Cerebrovascular Accudent (sroke)

Question 1

What vascular perfusion or ischemia be due to?

Answer 1

global involving the entire brain Focally brain parenchyma

Question 2

What is the most important and common thombotic infarcts(ischemia)?

Answer 2

Atherosclerosis

Question 3

Where the most common places for artherosclerosis?

Answer 3

middles cerebral artery internal carotid basilar

Question 4

What are pale infarcts mostly due to?

What is the most commom cause of red (hemorrhagic) infarcts?

Answer 4

pale infarcts are Due to Occlusive atherosclerotic thrombosis, appars soft pale and swollen

Red hemorrhagic infarts venous obstruction in people who hypercoagulable conditions.

Question 5

What is this representing?

Answer 5

Dying nuerons By ~12 hrs, neurons appear disoriented with red cytoplasm and pyknotic nuclei

note the large open nuclei and pale cytoplasm

Question 6

What is this representative of?

Answer 6

Proliferation of capillaries, mobilization of microglia (gitter cells), liquefaction

24 hrs - 2 weeks

Question 7

What is this representative?

Answer 7

As ischemic change progresses, neutrophils (arrows) migrate to the site and increase in number during the next 24 to 48 hours.

There is associated edema in the area of ischemic necrosis which worsens with time accompanied by breakdown of axons and myelin , becoming liquefactive.

Question 8

What is this?

Answer 8

Organizing (older) infarct is shown in the image of the gross specimen appearing cystic and orange (arrow) due to breakdown of blood.

Yellow discoloraztion is do to old hemmorage red cells that are dying