Cellular Aberration Flashcards
Disease condition wherin the NORMAL cells becomes ABNORMAL and PROLIFERATES abnormally.
Cancer
Incidence of Cancer
-Cancer affects every age group though most cancer and cancer deaths occur in people older than 65 years old.
-Cancer ranks 3rd as the cause of morbidity in the Philippines
-Highest incidence of all cancer is Prostate Cancer
-Highest cancer incidence in males in order of frequency: Prostate, Lung, and Colorectal
-Highest cancer incidence in females in order of frequency: Breast, Lung, and Colorectal
Branch of medicine that deals with the study, detection, treatment, and management of cancer.
Oncology
Interphase
G1 – RNA & Protein Synthesis
S – DNA Synthesis
G2 – Pre mitosis
Mitosis Phase
Actual cell division
NEO
New
PLASIA
Growth
TROPHY
Size
OMA
Benign Tumor
Stasis
Location
A
Absence
ANA
Lack
Hyper
Excessive/increase
META
Change
DYS
Bad, impaired
SARCOMA
Malignant tumor in connective tissues
CARCINOMA
Malignant tumor in epithelial tissues
BLASTOMA
Malignant tumor that starts in immature cell
Immune System (low)
Cancer cells are already in the body but INACTIVE
Due to stressors:
Cancer cells ACTIVATED
Failure of Immune Response Theory
No cancer cells in the body
Due to exposure to CARCINOGENS:
Cancer cells DEVELOPS
Cell Transformation Theory
Atrophy
Absence/decrease in size
Hypertrophy
Excessive/increase in size
Hyperplasia
Excessive/Increase in growth
Metastasis
Change in location
Dysplasia
impaired growth
anaplasia
absence of growth
neoplasia
new growth
dystrophy
bad size
Types of Carcinogens
-Chemical Carcinogens
-Physical Carcinogens
-Viral Carcinogens
-Dietary Carcinogens
Chemical Carcinogens
Alcoholic beverages
Smoking
Asbestos
Benzene
Arsenic
Pesticides
Sunlight
Physical Carcinogens
Radiation
Chronic Irritation of Tissue – GERD
Viral Carcinogens
Human Papilloma Virus
Genital Herpes
Hepatitis B
Personal Factors Causing Cancer
Immune function
Age
Gender
Genetic risk
Race
Carcinogenesis
- Initiation
- Promotion
- Progression
Carcinogenesis:
Occurs when carcinogen damages DNA
Initiation
Carcinogenesis:
Occurs with additional assaults to the cell
Promotion
Carcinogenesis:
Cell proliferation
Progression
NORMAL CELLS vs CANCER CELLS
MITOSIS
Normal cells: Leads to 2 daughter cells
Cancer Cells: Leads to multiple daughter cells
NORMAL CELLS vs CANCER CELLS:
APPEARANCE
Normal Cells: Homogeneous in size, shape, and growth
Cancer Cells: Larger and grow more rapidly
NORMAL CELLS vs CANCER CELLS:
Apoptosis
Normal Cell: Present
Cancer Cell: Impaired
NORMAL CELLS vs CANCER CELLS:
Growth Pattern
Normal Cell:
Do not invade to adjacent tissue
Cannot grow outside environment
Cell death = Cell birth
Cancer Cell:
Invades to adjacent tissue
Able to migrate to another site
Cell death < Cell birth
Ability of cancer cells to spread from the original site of the tumor to distant organs
Cancer Metastasis
Modes of Metastasis
- Lymphatic Spread
- Hematogenous Spread
(+) Capsule (Well differentiated)
Slow to grow
High survival rate
Growth: Expansion
Affects surrounding tissues
(+) Pain –Due to compression of surrounding tissues.
Ideal Tx: Surgery
Benign
(-) Capsule (Poorly differentiated)
Rapid growing
Low survival rate
Growth: Metastasis / Invasion
Affects other organs
(+) Pain – Due to metastasis
Ideal Tx: Radiation / Chemo
Malignant
A nurse obtains health histories when admitting clients to a medical-surgical unit. With which client should the nurse discuss predisposition genetic testing?
a. Middle-aged woman whose mother died at age 48 of breast cancer
b. Young man who has all the symptoms of rheumatoid arthritis
c. Pregnant woman whose father has sickle cell disease
d. Middle-aged man of Eastern European Jewish ancestry
a. Middle-aged woman whose mother died at age 48 of breast cancer
The nursing instructor explains the difference between normal cells and benign tumor cells. What information does the instructor provide about these cells?
a. Benign tumors grow through invasion of other tissue.
b. Benign tumors have lost their cellular regulation from contact inhibition.
c. Growing in the wrong place or time is typical of benign tumors.
d. The loss of characteristics of the parent cells is called anaplasia.
c. Growing in the wrong place or time is typical of benign tumors.
A nurse has taught a client about dietary changes that can reduce the chances of developing cancer. What statement by the client indicates the nurse needs to provide additional teaching?
a. “Foods high in vitamin A and vitamin C are important.”
b. “I’ll have to cut down on the amount of bacon I eat.”
c. “I’m so glad I don’t have to give up my juicy steaks.”
d. “Vegetables, fruit, and high-fiber grains are important.”
c. “I’m so glad I don’t have to give up my juicy steaks.”
What is the purpose of staging cancer?
To determine specific treatment on specific stage
Cancer in situ (in place)
Stage 0
Cancer is limited in distal origin (Occupies space to surrounding tissues)
(Pain Starts)
Stage 1
Lymph node involvement
(Metastasis Starts)
Stage 2
Spread distal or regional
Stage 3
Wide spread metastasis
> 1st Priority: Pain Management
DOC: Narcotics (Morphine Sulfate)
> 2nd Priority: Spiritual Care
Stage 4
TNM Meaning
Tumor
Node
Metastasis
Tumor Classification
T0: No tumor found
Tis: Tumor in situ
T1: 0-2 cm
T2: 2-5 cm
T3: >5 cm
T4: Tumor has been broken
Tx: Tumor can’t be measured
Node Classification
Nx: Lymph node involvement cannot be assessed
N0: No lymph node involvement
N1: 1-3 nodes involved
N2: 4-6 lymph nodes involved
N3: >7 lymph nodes involved
Metastasis Classfication
M0: No metastasis
M1: Positive metastasis
WARNING SIGNS OF CANCER
Change in Bowel / Bladder Habits (Colon, Bladder)
A sore that does not heal (Skin Cancer)
Unusual bleeding (Leukemia)
Thickening of the lump (Hodgkin/Non Hodgkin)
Indigestion – Feeling bloated but walay mugawas
Obvious change in warts/moles (Skin Cancer)
Nagging cough (Laryngeal, Lung Cancer)
Unexplainable anemia (Leukemia)
Sudden weight loss
Prevention of Cancer Key Points
Prevention is a priority in oncology nursing because at least one third of all cancers are preventable
Cancer is also curable if detected and treated early
PREVENTION TEACHINGS
Reduce or avoid exposure to known or suspected carcinogens
Eat a balanced diet that includes fresh fruits and vegetables, whole grains, and adequate fiber
Limit Alcohol Intake
Participate in regular exercise
Maintain a healthy weight
Obtain adequate rest periods (6-8 hours per night)
Eliminate, reduce, or change the perception of stressors and enhance ability to cope
Have a regular physical exam
TREATMENTS
Oral Therapy
Radiation Therapy
CHImotherapy
D Bone marrow aspiration
Surgery – Most common mode of treatment
Reduces the size of tumor
Relieves obstruction
Targets: Cancer Cells
Radiation Therapy
Types of Radiation Therapy
Internal
External
Types of Internal
Sealed
Unsealed
(+) Container
Implants:
- Cobalt
- Cervical
Sealed
(-) Container
Oral & IV
Unsealed
Brachytherapy
Internal Radiation therapy
(+) Residual Radiation
Flush the CR at least 3 times
Lock the door at all times
Avoid exposure to child and pregnant
Internal Radiation Therapy
Uses beam of light (UV Rays)
S/E: Dermatitis (Temporary)
External
Teletherapy
External
(-) Residual Radiation
External
BETA Rays
Penetrates into the skin
Use: RUBBER GLOVES & LEAD APRON
Internal
GAMMA Rays
Penetrates into the bones
Use: LEAD APRON
External
Factors Affecting Exposure to Radiation
S hielding
T ime
D istance
Private room
Farthest room available
Avoid pregnant & children
Wear lead apron
Handling secretions & discharges:
1. Wear rubber gloves when handling bedpan
2. Flush the toilet at least 3 times
Patient with implants:
1. Bedrest – Flat/Supine position
2. Offer bed pan to maintain bed rest
3. Log roll to turn the patient
4. Patient facing opposite the door
5. Nurse must stand opposite to the implant
6. Sexual activity may resume 3 weeks after removal of implant.
In case of DISLODGE:
1. Pick up with long handled forcep
2. Place implant in LEAD CONTAINER
If not found:
1. Close the door and leave the room
2. Call the radiology department
Shielding