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7361 Hem/Onc Block 3 > Breast Cancer > Flashcards

Breast Cancer Flashcards

1
Q

Breast cancer is the most common type of cancer globally.

a. true
b. false

A

a. true

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2
Q

What typeof gene is p53?

A

tumor suppressor gene

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3
Q

The normal BRCA gene helps __ repair

A

DNA

tumor suppressor gene

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4
Q

Age >= ___ is a risk factor for breast cancer

A

50

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5
Q

Early menarche at <= __ years old is a risk factor for breast cancer

A

12

Endogenous estrogen exposure:

  • early menarche (<=12)
  • late menopause (>=55)
  • late 1st pregnancy (> 30)
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6
Q

Being HR __ is a poor prognostic factor

a. positive
b. negative

A

a. positive

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7
Q

Biomarker testing is a NCCN strong consideration for tumor size > __ cm and risk score determines therapy decisions`

A

0.5

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8
Q

__ is highly recommended

a. breast self exam
b. breast self awareness

A

b. breast self awareness

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9
Q

Which guideline does not recommend clinical breast exam?

a. ACS
b. USPSTF
c. NCCN

select two

A

a, b

NCCN:

  • age 25-39 every 1-3 years
  • age >=40 annually
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10
Q

NCCN recommends mammography annually for what age?

A

> = 40

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11
Q

___ is used to assess extent of disease

a. ultrasound
b. MRI

A

b. MRI

assess extent of disease
evaluate abnormalities found on other diagnostic tools

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12
Q

__ is used for pathology assessment

a. ultrasound
b. MRI
c. biopsy

A

c. biopsy

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13
Q

Give chemotherapy in breast cancer with tumors of what size?

A

> 1cm

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14
Q

What is general treatment for HR+, LN-, HER2- with RS < 26?

A

adjuvant endocrine therapy

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15
Q

What is general treatment for HR+, LN-, HER2- with RS >26

A

adjuvant endocrine therapy +/- chemo

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16
Q

What is general treatment for HR+, LN-, HER2+ with T<=0.5 or T 0.6-1cm?

A

T <=0.5cm: consider adjuvant endocrine therapy +/- chemo + trastuzamab

T 0.6-1cm: adjuvant endocrine therapy +/- chemo +/- trastuzamab

17
Q

What is general treatment for HR+, LN-, HER2+ with T > 1cm?

A

adjuvant endocrine therapy + chemo + trastuzamab

18
Q

What mab is +/- with LN positive?

A

pertuzumab

19
Q

Taxanes cause what AE?

A

peripheral neuropathy

20
Q

What is the general treatment of choice for stage I or II adjuvant chemotherapy for breast cancer?

A

taxane +/- anthracycline

doxorubicin +
cyclophosphamide for 4 cycles then weekly paclitaxel for 12 cycles

docetaxel + cyclophosphamide

21
Q

Which class of endocrine therapy has increased CYP2D6 inhibitor interactions?

a. LHRH agonists
b. SERMs

A

b. SERMs

22
Q

3 LHRH agonists:

A

goserelin
leuprolide
triptorelin

23
Q

which class of endocrine therapy causes bone loss with long term use?

a. LHRH agonists
b. SERMs

A

a. LHRH agonists

24
Q

What is the only LHRH agonist approved for breast cancer?

A

goserelin

25
Q

Which aromatase inhibitor is steroidal?

a. anastrazole
b. letrozole
c. exemestane

A

c. exemestane

26
Q

Aromatase inhibitors reduce cardiovascular risk

a. true
b. false

A

`b. false

can cause cardiovascular risk

27
Q

Tamoxifen can be used for a total of __ years

A

10

28
Q

Which drug class is a category I based recommendation for postmenopausal endocrine Tx?

A

aromatase inhibitors

29
Q

HER2 targeted therapy:

Which drug is used for EARLY adjuvant/neoadjuvant and metastatic?

A

pertuzumab

30
Q

Trastuzamab should be used concomitantly with an anthracycline.

a. true
b. false

A

b. false

AVOID concomitant use with anthracycline

31
Q

What route is trastuzamab administered?

A

IV

IV load over 90mins, maintenance over 30 mins

32
Q

Consider __ for one year after trastuzumab for stage 3 breast cancer

A

naratinib

33
Q

Is endocrine therapy given before or after chemotherapy for metastatic breast cancer?

A

after

34
Q

Which metastatic breast cancer site responds well to endocrine therapy?

a. bone
b. visceral
c. brain

A

a. bone

35
Q

Which drug is used for triple negative breast cancer and PDL1+?

A

atezolizumab

36
Q

Which class is given to stop or control endocrine therapy resistance wit HR+, HER2-?

A

CDK4/6 inhibitor (-ciclib)

class effect:
neutropenia and fatigue
37
Q

What drug is used for PIK3CA mutation?

A

alpelisib

38
Q

What is treatment of choice for resectable breast cancer?

A

surgery

39
Q

What is treatment of choice for early stage breast cancer?

A

anthracycline plus taxane

adjuvant chemotherapy

7361 Hem/Onc Block 3 (9 decks)

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