Ch 11 part 2 Flashcards

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1
Q

Second Part of James-Lange Theory

A
  • Not only does the physiological come first, but what your body is doing tells your body how to feel
  • So not only does the physio part come first, it also tells you how to feel
  • Unlikely for mild emotions like mild fear, anger and happiness
  • But for more severe emotions
  • Panic disorder is marked by extreme SNS arousal and consequent identification of the feeling of fear
  • stimulation of prefrontal cortex in a surgery patient induced laughter and reason for laughter
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2
Q

Brain Areas Associated with Emotion [placeholder]

A

.

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3
Q

Amygdala

A

Very important for emotion

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4
Q

Limbic system

A

All these parts are associated with emotion

forebrain areas that form a border around the brain stem, are critical for emotions (especially amygdala)

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5
Q

Cingulate Cortex

A
  • People who have damage here don’t get tense or angry anymore
  • This makes you tense and angry
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6
Q

Hypothalamus

A

The 4 F’s

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7
Q

Somatosensory Cortex

A
  • Not in limbic system
  • Sense of touch linked to emotion
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8
Q

Medial Frontal Cortex

A
  • Not in limbic system
  • When people have damage here they have a hard time identifying angry facial expressions
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9
Q

Insular Cortex

A
  • People who have damage here don’t experience disgust or recognize events that trigger disgust, e.g, nausea, sounds of someone vomiting, etc.
  • Responsible for disgust
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10
Q

Right Hemisphere

A
  • the right seems to be more emotional than the left hemisphere especially when we have more negative emotions
  • especially activated by unpleasant emotions
  • inactivate and people do not experience strong emotions and can’t remember feeling them
  • crying or laughter activates the right amygdala
  • noting emotional expression in other people’s faces activates your right temporal cortex
  • left hemisphere damage allows the right to better detect emotional expressions (you actually appear to be more sensitive to emotions)
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11
Q

Stress and Health [placeholder]

A

.

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12
Q

Stress

A
  • When your body is responding to any type of demand
  • Can be physical psychological or both
  • Two types of stress, distress, and eustress
  • The greatest stressors are unpleasant stress
  • Stress activates the stress activates the ANS (Autonomic Nervous System) and hypothalamic-pituitary-adrenal (HPA) axis
  • ANS reacts first
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13
Q

Psychosomatic illnesses

A
  • are physiological illnesses influenced by personality, emotions, or experiences
  • This does not make a psychsomatic illness imaginary!
  • In fact, most illnesses do have a psychsomatic component
  • Common cold, cancer, AIDS
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14
Q

Stress Activates the ANS and the HPA Axis

A

The ANS reacts quickly to acute stressors and activates the SNS

  • HPA Axis is slower to respond

Release of CRF from hypothalamus causes release of ACTH from pituitary and release of cortisol from adrenal cortex

cortisol elevates blood sugar and enhances metabolism – good in proper amounts

Brief activation of SNS or HPA strengthens immune system

  • But, chronic stress results in high cortisol levels which can be harmful to the immune system
  • Cortisol is not bad for you. Too much cortisol is bad for you
  • Cortisol helps your body get ready to fight or to flee
  • Cortisol strengthens the immune system
  • Corticotropin Releasing Factor

ACTH (Adrenalcorticaltropin)

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15
Q

Stress and Health Cont… (Info Dump)

A
  • 1950s – psychologists found 1st evidence that stress can lead to ulcers
  • yoked rats: rat who could run in wheel to avoid shocks when he heard a warning tone developed fewer ulcers than rat who had no control

—> no ulcers in any rat if prefrontal cortex was damaged, perhaps due to reduced emotional reaction

  • They gave the rates with the the wheel hope…(locus of control). Hope is a protective factor against degeneration
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16
Q

Stress and Health conti. (Part 2) {info dump}

A
  • Ulcer caused by PNS (Parasympathetic Nervous System) rebound during rest period between shock trials
  • PNS rebound is when the PNS is overshooting

—> During stress stomach secretions are inhibited (why?)

—> After stress, a greater than normal amount of stomach secretions occur due to a rebound effect

—> in absence of food, the lining of stomach is attacked by so much stomach acid and it causes an ulcer

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17
Q

Stress and Health cont. (Part 3) {info dump}

A

Heart disease

  • Anger reduces blood flow to your heart which causes a heart attack (type A personality)
  • facial expressions of anger produce inadequate blood flow to heart, a precursor to serious heart attacks

Social support correlated with better health

  • keeps heart rate and blood pressure low
  • people in successful marriages tend to be healthier

—> stronger for men, perhaps because women tend to find support from friends more often than men

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18
Q

Voodoo Death {info dump}

A
  • Documented deaths when healthy person believes a curse has been put on them and they will die
  • Similarly, we’ve known people who “held on” to see a grandchild born, and those who “give up” and die

-> may be due to SNS response followed by PNS (Parasympathetic Nervous System) rebound

—> Richter (1957): combination of whisker trim and having to swim led to heart stoppage in rat within a minute or so from apparent massive PNS rebound response to strong SNS activation (heart stopped!)

—> but rat who has been rescued from water several times before trim survived for several hours

  • However, most human heart attacks are due to SNS disruption of normal beating of heart, not rebound PNS
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19
Q

What is the Immune System? [placeholder]

A

.

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20
Q

Leukocytes

A
  • Aka white blood cells protect body against intruders (bacteria, viruses, parasites, fungi, etc.)

—> if too weak, viruses and bacteria create damage

—> if too strong, we have autoimmune disease where immune system cells attack normal cells

  • Leukocytes (white blood cells) patrol blood and other fluids killing antigens (surface proteins on viruses, bacteria, organ transplants and other intruders)
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21
Q

Antigens

A

surface proteins on viruses, bacteria, organ transplants and other intruders

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22
Q

What is the Immune System? cont. [placeholder]

A

.

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23
Q

Types of leukocytes

A

Macrophage cells, B cells, Memory cells (formed by B cells), Cytotoxic T cells, Helper T cells, Natural Killer Cells, Cytokines

24
Q

Macrophage cells

A
  • surround and digest a bacterium or other intruder
25
Q

B cells

A
  • attach to virus and produces antibodies to attack antigens

—> The immune system has memory cells that remember specific antigens so they can be identified and remember what killed them last time so they can do it more quickly the 2nd time around – vaccinations use this principle.

26
Q

memory cells

A
  • remember specific antigens so they can be identified and remember what killed them last time so they can do it more quickly the 2nd time around – vaccinations use this principle.
27
Q

Cytotoxic T cells

A

directly attack intruder cells

28
Q

Helper T cells

A
  • stimulate other T cells or B cells to multiply
29
Q

All of the leukocytes listed only attack…

A

a specific type of intruder, they have targets

30
Q

Natural Killer Cells

A
  • are blood cells that attach to tumor cells and cells infected with viruses

—> non-specific, attach to several kinds of intruders

—> Fight off cancer

31
Q

Cytokines

A
  • are chemicals released by T cells to fight infections
  • stimulates vagus nerve to tell brain the body is ill
  • brain can induce fevers to fight infections (most viruses lose efficiency at high temps) or cause sleepiness and decrease muscle activity and sex drive to conserve energy
32
Q

Effects of Stress on Immune System

A
  • Long-term stress increases cortisol too much, which reduces synthesis of proteins, including proteins of immune system

—> lower levels of B, T and natural killer cells among Three Mile Island residents one year after accident

—> 50% drop in T cells after nine months in Antarctic isolation

33
Q

Effects of Stress on Immune System

A
  • Stressful experiences lasting more than a month increased risk of illness

—> particularly destructive in people that resign themselves, i.e., people are healthier when they attack the problem

—> College kids injected with a Pokeweed mitogen fought it off much better when it was NOT exam time!

34
Q

Effects of Stress on Immune System cont.

A
  • High cortisol levels impair memory

—> prolonged high levels increase vulnerability of hippocampal neurons and toxins can kill them

—> may be responsible for deterioration of hippocampus, leading to higher cortisol levels and more hippocampus damage, a vicious cycle

—> people with highest cortisol levels tend to have smallest hippocampus and greatest memory problems

35
Q

Post-Traumatic Stress Disorder

A
  • Occurs in some people who suffer trauma of being severely injured or threatened or in people who have seen other people harmed or killed

—> e.g.: common among soldiers, rape victims, kidnap victims and torture victims

—> frequent flashbacks and nightmares about the event

—> avoidance of reminders of the event

—> exaggerated arousal in response to noises and stimuli

—> Yet not all who experience a trauma get PTSD, so there may be a biological vulnerability for developing PTSD

36
Q

Attack and Escape Behaviors

A
  • Most “emotional” animal behavior falls under the categories of attack or escape (fight or flight). We assume the corresponding emotions are anger and fear
  • Cat displays both attack and escape behaviors when “playing” with mouse
  • Attack behavior usually triggered by pain or threat, especially when primed

—> e.g.: hamster attacks second intruder faster

—> personal insult leads to increase in aggressive behaviors for short time

37
Q

Heredity and Environment in Violence

A

Brodkin et al (2002): identified specific genes in mice associated with likelihood of attack

  • Aggressive and adult criminal behavior: genetics

—> children resembled biological parents more than adopted

—> monozygotic twins resembled each other more than dizygotic twins
but no biological differences found so far for juvenile crime; it’s thought that is a result of environment

38
Q

How do genes account for violence?

A

Perhaps by influencing body size and probability of winning a fight: Taller boys tend to be more aggressive at age 3 are still aggressive at age 11, regardless of height difference

39
Q

Testosterone and Aggression

A
  • Most animal fighting = males fighting for mates or females defending their babies

—> Males fight more during the mating season, which is also when they have more testosterone

  • Male humans fight more and get arrested more than females

—> highest rates of violence in males 15-25 years old who also have the highest testosterone levels

  • High testosterone levels associated more with rape and murder than nonviolent crimes
  • Injections of testosterone caused women to increase heart rate when viewing angry faces
  • Overall, testosterone is definitely linked to aggression, but probably doesn’t directly cause it. Rather it probably intensifies the way you react to aggressive stimuli.
40
Q

Brain Abnormalities and Violence [placeholder]

A

.

41
Q

Intermittent Explosive Disorder

A
  • results in outbursts of violent behavior without provocation
  • in a few cases it is linked to temporal lobe epilepsy
  • outbursts eliminated in a handful of case study patients after surgery to destroy part of the amygdala on both sides of the brain
  • damage to prefrontal cortex also leads to more fighting and threats and socially inappropriate behavior (but probably as a result of less social inhibition than as a result of feeling more violent, since all sorts of inappropriate social behavior increase).
42
Q

Serotonin Synapses and Aggressive Behavior - Animals [info dump]

A
  • Low serotonin release in animals is related to decreased inhibition of impulses, increased aggression

—> social isolation decreases serotonin release in male mice and they will fight when placed together

—> low release among monkeys predicted aggressive behavior and most died by age 6

—> mice deficient in serotonin receptor 5-HT1B develop cocaine addition quicker, act impulsively in maze tasks and do not delay gratification for larger rewards – this suggests that low serotonin turnover doesn’t lead specifically to violence, but instead to a decreased inhibition of impulses, which often leads to violence.

43
Q

Serotonin Synapses and Aggressive Behavior - Humans

A
  • Low serotonin release in humans related to

—> violent behavior, violent crimes

—> suicide by violent means, increased suicide attempts and rates

—> aggressive behaviors among children and adolescents

—> greater probability of convictions for violent crimes

44
Q

Serotonin Synapses and Aggressive Behavior cont.

A
  • Serotonin is made from tryptophan, an amino acid found in proteins. But in order for tryptophan to cross the bbb to be made into 5HT, it has to cross through an active transport channel that it shares with other amino acids, like the ones found in Nutrasweet and maize (American corn). If your diet is too high in these things, not enough tryptophan can get through, so you may get depleted amounts of 5HT.
  • Low levels of serotonin also associated with depression and psychiatric conditions not related to violence
  • Drop in serotonin levels increases your previous history, e.g., depression, substance abuse or aggression

—> normal people become more impulsive in general

45
Q

2 Escape Emotions: Fear and Anxiety

A
  • Fear is usually temporary, anxiety more long lasting
  • We have at least one built in, unlearned fear – the Startle response is an unlearned response to loud, unexpected noises

—> Even newborns do it – you tense up, especially in your neck (why?)

—> The startle response is more vigorous if already tense

  • Learned fears are associated with more activity in the amygdala

—> inputs from vision, hearing and pain

—> outputs control blood pressure, startle reflex and modify interpretation of stimuli

46
Q

Escape Emotions: Fear and Anxiety – animals

A
  • Damage to amygdala and rats still show startle reflex but will not startle to learned fears anymore

—> may lose ability to understand consequences of stimuli

  • Amygdala damage in monkeys and they may lose ability to understand consequences behavior

Klüver-Bucy Syndrome: monkeys are tame and placid
—-> pick up lighted matches, show less fear of snakes and more dominant monkeys

—> lesions also result in friendlier behavior, similar to people who take tranquilizers – lower ability to be scared of rejection or them being aggressive

47
Q

Klüver-Bucy Syndrome

A
  • Monkeys are tame and placid
  • pick up lighted matches, show less fear of snakes and more dominant monkeys
48
Q

Escape Emotions: Fear and Anxiety - humans

A
  • fMRI scans show greater amygdala activity in people when they view emotional facial expressions vs. neutral facial expressions

—> more reaction to fearful than happy faces

—> true even when person cannot consciously identify face

  • Urbach-Weithe disease results in atrophy of amygdala (along with lesions of skin) – rare genetic disorder

—> people do not show strong dislikes and rate pleasant and unpleasant drawings the same - everything is neutral

  • People with amygdala damage rate all faces equally trustworthy and seek help indiscriminately
  • People with excessive fears generally have a hyperactive amygdala
49
Q

Anxiety Reducing Drugs

A
  • Drugs intended to control anxiety alter activity at amygdala synapses
  • Drugs could reduce anxiety by either blocking CCK or increasing GABA; all current tranquilizers for humans are GABA facilitators (still seeking FDA approval on CCK drugs)
50
Q

CCK (cholecystokinin)

A
  • is an important excitatory neurotransmitter that work on the amygdala

—> injections increase anxiety

—> animal research has shown CCK blockers have potential for anxiety reduction

51
Q

GABA

A
  • is the amygdala’s main inhibitory neurotransmitter

—> tranquilizers that reduce anxiety are GABA facilitators

—> injections of GABA blockers can produce panic

52
Q

Anxiety Reducing Drugs cont.

A
  • Benzodiazepines (popular tranquilizers) facilitate transmission of GABA
  • include Valium, Librium and Xanax
  • bind to GABA receptors and alter the shape of receptors so that GABA attaches more easily and binds more tightly

—> promotes chloride ions flow into neuron and hyperpolarizes (inhibits) cell

—> In the amygdala and hypothalamus, this leads to less anxiety. In the thalamus and cortex, induces sleepiness and impairs memory, so side effects

  • alcohol also binds to receptor and facilitates GABA
  • reduces fear and anger, similar to amygdala damage
53
Q

Too much activity in the amygdala can lead to

A

agression and violence

54
Q

Too little activity in the prefrontal cortex can lead to

A

aggression and violence

55
Q

Too much stress is bad for your

A
  • immune system
  • memory