Cephalosporins

Question 1

Clinical uses

Answer 1

Hospital acquired pneumonias
Meningitis 
Sepsis 
Gonorrhea 
Acute UTI

Question 2

First generation

Answer 2

Cephalexin

Cefazolin

Question 3

Second generation

Answer 3

Cefaclor
Cefuroxime
Structurally related cephamycins : cefoxitin

Question 4

Third generation

Answer 4

Ceftotaxime
Ceftriaxone
Ceftazidmine

Question 5

Fourth generation

Answer 5

Cefepime

Question 6

Cefazolin ; first generation

Answer 6

Surgical prophylaxis
Penetrates most tissues
Sensitive to b-lactamase

Question 7

Second generation

Cefaclor
Cefuroxime active against

Answer 7

Gram negative aerobic organisms

Question 8

Cefoxitin ; second generation

active against

Answer 8

Anaerobes

Question 9

Cefuroxime ; second generation

Answer 9

Crosses BBB , not used for meningitis

Question 10

Active against P aeureginosa

Answer 10

Ceftazidmine ; third generation

Question 11

Gonorrhea
Meningitis but not caused by listeria monocytogens
+ aminoglycosides for p aeurginosa meningitis

Answer 11

Ceftriaxone ; third generation

Question 12

Cefepime ; fourth generation

Answer 12

Gram negative
Gram positive
Gram negative that are resistant