Acute Inflammation: Mediators Flashcards
1
Q
What are the mediators of acute IF?
A
cell derived and plasma derived mediators
2
Q
What are the types of cell derived mediators? What is their role?
A
histamine and serotonin.
causes dilation and increased permeability of vessels
3
Q
What are the types of plasma derived mediators?
A
Kinins, fibrin strands and complement cascade
4
Q
What do plasma derived mediators exist as and how are they activated?
A
exist as precursors, activated by proteases
5
Q
What is the role of kinins? 2
A
increase vessel permeability and stimulate pain receptors
6
Q
What is the role of fibrin strands? 3
A
enable clotting, trap exudates and foreign bodies
7
Q
What is the role of complement cascade? 3
A
cause vessel dilation, promotes leukocyte chemotaxis, enhances phagocytosis
