CGRP and Migraine

Question 1

features of migraine that make it a compelling drug target

Answer 1

• Common disorder
• Severe/disabling symptoms
• High annual cost
• Treatments options are limited/ineffective
• Large potential market
• Robust targets for drug development

Question 2

List two advantages of using a monoclonal

antibody to treat migraine.

Answer 2

Safe or proteins that a broken down naturally or don’t cause liver
toxicity
• Fail early due to poor efficacy
• Long lasting or have Very slow clearance
• Good as a preventative or prophylactic

Question 3

List two disadvantages of using a monoclonal

antibody to treat migraine.

Answer 3

•Very expensive (Estimated $8000-$25000)•Difficult to administer (injections)•Slow distribution (are slow to enter tissues and typically don’t enter the brain)•Very slow clearance*

Question 4

Challenges targeting CGRP in migraine

Answer 4

No rodent models for migraine

Telcagepantrequires high doses (low bioavailabilty_)

Question 5

Challenges targeting CGRP in migraine

Answer 5

No rodent models for migraine
Telcagepantrequires high doses (low bioavailabilty_)
Olcegepantis not bioavaliable
Telcagepantterminated due to safety