Alpha 1 - Adrenergic Blockers

Question 1

Cardura

• Indication

Answer 1

Doxazosin

• BPH, HTN
• HTN: 1mg QD. Max 16 mg QD
• BPH: start 1mg QD. Titrate to max 8mg QD

Question 2

Hytrin

• Indication

Answer 2

Terazosin

• BPH, HTN
• HTN: 1mg HS - 20mg QD/BID
• BPH: 1 mg HS. Max 10 mg QD

Question 3

Minipress

• Indication

Answer 3

Prazosin

• HTN only
• HTN: 1-20mg BID/TID

Question 4

Cardura XR

• Indication

Answer 4

Doxazosin ER

• BPH only
• BPH: 4mg titrate to max 8mg QD in 3-4 wks

Question 5

Flomax

• Indication

Answer 5

Tamsulosin

• BPH
• BPH 0.4 - 0.8mg QD 30 min after same meal

Question 6

Uroxatral

• Indication

Answer 6

Alfuzosin ER

• BPH
• BPH: 10 mg QD (after same meal each day). SWALLOW WHOLE.
• No need to titrate
• Caution w/ CrCl

Question 7

Rapaflo

• Indication

Answer 7

Silodosin

• BPH
• BPH: 8 mg QD w/ meal. No titrate dose needed
• CrCl 30-50mL/min: 4mg QD.
• CI in CrCl

Question 8

MOA of Alpha 1 Blockers

Answer 8

• Blockage of alpha 1 - induced vasoconstriction (onset of action is about 7-14 days)
• Decrease afterload
• Decrease total cholesterol: Increase HDL, decrease TG, and decrease LDL

Question 9

ADEs of Alpha 1 Blockers

Answer 9

• 1st dose phoenomenon: sig orthostatic hypotension

- Can cause floppy iris syndrome

Question 10

CI of Alpha 1 Blockers

Answer 10

• Prostate cancer (masks symptoms)

- Serious HYPOTN if use with ED drugs

Question 11

Alpha 1 Blockers that are CI with CYP3A4 Inhibitors (ketoconazole, itraconazole, and ritonavir)

Answer 11

• Alfuzosin ER - Uroxatral

- Silodosin - Rapaflo

Question 12

Cialis

Adcirca

Answer 12

Tadalafil

Question 13

Levitra

Answer 13

Vardenafil

Question 14

Viagra

Revatio

Answer 14

Sildenafil

Question 15

Stendra

Answer 15

Avanafil