Ch 12 Nonsteroidal Antiasthma Agents

Question 1

Indications for nonsteroidal antiasthmas?

Answer 1

Prophylactic management of mild persistent asthma: controller, not a reliever!

Question 2

Cromolyn?

Answer 2

Inhibits mast cell degranulation (late phase asthma)
Children age 2 and up
Safe drug!

Question 3

Zileuton?

Answer 3

Brand name: Zyflo (oral)
Inhibits 5-LO
Age 12 and up
MUST ensure that liver function is not affected!!! Before and during treatment

Question 4

Interactions of zileuton (Zyflo) with other drugs?

Answer 4

Theophylline can increase

Prothrombin time can also be increased (warfarin)

Question 5

Zafirlukast?

Answer 5

Brand name: Accolate (oral)
Children 5 and up
Must ingest before or after eating because bioavailability with food is decreased

Question 6

Montelukast?

Answer 6

Brand name: Singulair (oral)

Safest! Age 0.5 years and up

Question 7

Omalizumab

Answer 7

Brand name: Xolair (SubQ injection)

Step 5/6: age 12 and up