Central Nervous System drugs

Question 1

A way of neuron to regulate other cells by conducting an action potential down the axon of the neuron

Answer 1

Axonal Conduction

Question 2

This impedes the entry of drugs into the brain, due to passage being limited to lipid-soluble agents or via specific transport system. It prevents sudden outburst of brain cells, thus preventing injury

Answer 2

Blood Brain Barrier

Question 3

This is a slow progressive neurodegenerative characterized by tremor, rigidity, postural instability, and slowed movement

Answer 3

Parkinson’s disease

Question 4

Differentiate Potential seizure and Generalized seizure

Answer 4

Both are excitations in which potential seizures undergoes limited spread from the focus to adjacent cortical areas of brain, while Generalized seizure spreads widely throughout both hemispheres of the brain

Question 5

Group of disorders characterized by excessive excitability of neurons in the Central Nervous System

Answer 5

Epilepsy

Question 6

Under CNS Stimulants, this type of drug stimulates the release of norepinephrine and dopamine from the brain and SNS

Answer 6

Amphetamines

Question 7

Study of drugs that alter processes controlled by the nervous system

Answer 7

Neuropharmacology

Question 8

What is Synaptic Transmission?

Answer 8

Process by which information is carried across the gap between neuron and postsynaptic cell

Question 9

Give 4 Mechanisms of Action of Antiepileptic drugs

Answer 9

1. Suppression of Sodium
2. Suppression of Calcium Influx
3. Antagonism of Glutamate
4. Potentiation of GABA

Question 10

This is the most commonly prescribed anticonvulsant drugs. It stabilize nerve cells to keep them from getting overexcited by increasing efflux or decreasing influx of sodium ions

Answer 10

Phenytoin

Question 11

Give the therapeutic level of dosage of Phenytoin, Carbamazepine, and Carboxylic Acid, respectively

Answer 11

1. Phenytoin- 10-20 mcg/ml
2. Carbamazepine- 4-12 mcg/ml
3. Carboxylic Acid- 50-100 mcg/ml

Question 12

An anticonvulsant drug that increases the effects of GABA by binding to a carrier protein and acts as a receptor

Answer 12

Gabapentin

Question 13

An abstinence maintenance drug used as an aversion therapy, in which it helps a person give up a behavior or habit by having them associate it with something unpleasant. This also should not be used concurrently with alcohol

Answer 13

Disulfiram

Question 14

What does GABA stand for?

Answer 14

Gamma-aminobutyric acid

Question 15

Two types of Neuromuscular Blocking drugs

Answer 15

Depolarizing blocking agents and Non-depolarizing blocking drugs

Question 16

A depolarizing blocking drug that acts like acetylcholine but not inactivated by ACHe. This is also a drug of choice for short procedures and for orthopedic manipulations

Answer 16

Succinylcholine

Question 17

Two types of Seizure

Answer 17

Petit mal seizure and Grand mal seizure

Question 18

True or False. Prolonged use of Central Nervous System drugs can decrease its side effects

Answer 18

True, because of the body’s adaptation to the drugs

Question 19

The cornerstone of epilepsy therapy and is the current first‐line treatment for partial onset seizures. It is preferred over phenytoin and phenobarbital for having fewer side effects

Answer 19

Carbamazepine

Question 20

Drugs that relax skeletal muscles by disrupting the transmission of nerve impulses at the motor end plate

Answer 20

Neuromuscular Blocking drugs