cephalosporins Flashcards
cefazolin
ancef
cephalexin
keflex
cefadroxil
duricef
Examples of 1st generation cephalosporins
cefazolin, cephalexin, cafadroxil
purpose of cephalosporin
good positive activiity and limited gram negative
poor CSF penetration
spectrum of activity for 1st gen cephalosporin
staphylococcus spp.
s.pyogenes (group A strep)
s. agalactiae (group B strep)
viridian’s group strep
PCNs susceptible s.pneumoniae
NO MRSA, MRSE, enterococci spp. and L.monocytogenes
Cephalexin’s activity is poor against
s.pneumoniae ( became resistant)
CoNS ( became resistant)
1st gen cephalorsporin GN coverage
PEK
P. mirabilis
e.coli
k.pneumoniae
1st gen cephalorsporin anaerobes coverage
bacteroids (not b.fragilis)
clostridium (excludes c.diff)
peptostreptococcus
prevotella
fusbacterium
cutibacterium
cefaclor
ceclor
cefuroxime
ceftin , zinacef
cefoxitin*
mofoxin
cefprozil
cefzil
2nd gen cephalosporins purpose
too groups true cephalosporins and cepamycins with enhanced GN
Spectrum of activity of for cephalosporins , GP
less staph
staphylococcus spp.
s.pyogenes (group A strep)
s. agalactiae (group B strep)
viridian’s group strep
PCNs susceptible s.pneumoniae
NO MRSA, MRSE, enterococci spp. and L.monocytogenes
Spectrum of activity of for cephalosporins , GN
enhanced
HNPEKM
h.influenzaie
neisseria
p.mirabolis
e.coli
k.pnemoniae
m.catarrhil
Spectrum of activity of for cephalosporins , anaerobes
clostirum spp.
peptostreptoccous spp.
bacteroids spp
provotella spp
funsobacterium spp
does cefoxitin and cefeton
borreliea burgdorferi
Spectrum of activity of for cephalosporins CSF
non
Spectrum of activity of for cephalosporins , SE
pCNs
GI N/V/D
disulfiram reactions and coagulupathies (MTT side chain)
