Autonomic Nervous System drugs

Question 1

Give the other terms for Adrenergic Agonist, Adrenergic Antagonist, Cholinergic Agonist, and Cholinergic Antagonist, respectively

Answer 1

Sympathomimetic, Sympatholytic, Parasympathomimetic, and Parasympatholytic

Question 2

True or False. Parasympatholytic produce effects of Parasympathetic Nervous System

Answer 2

False. Parasympatholytics inhibits PNS, thus producing effects of Sympathetic Nervous System

Question 3

Name the receptors of Adrenergic drugs

Answer 3

Alpha 1, Alpha 2, Beta 1, Beta 2

Question 4

Enumerate the 4 Autonomic Nervous System drugs

Answer 4

1. Adrenergic Agonist
2. Adrenergic Antagonist
3. Cholinergic Agonist
4. Cholinergic Antagonist

Question 5

What are Catecholamines and Non-Catecholamines? Differentiate.

Answer 5

Catecholamines and Non-Catecholamines are a category of Adrenergic Agonists based on chemical structures. Their difference is that Catecholamines has a catechol ring and amines (proteins), while Non-Catecholamines has no catechol ring

Question 6

Give 5 examples of Adrenergic Antagonist drugs

Answer 6

Prazosin, Propranolol, Timolol, Terazosin, Pindolol

Question 7

True or False. In Indirect Acting of Cholinergic Agonist, drug binds with Acetylcholinesterase (AChE), so natural produced Acetylcholine (Ach) will not be degraded by the enzyme and can fit into the receptor

Answer 7

True

Question 8

Give the receptors of Cholinergic Agonist

Answer 8

Muscarinic and Nicotinic

Question 9

What test is used to help confirm the diagnoses between myasthenia crisis and cholinergic crisis?

Answer 9

Tensilon Test

Question 10

What are the adverse reactions of cholinergic agonist dugs?

Answer 10

DUMBBELS
D-Diarrhea, U-Urination, M-Miosis & Muscle weakness, B-Bronchorrhea, B-Bronchospasms, E-Emesis, L-Lacrimation, S-Sweating

Question 11

What are the adverse effects of anticholinergic drugs/cholinergic antagonist?

Answer 11

ABCDS
A-Agitation, B-Blurred Vision, C-Constipation, Confusion, D-Dry Mouth, S-Statis of urine and sweating.

Question 12

What are the neurotransmitters of Preganglionic and Postganglionic fibers?

Answer 12

All preganglionic neurotransmitter are Acetylcholine and all Postganglionic neurotransmitter are Acetylcholine and Norepinephrine.

Question 13

The 5 steps in Synaptic Transmission

Answer 13

1. Synthesis of Neurotransmitter
2. Storage of Neurotransmitter
3. Release of Neurotransmitter
4. Action at the Receptor
5. Termination of Synaptic Transmission

Question 14

3 ways to terminate the Synaptic Transmission

Answer 14

Reuptake, Enzymatic degradation, Diffusion

Question 15

Brief explanation of the Receptor Theory

Answer 15

Drugs act through receptors by binding to the receptors to initiate a response or prevent a response

Question 16

This is a cholinergic enzyme that terminates neuronal transmission and signaling between synapses to prevent ACh dispersal and activation of nearby receptors

Answer 16

Acetylcholinesterase

Question 17

This contains receptors that receives neurotransmitters

Answer 17

Postsynaptic cell

Question 18

These are chemicals produced by CNS and ANS to communicate with each other

Answer 18

Neurotransmitter

Question 19

True or False. Sympatholytics produce effects of Parasympathetic Nervous System

Answer 19

True. Sympatholytic inhibits SNS, thus producing effects of PNS

Question 20

If Sympathetic Nervous System is for Fight or Flight Response, Parasympathetic Nervous System is for____

Answer 20

Rest and Digest