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7361 Hem/Onc Block 3 > Cervical Cancer > Flashcards

Cervical Cancer Flashcards

1
Q

5 year survival of cervical cancer is ___ %

A

66.1

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2
Q

Median age at diagnosis of cervical cancer is ___ years old

A

50

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3
Q

Most cervical cancer is localized

a. true
b. false

A

a. true

44% localized
36% regional
16% distant
4% unknown

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4
Q

Use of oral contraceptives for __ or more years is a risk factor for cervical cancer

A

5

Risk factors:

  • HPV infection
  • early sexual activity (<18)
  • multiple sexual partners
  • smoking
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5
Q

__ or more pregnancies is a risk factor for cervical cancer

A

3

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6
Q

Nulliparity increases the risk for cervical cancer

a. true
b. false

A

b. false

decreases risk of cervical cancer

increases risk of ovarian cancer

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7
Q

What age receives 2 doses of Gardasil 9?

A

9-14

0 and 6-12

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8
Q

What age range receives 3 doses of Gardasil 9?

A

15-45

0, 2, and 6 months

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9
Q

3 types of cervical cancer screening?

A
  • cervical cytology (PAP, liquid based)
  • HPV testing
  • cotesting
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10
Q

USPSTF

Age < 21 needs no screening

a. true
b. false

A

a. true

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11
Q

USPSTF:

Age 21-29 needs PAP how often?

A

every 3 years

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12
Q

USPSTF:
Post hysterectomy pts need no screening

a. true
b. false

A

a. true

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13
Q

USPSTF:

Pts age 30-65 need what screening?

A

PAP every 3 years OR HPV test every 5 years OR contesting every 5 years

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14
Q

ACS:

Pts < __ years old need no screening

A

25

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15
Q

ACS:

Pts age 25-65 need what screening?

A

PAP every 3 years OR HPV test every 5 years OR contesting every 5 years

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16
Q

___ is 80-90% of cervical cancer cases

a. adenocarcinoma
b. mixed carcinoma
c. squamous cell carcinoma

A

c. squamous cell carcinoma

17
Q

Which of the following is fertility sparing surgery?

a. cone biopsy/conization
b. ablation
c. radical vaginal trachelectomy
d. simple hysterectomy

select all that apply

A

a-c

18
Q

Cervical cancer:

___ is radiation and chemotherapy given together to improve response rates and survival

A

chemosensitization

initiate chemo within 24-48hrs of starting radiation

transient increase in pain

19
Q

Chemosensitization for cervical cancer is a ___ based therapy

A

platinum

20
Q

Chemotherapy has an extensive role in cervical cancer

a. true
b. false

A

b. false

limited role in cervical cancer

21
Q

What is the primary treatment for stage IIB, III, and IV advanced stage?

A

radiation

pelvic or extended EBRT plus concurrent platinum containing chemosensitization and brachytherapy

22
Q

Stage 0 treatment?

A

excision or ablation

23
Q

Stage I-IIA (early stage) Tx?

A

surgery or radiation

fertility desired: cone biopsy or radical trachelectomy
fertility not desired: simple hysterectomy

24
Q

What Tx is given following surgery if positive lymph nodes, positive surgical margins, or negative lymph nodes with high risk features?

A

adjuvant radiation

25
Q

Focus on ___ for stage IVB (advanced) or recurrent?

A

palliation

chemotherapy for palliation

26
Q

Preferred Tx for advanced/recurrent chemotherapy?

A

platin + paclitaxel + bevacizumab

carboplatin or cisplatin

27
Q

Cisplatin:

What lab is used to monitor for nephrotoxicity?

A

CMP

28
Q

Cisplatin:

What lab is used to monitor for myelosuppression?

A

CBC with diff

29
Q

Doses > __ mg/m2 of cisplatin are rare and should be verified with provider

A

100

30
Q

With cervical cancer and cisplatin Tx pre-hydrate with what?

A

potassium and magnesium per liter

post-hydration for total of 1-3 liters of fluid

31
Q

Premedicate with what for paclitaxel therapy?

A

H1 antagonist, H2 antagonist, dexamethasone

diphenhydramine, famotidine, steroid

32
Q

Paclitaxel is __ emetic risk

a. high
b. low

A

b. low

Monitoring:

  • myelosuppression
  • hypersensitivity rxns
  • peripheral neuropathy
  • hepatotoxicity
33
Q

Low risk cervical cancer is monitored every __ months for the first __ years, then annually

A

6, 2

34
Q

High risk cervical cancer is monitored every __ months for 2 years, then every __ months for 2-5 years, then annually

A

3, 6

35
Q

What is preferred second line therapy for PDL1 positive of MSI-H/dMMR tumors?

A

pembrolizumab

36
Q

pembrolizumab:

A PDL1 positive score is a combined positive score (CPS of >= ___)

A

1

7361 Hem/Onc Block 3 (9 decks)

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