Ch 143: Prostate

Question 1

Embryologic derivative of the prostate

Answer 1

Endoderm (gut tube)

Question 2

________ exposure initiates the first stage of prostate organogenesis

Answer 2

Androgen

Question 3

T / F: Mesenchymal condensation occurs in males and females

Answer 3

TRUE

Mesenchymal condensation occurs in males and females, so it is not sufficient to drive prostate development but may be necessary.

Question 4

Determines branching pattern in the prostate

Answer 4

Nkx3.1

Question 5

Required for bud growth and branching as well as ductal outgrowth

Answer 5

Sox9
- induced via mesenchymal dependent FGF signaling
- crucial for the initiation of prostate epithelial lineage

Question 6

Two major cell types in prostatic epithelium

Answer 6

(1) epithelial cells
(2) stromal cells

Question 7

“Work horse” of the prostate gland

Answer 7

Luminal epithelial cells
- responsible for epithelial barrier integrity and production of prostatic secretion

Question 8

What is the most active form of the androgen in the prostate?

Answer 8

DHT (dihydrotestosterone)