ch. 1 Principles of Safe Prescribing

Question 1

Pharmacodynamics (PD)

Answer 1

What the drug does to the body and/
or disease
* Includes drug’s mechanism of action

Question 2

Pharmacokinetics

Answer 2

What the Body Does to the Drug

Question 3

Examples of these Permeable Membranes

Answer 3

Blood-brain
* Mammary
* Placenta
* Cell membrane * Vessels

Question 4

Tmax

Answer 4

– Time to maximum drug level observed

Question 5

Cmax

Answer 5

– Maximum or peak concentration of a drug
observed after its administration

Question 6

Bioavailability

Answer 6

Percent of dose enter systemic circulation after PO administration of a given dosage form

Question 7

Volume of Distribution

Answer 7

Total amount of drug in body/Drug blood concentration

Question 8

First Pass Effect

Answer 8

Biotransformation and/or excretion of oral drug by hepatic mechanisms
– Occurs prior to entering GI tract – Then transported to interact with
receptors in target tissues

Question 9

Rosuvastatin

Answer 9

20 h
20%

Question 10

Simvastatin

Answer 10

1–2 h
<5%

Question 11

Atorvastatin

Answer 11

14 h
14%

Question 12

Pravastatin

Answer 12

1–2 h
17%

Question 13

which statin has Lower bioavailability, higher first pass effect *

Answer 13

Simvastatin

Question 14

which statin has Higher bioavailability, lower first pass effect *

Answer 14

Atorvastatin