Cellular substage: leukocyte recruitment and activation

Question 1

What are the 4 stages of leukocyte recruitment & activation?

Answer 1

1. Chemoattraction
2. Rolling
3. Stable Adhesion
4. Transmigration

Question 2

Chemoattraction: step 1
? in affected tissue release ?

Answer 2

Macrophages in affected tissue release pro-inflammatory cytokines

Question 3

Chemoattraction: step 2
? recruit ?

Answer 3

Cytokines signaling recruit leukocytes

Question 4

Chemoattraction: step 3
Triggers ? to express ? known as ?

Answer 4

Triggers endothelial cells to express cellular adhesion molecules known as selectins

Question 5

Chemoattraction: step 4
? and ? expressed on ?

Answer 5

P-selecting and E selectin expressed on endothelial cells

Question 6

Chemoattraction: step 5
? have ?enabling binding to ? on ?

Answer 6

Selectins have carbohydrate recognition motifs enabling binding to glycans on leukocytes