Cerebral Vascular Diseases

Question 1

Global Cerebral Ischemia

Answer 1

Caused by hypotension–> brain doesn’t get enough blood–> mild (transient confusion) or severe (persistant vegetative or brain death)

Histology

1. Red neurons, neutrophil infiltration (day 1)
2. Necrosis, macrophages, vascular proliferation–> laminar necrosis
3. Loss of necrotic tissue (after 2 wks)

Watershed infarcts–areas most susceptible to hypoxia

-places where two arteries join (ACA/MCA)