Central Nervous System drugs Flashcards
The study of drugs that alter processes controlled by the nervous system
Neuropharmacology
There are two basic steps in the process by which the neuron influences the behavior of the postsynaptic cell.
1 Axonal conduction
2 Synaptic transmission
It is the process of conducting an action potential down the axon of the neuron.
Axonal conduction
It is a process by which information is carried across the gap between the neuron and the postsynaptic cell.
Synaptic transmission
What is the definition of the Blood-Brain Barrier?
The separation of the circulating blood and the brain extracellular fluid (CSF) Cerebrospinal fluid in the CNS. It occurs along all capillaries and consists of tight junctions around the capillaries that do not exist in normal circulation.
a progressive neurodegenerative condition caused by insufficient quantities of the neurotransmitter Dopamine in the brain, this deficiency causes motor and non-motor symptoms.
Parkinson’s Disease
a drug that increases the activity of a neuromodulator.
Agonist
It is the therapeutic agents that are commonly used in the treatment of Parkinson’s disease (PD).
Dopamine Agonist
Drug that block receptors for ACh (Acetylcholine)
Anticholinergic agents
Patients who develop a physical dependence on a drug will experience withdrawal syndrome when the drug is stopped. Intoxication is a condition that results in disturbances in the level of consciousness, cognition, perception, judgment, behavior, and other psycho-physiologic functions.
Physical dependence - Dependence describes physical need for the drug such that when the drug is stopped, withdrawal symptoms occur. Misuse refers to using a drug or substance to
excess.
Intoxication is a state of being influenced by a drug or other substance and may be a very
small amount in the drug-naïve person or a potentially lethal amount in the chronic user. This
person has developed tolerance to alcohol and is able to have a potentially lethal amount
without severe effects. Addiction describes continued involvement in an activity despite the
substantial harm it causes.
Tolerance - refers to a decrease in drug effects with repeated use.
What are some core symptoms of ADHD in a child?
Difficulty focusing, considerable daydreaming, forgetfulness, squirming or fidgeting, excessive talking, unnecessary risk taking, impatience, difficulty socializing.
What are the functions of the Blood-Brain Barrier
- Protects the brain from “foreign substances” in the blood that may injure the brain.
- Protects the brain from neurotransmitters in the rest of the body.
- Maintains a constant environment for the brain.
What are the 3 receptor theories that cause schizophrenia?
Dopamine blockade
Serotonin blockade
Glutamate
It can thin the blood (prevents platelets from aggregating) and can cause GI bleeds and upsets. What drug is this?
Aspirin
