CF5/ dehydration Flashcards
what emerging CF treatment promotes read through of premature stop codons
ataluren
what emerging treatment increases levels of s-nitroglutathione and increases amount of CFTR
N6002
what are 4 major areas emerging CF treatments are being researched
- gene therapy
- restoring airway surface liquid
- anti-inflammatories
- anti-infectives (new formulations of old antibiotics)
what is an acquired lactase deficiency
a reduction in intestinal brush border enzyme responsible for lactose digestion
what is considered persistant diarrhea
lasting 2 weeks or longer
when are antimicrobials used to treat diarrhea
- clostridium
- giardia
- shigella
why is loperamide not used?
- antidiarrheals do not address underlying cause
2. can cause opiate induced ileus
why are specific rehydration products such as pedialyte recommended over clear liquids such as sprite and soup
rehydration products include necessary electrolytes lost in diarrhea that aren’t in clear liquids
what are the signs and symptoms for mild to moderate dehydration
young children/ infants = thirsty, restless, irritable to touch or drowsy
older children = thirsty, alert but lethargic, postural hypotension (dizzy when stand)
what are the signs and symptoms for minimal dehydration
everything is normal
what are the signs and symptoms for severe dehydration
young children/ infants = drowsy, limp, cold, sweaty, cyanotic extremities, comatose
older children = conscious, apprehensive, cold, sweaty, wrinkled or blue skin of fingers and toes, muscle cramps
what is the heart rate for mild to moderate dehydration
rapid and weak
what is the heart rate for severe dehydration
rapid, feeble, sometimes impalpable
what can occur with a babies skull if they are dehydrated
convex fontanel on top of skull
what BP indicates severe dehydration
systolic less than 90
