Cerebellar Function Flashcards

1
Q

Define: Titubation

A

Tremor of the entire trunk or head during stance or gate.

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2
Q

What are the inputs to the vestibulocerebellum?

A

Primary afferents from vestibular labyrinth/nuclei.

Indirect visual inpur from sup. colliculi and striate cortex.

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3
Q

What is the output from the vestibulocerebellum?

A

Mainly to vestibular nuclei and fastigial nucleus.

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4
Q

What is the function of the vestibulocerebellum?

A

Controls eye movements and position of the head.

regulates gait and posture.

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5
Q

What is seen in lesions involving the vestibulocerebellum?

A
Ataxic gait (wide stance)
Eye movement disorders.
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6
Q

What are the inputs to the spinocerebellum vermis portion?

A

Somatosensory from spinal cord axial proximal body parts.

Vestibular inputs

Facial, visual, auditory input to posterior lobe only.

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7
Q

What are the outputs of the spinocerebellum vermis portion?

A
Via fastigial nucleus to:
Medial motor systems
Vestibular nucleus
Reticular formation
Motor cortex
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8
Q

What is the function of the spinocerebellum vermis portion?

A

Regulates axial and proximal musculature.

Concerned with ongoing motor execution and regulation of muscle tone.

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9
Q

What is seen in lesions of the spinocerebellum vermis portion?

A

Decreased muscle tone
Decreased proximal and axial musculature.
Problems with ongoing motor execution.

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10
Q

What are the inputs to the spinocerebellum paravermal region?

A

Somatosensory from distal body parts.

Input from primary and somatic sensory cortex.

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11
Q

What are the outputs of the spinocerebellum paravermal region?

A

Via intopositus to:
Lateral motor systems
Red nucleus and motor cortex

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12
Q

What is the function of the spinocerebellum paravermal region?

A

Regulates distal muscle.

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13
Q

What is seen in lesions affecting the spinocerebellum paravermal region

A

SEEN IPSILATERALLY TO LESION CAUSING HYPOTONIA.

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14
Q

What are the inputs to the cerebrocerebellum AKA pontocerebellum?

A

Cortical afferents via the pontine nuclei.

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15
Q

What are the outputs of the cerebrocerebellum?

A

Via dentate nucleus:

  • To lateral nucleus of thalamus and red nucleus
  • Ventral lateral thalamus then projects to the premotor and primary motor cortex.
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16
Q

What is the function of the cerebrocerebellum?

A
  • Preperation for movement.
  • Multi joint movement
  • Patients ability to judge elapsed time in non motor task.
17
Q

What is seen in lesions to the cerebrocerebellum?

A

Delay initiating and terminating movements.
Problems with multijoint movement.
Cant judge elapsed time with non-motor tasks (can improve with eyes closed

18
Q

What function do purkinje cells have?

A

Only cell to project out of cerebellar cortex.

19
Q

What function do Granule cells have?

A

Only excitatory cells in cerebellar cortex.

20
Q

What function do Golgi cells have?

A

Affect dendritic input to perkinje cells by inhibiting granular cells.

21
Q

What function do stellate cells have?

A

Affect dendritic integration of purkinje cells.

22
Q

What function do Basket cells have?

A

Make inhibitory synapses near initial segment of the purkinje cell axon.

23
Q

How do mossy fibers affect perkinje cells?

A

Indirectly sends excitatory signals to the granule and golgi cell dendrites. The granule cells are then able to excite the purkinje cells with small ESPSs.
LEARNING

24
Q

Where do climbing fibers originate?

A

Inerior olivary nuclei

Each Purkinje cell only makes one synapse onto a climbing factor. Climbing factors synapse with multiple purkinje cells.

25
Q

What cerebellar effects are seen in alcoholism?

A

Lack of B1 thiamine leads to damages to the anterior lobe of cerebellum.

Causes difficulty with leg control.

26
Q

What cerebellar effects are seen in Frederich Ataxia

A

A recesively inherited disease causing spinocerebellar ataxia.

Caused by trinucleotide GAA repeat on chromosome 9