Autonomic Nervous System drugs Flashcards
Pupil Dilation
Sympathetic
Increases heart rate
Sympathetic
Increases Peristalsis
Parasympathetic
Decreases Heart Rate
Parasympathetic
Constricts blood vessels
Sympathetic
Dilates blood vessels
Parasympathetic
Relaxes uterine muscles
Sympathetic
Increases salivation
Parasympathetic
Activates receptor by binding to that receptor
Agonist
Binds to receptor and prevents agonist from stimulating it
Antagonist
Agonist properties
affinity, intrinsic activity, effect
What is Receptor Theory?
The idea that drugs act by binding to receptors, the application of receptor models to explain drug behaviour.
Effects of beta-1 agonists?
Increase rate and force of contraction of the heart
Bind to receptors found presynaptically to decrease the amount of norepinephrine release.
Basically, these drugs decrease sympathetic outflow.
Therefore, you will see a decrease in vasoconstriction. This results in a drop in blood pressure/hypotension and can also cause bradycardia
Receptors: Alpha 2
Increases the heart rate and force of contraction, increases renin secretion which increases blood pressure.
Beta _ receptors are located in the kidney but primarily in the heart. When stimulated, these receptors increase myocardial contractility and heart rate.
Negative effect: dysthymias, angina
Beta 1
Effects of beta-2 agonists?
Bronchodilation, vasodilation, relaxation of visceral smooth muscle (GIT, bladder, and uterus), glycogenolysis, muscle tremor
Carries info from the outside/structures to be processed; from the PNS (Peripheral Nervous System) to the CNS (Central Nervous System)
Afferent/Sensory
Carries info from the inside to the outside/structures to command or control them, from the CNS (Central Nervous System) to the PNS (Peripheral Nervous System)
Efferent/Motor
Direct-Acting drugs fall into two general categories _____ and ______.
Selective & Non-selective
What division of the PNS is voluntary and controls skeletal muscles?
The somatic nervous system is voluntary and controls skeletal muscle.
What division is involuntary and controls smooth muscle, cardiac muscle, and glands?
The autonomic/visceral nervous system is involuntary and controls involuntary muscles (cardiac and smooth muscle) and glands.
