental Implications of Bipolar Disorders
- The lifetime prevalence of adolescent bipolar disorders is estimated to be about 1 percent and in younger children the incidence is very rare, but children and adolescents are often difficult to diagnose
- Thought to be a connection between ADHD and the development of bipolar disorder in youth
- Studies also found that youth who were given BP I diagnosis more often manifested with a host of atypical symptoms, including nondiscrete mood episodes, chronic irritability, and temper tantrums.
- Disruptive mood dysregulation disorder more aptly describes the symptom profile.
- When true mania associated with bipolar disorder does occur in adolescents, it is frequently accompanied by flight of ideas, grandiose or persecutory delusions, and hallucinations.
Treatment Strategies of Bipolar Disorders in Children
Psychopharmacology
- Monotherapy with the traditional mood stabilizers (e.g., lithium, divalproex, carbamazepine) or atypical antipsychotics (e.g., olanzapine, quetiapine, risperidone, aripiprazole) = first line treatment
- ADHD has been identified as the most common comorbid condition in children and adolescents with bipolar disorder. Because stimulants can exacerbate mania, it is suggested that medication for ADHD be initiated only after bipolar symptoms have been controlled with a mood-stabilizing agent
- Nonstimulant medications indicated for ADHD (e.g., atomoxetine, bupropion, the tricyclic antidepressants) may also induce switches to mania or hypomania.
Family Interventions for Bipolar Disorders
- Interventions with family members must include education that promotes understanding that at least part of the client’s negative behaviors are attributable to an illness that must be managed.
- Family-focused treatment (FFT) is an evidence-based intervention for reducing relapses and increasing medication adherence in bipolar clients
- FFT includes sessions that deal with psychoeducation about bipolar disorder (i.e., symptoms, early recognition, etiology, treatment, self-management), communication training, and problem-solving skills training.
- Teaching the client and family about early warning signs and management strategies provides the client with a needed support system and the family with tools and resources to provide that support.
Hypomania
Mood:
Cognition and Perception:
Activity and Behavior:
Mood:
- Cheerful and expansive.
- Underlying irritability that surfaces rapidly when the person’s wishes and desires go unfulfilled.
- The nature of the hypomanic person is volatile and fluctuating.
Cognition and Perception:
- Perceptions of the self are exalted.
- The individual has ideas of great worth and ability.
- Thinking is flighty with a rapid flow of ideas.
- Perception of the environment is heightened, but the individual is so easily distracted by irrelevant stimuli that goal-directed activities are difficult.
Activity and Behavior:
- Increased motor activity.
- Perceived as being very extroverted and sociable, but lack the depth of personality and warmth to formulate close friendships.
- Talk and laugh a great deal, usually very loudly and often inappropriately.
- Increased libido is common.
- Some individuals experience anorexia and weight loss.
- Inappropriate behaviors like calling the President or buying huge amounts of merchandise.
Acute mania “manic episode”
Mood:
Cognition and Perception:
Activity and Behavior:
Mood:
- Euphoria and elation.
- Continuous “high”
- Subject to frequent variation, easily changing to irritability and anger or even to sadness and crying.
Cognition and Perception:
- Fragmented and often psychotic
- Accelerated thinking proceeds to racing thoughts
- Overconnection of ideas
- Rapid, abrupt movement from one thought to another (flight of ideas)
- Continuous flow of accelerated, pressured speech (loquaciousness) to the point where trying to converse with them is difficult.
- When flight of ideas is severe, speech may be disorganized and incoherent.
- Distractibility becomes all-pervasive.
- Attention can be diverted by even the smallest of stimuli.
- Hallucinations and delusions (usually paranoid and grandiose) are common.
Activity and Behavior
- Psychomotor activity is excessive.
- Sexual interest is increased
- Poor impulse control
- Low frustration tolerance
- The individual who is normally discreet may become socially and sexually uninhibited.
- Little insight with regard to their behavior and communication
- Unreliable reporting of events and denial of problems when confronted by friends or family, both of which may be interpreted as lying.
- Energy seems inexhaustible, and the need for sleep is diminished. (days without sleep)
- Hygiene and grooming may be neglected.
- Dress may be disorganized, flamboyant, or bizarre, and the use of excessive makeup or jewelry is common.
Delirious Mania is…
A grave form of the disorder characterized by severe clouding of consciousness and an intensification of the symptoms associated with acute mania “manic episode”. This condition has become relatively rare since the availability of antipsychotic medication.