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Neuroscience > Cerebrospinal Fluid and Ventricles > Flashcards

Cerebrospinal Fluid and Ventricles Flashcards

1
Q

WHAT IS PIA MATER

A

THIN LAYER OF CT ADHERENT TO SURFACE OF CNS PARENCHYMA

- vascularized

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2
Q

WHAT 2 LAYERS OF CT FORM THE LEPTOMENINGES

A

PIA MATER AND ARACHNOID

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3
Q

WHAT IS ARACHNOID MATER

A

THIN LAYER OF CT ADHERENT TO DURA BY DESMOSOMES

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4
Q

WHAT DOES SUBARACHNOID SPACE CONTAIN

A

CSF, BLOOD VESSELS, SPINAL NERVES, ARACHNOID TRABECULAE

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5
Q

WHAT ARE ARACHNOID TRABECULAE

A

THIN COLLAGENOUS CT EXTENSIONS OF ARACHNOID MEMBRANE

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6
Q

WHAT IS DURA MATER

A

MOST EXTERNAL, THICK AND FIBROUS CT ADHERENT TO BONE OF SKULL W/IN CRANIAL CAVITY
- separated from vertebra by the epidural space within vertebral canal and contains fat

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7
Q

WHAT IS CEREBROSPINAL FLUID

A

CLEAR, COLORLESS FLUID PRODUCED BY CHOROID PLEXUSES WITHIN VENTRICLE

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8
Q

FUNCTIONS OF CSF

A

Surround and permeate the entire CNS
Protects & supports the CNS
Brings in nourishment to the CNS parenchyma
Modulates and regulates intracranial pressure changes
Transport neuroendocrine and neurotransmitters
Maintains ionic balance

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9
Q

CIRCULATION AND ABSORPTION OF CSF

A

CIRCULATES TO SUBARACHNOID SPACE AND IS ABSORBED BACK TO VENOUS SINUSES

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10
Q

WHERE IS THE CHOROID PLEXUS PRODUCING CSF

A

LATERAL, 3RD AND 4TH VENTRICLES

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11
Q

ENDOTHELIUM CELLS OF CHOROID CAPILLARIES ARE

A

FENESTRATED WITH NO TIGHT JUNCTIONS

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12
Q

EPITHELIAL CELLS OF CHOROID PLEXUS

A

HAVE TIGHT JUNCTION ON VENTRICULAR SURFACE MICROVILLI

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13
Q

WHAT DOES THE COMBINATION OF ENDOTHELIAL CELLS OF CHOROID CAPILLARIES AND EPITHELIAL CELLS OF CHOROID PLEXUS PRODUCE

A

A SEMI PERMEABLE MEMBRANE

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14
Q

CSF CIRCULATION

A

CSF circulate from the ventricular system to the subarachnoid space by arterial pulsations of blood in the choroid plexus increases CSF pressure which surges towards the lateral aperture and depend also on the cardiac systole

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15
Q

WHERE IS THE PASSAGE BETWEEN CENTRAL CANAL AND SUBARACHNOID SPACE IN SOME ANIMALS

A

CONUS MEDULLARIS

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16
Q

WHERE IS THE MAJOR SITE OF CSF ABSORPTION

A

ARACHNOID GRANULATION

- collection of arachnoid villi in venous sinuses and cerebral veins

17
Q

WHAT PERMITS FLOW OF CSF INTO LUMEN OF SINUS

A

ONE WAY VALCE WHEN CSF PRESSURE EXCEEDS VENOUS PRESSURE

18
Q

HOW DO THE ONE WAY VALVES INTO LUMEN OF SINUS CLOSE

A

THE ARACHNOID VILLI COLLAPSE WHEN BLOOD PRESSURE EXCEEDS CSF PRESSURE

19
Q

WHAT ARE THE THREE EXTRA CELLULAR FLUID COMPARTMENTS

A

PLASMA, CSF AND EXTRACELLULAR FLUID

20
Q

BLOOD BRAIN BARRIER

A

BETWEEN PLASMA AND EXTRACELLULAR FLUID OF INTERSTITIAL SPACE AT CAPILLARY LEVEL

21
Q

WHAT MAKES UP BBB

A

NONFENESTRATED, ENDOTHELIAL CELL TIGHT JUNCTIONS

  • surrounded by thick basement membrane
  • layers of astrocyte endfeet processes
22
Q

WHAT PREVENTS IVERMECTIN FROM CROSSING BBB

A

p-glycoproteins

23
Q

FUNCTIONS OF BBB

A 
ISOLATE CNS FROM BLOOD
STABLE ENVIRONMENT FOR NEURONAL FUNCTION
MODULATE GLUCOSE ENTRY INTO CNS
PROTECT NEURONS FROM TOXINS IN BLOOD
SELECTIVE BARRIER
24
Q

WHAT IS THE BLOOD-CSF BARRIER

A

BARRIER BETWEEN PLASMA AND CSF AT CHOROID PLEXUS

25
Q

WHAT DOES BLOOD-CSF BARRIER CONSIST OF

A

TWO CELL LAYER WITH THIN BASEMENT MEMBRANE
- fenestration in vascular endothelial layer and basement membrane
- no tight junctions
cuboidal choroid epithelial layer with tight junctions

26
Q

WHAT IS THE EPENDYMAL-CSF INTERFACE (PIAL-GLIAL MEMBRANE)

A

BETWEEN CSF (SUBARACHNOID SPACE) AND EXTRACELLULAR FLUID IN INTERSTITIAL SPACE

27
Q

WHAT IS THE PIAL-GLIAL MEMBRANE FORMED BY

A

PIA AND ASTROCYTE FOOT PROCESSES

  • permeable, no intercellular junctions
  • metabolite in the csf have access to extracellular fluid in parenchyma
28
Q

WHAT ARE THE EPENDYMAL CELLS LIKE

A

SQUAMOUS, INCOMPLETE INTERECELLULAR JUNCTION, NO BASEMENT MEMBRANE

Neuroscience (10 decks)

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