Cellular Homeostasis Flashcards
Where are glut 1 receptos found?
everywhere but mainly in the brain and rbc
where are glut 2 receptors found?
liver and pancrease, this is how beta cells know how to secrete insulin
Where are glut 3 receptors found?
neurons
where are glut 4 receptors founf?
skeletal muscle tissue, heart, and adipose tissue
Which glut R is regulated by insulin?
glut 4
How many ATP are made from 1 molecule of glucose
34-36
what is the ultimate product of anaerobic glycolysis?
2 lactate and 2 NAD+
3 suppliers of glucose?
diet
glycogenolysis
gluconeogenesis
Fanconi Bickel Syndrome is caused by
inherited deficiency of glut 2 receptors in the liver, pancreas, and proximal renal tubule- so your body doesnt know to secrete insulin and stimulate the GLUT 4 in muscle and fat so the clearing of excess blood glucose
S/S of Fanconi Bickel Syndrome
hepatomegaly, stunted growth, hyperglycemia after a mean and hypoglycemia during fasting
Why does Fanconi Bickel Syndrome cause hepatomegaly?
because glycogen stored in the liver cannot get out
Rx for Fanconi Bickel?
ingestion of small meals throughout the day and supplementation of vitamin D (proximal tubular nephropathy prevents uptake and can lead to rickets)
Is the Glut 2 transporter uni or bi directional?
bidirectional depending on the concentration
High—— low—— system
capacity, affinity
How does gluoce sensing by Glut 2 work?
glucose is taken into the cell and ATP is made from it. Rishe in ATP closes K+ channels causing depolarization which opens voltage gated Ca++ channels. Influx of Ca++ triggers release of already synthesized insulin molecules and the synthesis of more insulin in a slow release pathway
