ch 12 Flashcards
cardiac muscle
found only in the heart moves blood
skeletal muscle
attached to bones, controls voluntary movement
smooth muscle
muscle of internal organs, controls involuntary movement
striated muscle
muscle with alternating light and dark bands
examples of striated muscle
skeletal, cardiac
voluntary muscle
muscle that contracts on command of somatic nerve
which is the only muscle type that contracts on command of. a somatic nerve
skeletal
involuntary muscle
muscle that contracts without conscious effort
tendons
connect muscle to bones
ligaments
connect bones to bones
origin
muscle attachment closest to trunk or more stationary bone
insertion
more distal or mobile muscle attachment
flexor muscle
muscle connected by a flexible joint that move the bones closer together
extensor muscle
muscle that increases joint angle
antagonistic muscle group
pairs of muscles with opposing actions
muscle fibers
cells forming skeletal muscle tissue
satellite cells
stem cells aiding muscle growth and repair
fascicles
bundles of adjacent muscle fibers
sarcolemma
cell membrane of a muscle fiber
sarcoplasm
cytoplasm with a muscle fiber
myofibrils
main intracellular structures in striated muscles
sarcoplasmic reticulum
endoplasmic reticulum surrounding myofibrils
terminal cisternae
longitudinal tubules with enlarged end regions
transverse tubules
extensions fo membrane for rapid AP transmission
what do transverse tubules allow for
AP’s to move rapidly from cell surface into interior of fiber so they reach terminal cisternae
sarcomere
functional unit of muscle contraction
myosin
motor protein with heavy and light chains
actin
thin filaments forming muscle structure
crossbridges
connections between myosin heads and actin
power strokes
myosin movement pushing actin during contraction
calcium- troponin complex
triggers muscle contraction by exposing actin
relaxation
release of tension after muscle contraction
calcium decrease
essential for muscle relaxation and contraction termination
rigor state
myosin head tightly bound to G-actin without nucleotides
ATP binding
causes myosin head to release from actin
ATP hydrolysis
Myosin rotates, preparing for the next cycle
calcium and Pi release
triggers myosin to swivel and generate force
excitation contraction coupling
process linking muscle action potential to contraction
acetylcholine
neurotransmitter released from somatic motor neurons
depolarization
increased Na influx starts action potential
sarcoplasmic reticulum
stores calcium ions for muscle contraction
troponin
binds calcium allowing muscle contraction to occur
Calcium ATPase
pumps calcium back into SR
crossbridge release
myosin detaches from actin during muscle relaxation
twitch
single contraction-relaxation cycle in muscle fiber
latent period
time between action potential and muscle tension onset
phosphocreatine
high energy molecule providing phosphate to ADP
anaerobic glycolysis
energy production without oxygen access
Central fatigue
fatigue originating from CNS
peripheral fatigue
Fatigue occurring at neuromuscular junction or muscle.
pH
only a cause of central fatigue in extreme circumstances
what could peripheral fatigue come from
glycogen depletion
slow twitch fibers
type 1 fibers, fatigue-resistant, suited for endurance
fast twitch fibers
type 2 fibers, develop tension quickly, fatigue faster
type 2A fibers
fast twitch oxidative-glycolytic
type 2B
fast twitch glycolytic
2A vs 2B
2B develops twitch faster, split atp faster
myoglobin
oxygen-binding pigment enhancing oxygen delivery in muscles
summation
increased force from rapid action potential firing
tetanus
state of maximal contraction without relaxation
single-unit smooth muscle
contracts as a unit via gap junction
multi-unit smooth muscle
cells function independently, requiring fiber recruitment
autonomic nervous system
controls smooth muscle involuntarily without specialized regions
calcium cascade
process ending with myosin light chain phosphorylation
sarcomeres
structural units absent in smooth muscle fibers
actin to myosin ratio
10-15 actin per myosin in smooth muscle
tropomyosin
present in smooth muscle
cytoskeleton
extensive network providing structural support in cells
dense bodies
proteins anchoring actin filaments within smooth muscle
sarcoplasmic reticulum
variable network of tubules for calcium storage
caveolae
invaginations in smooth muscle cell membranes
myosin phosphorylation
increases ATPase activity, enhancing muscles contraction
dephosphorylation
removes phosphate, reducing myosin ATPase activity
latch state
maintains tension with minimal ATP consumption
MLCK
myosin light chain kinase, initiates contraction
MLCP
myosin light chain phosphotase, regulates relaxation
calmodulin
calcium-binding protein activating MLCK in smooth muscle
electromechanical coupling
electrical signal initiating smooth muscle contraction
graded contraction
variable calcium entry leads to different contraction lengths
Calcium-induced calcium release
Ryr opens in response to calcium influx
voltage-gated calcium channels
open in response to cell membrane depolarization
ligand-gated calcium channels
Open upon ligand binding to receptors.
stretch-activated channels
respond to mechanical stretch, important in blood vessels
membrane potentials
influence action potential initiation in smooth muscle
slow wave potential
cyclic depolarization and repolarization in smooth muscle
pacemaker potentials
regular depolarization reaaching action potential threshold
chemical signals
influence smooth muscle activity, can be excitatory or inhibitory
epinephrine
binds to receptors causing contraction or relaxation
IP3
triggers calcium release from the sarcoplasmic reticulum
DAG
inhibits MLCP promoting muscle tension
cAMP
Promotes relaxation by decreasing calcium concentration.
Paracrine Signals
Local signals affecting smooth muscle function.
nitric oxide
Relaxes smooth muscle, synthesized in blood vessels.