Central Alpha-2 Adrenergic Agonist

Question 1

MOA

Answer 1

Decrease NE release from the brain => decrease sympathetic => decrease BP

Question 2

Catapress

• Dose

Answer 2

Clonidine

• Catapress: PO 0.1-0.6 mg/d - QD, BID, TID

Question 3

Wytensin

Answer 3

Quanabenz

Question 4

Tenex

Answer 4

Guanfacine

Question 5

Aldomet

Answer 5

Methyldopa

• Use in preg, preeclampsia

Question 6

ADEs of Alpha 2 Agonists

Answer 6

• Sedation
• *Dry mouth
• *Constipation
• Fatigue
• Sexual dysfunction
• *Orthostasis
• Decrease mental concentration
• *Rebound HTN
• Bradycardia
• Depression

Question 7

Additional ADEs of Methyldopa

Answer 7

• Hepatitis
• Hemolytic anemia
• Colitis
• Drug induce lupus

Question 8

Kapvay

Answer 8

Clinidine ER for ADHD

Question 9

Duraclon

Answer 9

Clinidine Epidural

Question 10

Nexiclon XR

• Form

Answer 10

Clonidine

• Nexiclon XR: QD dosing in both suspension and tablet

Question 11

Catapres TTS

• Form

Answer 11

Clonidine

• Catapres TTS: 0.1, 0.2, 0.3 mg/24H: 1 patch/week