Ch 15 Specific, acquired, adaptive immunity Flashcards

You may prefer our related Brainscape-certified flashcards:
1
Q

At the first encounter, specific/acquired immunity will provide a ______ response to a threat.

A

mild, slow.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

During the second encounter with a m/o, specific or acquired immunity provides a ______ response.

A

2nd is quick, enhanced response

~ basis for vaccination

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Humoral Immunity is also known as ______________.

A

Antibody Mediated immunity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Antibody Mediated immunity’s goal is to eliminate ______.

A

extracellular pathogens, like m/o and toxins.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

The cells of Humoral / Antibody Mediated immunity are called ________.

A

B-lymphocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

B-lymphocytes, the cells of _________ are made in the ______ and mature in the ________.

A

Humoral or Antibody Mediated immunity;

bone marrow; bone marrow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

The goal of Cell Mediated Response is to protect against

A
intracellular pathogens, like
     infected cells
     abnormal cells (cancer, tumor)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

The cells of Cell Mediated response are called ________.

A

T-lymphocytes - TH T helper

Tc cytotoxic t-cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

T-lymphocytes are made in the ______ and mature in the ______.

A

bone marrow; thymus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Describe the process of Humoral / Antibody Mediated response.

A
  1. B-cell activation
  2. B-cell makes a memory cell and a plasma cell.
  3. Antibody production
  4. Antibodies bind the antigen.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Describe the process of Cell Mediated response.

A
  1. T-helper cell activates the T-cell.

2. Memory cells are made.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Specific / Acquired / Adaptive Immunity is:

A

not w/us at birth; a TAILORED response to a threat. It has memory.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is something that both humoral and cell mediated response immunity have?

A

memory cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

The secondary lymphoid organs include:

A
nodes (lymph)
spleen
tonsils
adenoid
appendix

(places where lymphocytes get together)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

The primary lymphoid organs include:

A

bone marrow and thymus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

define antigen

A

antigen - a molecule that generates antibody production

(bacteria and viruses carry antigens)

17
Q

Antigens must be

A

large molecules with variety

(proteins and complex polysaccharides)

18
Q

An epitope is

A

the place where the antibody binds to the antigen.

19
Q

The best antigens are ______.

A

proteins

20
Q

Antibodies are ______ in a Y-shape.

A

proteins

21
Q

Variable antibodies are called ____.

A

FAD

22
Q

Constant antibodies are called ____.

A

FC

23
Q

Plasma cells secrete ______.

A

Plasma cells secrete antibodies.

24
Q

The top of the Y antibody is the ______ region.

A

top = variable region

25
Q

The bottom of the Y antibody is the ______ region.

A

bottom is the constant region

26
Q

There are how many classes of Antibodies? What determines the class?

A

5 / constant

27
Q

antibodies are proteins that ____ the antigen so _____ can get rid of it.

A

tag / immune system

28
Q

What are the outcomes of an antigen being bound by antibodies?

A
  1. Neutralize / immobilize bacteria by binding to the pili or flagella.
  2. Agglutination - Ab bind to Ag and clump it to make it bigger and easier to find. Instead of having to run around the whole body to find all the little ones, they can find one big one.
  3. Precipitation - clump fluids together into a soluble molecule.
29
Q

List the Protective Outcomes of Ag-Ab binding.

A
  1. Opsonization
  2. Complement activation
  3. Antibody-Dependent Cellular Cytotoxicity (ADCO)
30
Q

What are antibodies good for? (7)

A
neutralize
immobilize bacteria
precipitate toxins
agglutinate
opsonization
activate complement
activate ADCC
31
Q

What is the first Ab made during an infection?

A

IgM

32
Q

chars of IgM

A

only Ab made by fetuses
huge mc’s
not specific –> not good antibodies
pentamer

33
Q

chars of IgG

A
only Ab can cross the placenta
most specific Ab or best Ab
memory cells make IgG
dominant Ab in circulation - 80-85%
monomer
the Ab of memory!!
34
Q

chars of IgA

A

bound in body secretions, like breast milk, mucous, tears, saliva
monomer

35
Q

Ig D chars

A

bound to B-cells

36
Q

IgE chars

A

allergic reactions
bind to the allergen
FC region pops histamine cells, leading to an allergic reaction

37
Q

Clonal selection

A

only B-cells that can respond to Ag threat will be the ones that are ACTIVATED (have the appropriate receptors).

the “chosen cell” replicates itself, then the daughter cells make plasma cells

multiplication of specific B-cells that bind to the Ag

reqs the presence of Ag or it will stop