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Pharm Exam 7 > Cell wall inhibitors > Flashcards

Cell wall inhibitors Flashcards

0
Q

Penicillin V

A

Oral stable

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1
Q

Penicillin G

A

Natural penicillin. Potassium- IV, IM. Benzathine- IM depot. Procaine- IM.

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2
Q

Nafcillin

A

Penicillinase resistant, antistaph

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3
Q

Oxacillin

A

Penicillinase resistant, antistaph

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4
Q

Dicloxacillin

A

Penicillinase resistant, antistaph

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5
Q

Methicillin

A

Penicillinase resistant, antistaph. Reserved

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6
Q

Ampicillin

A

Extended spectrum penicillin

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7
Q

Amoxicillin

A

Extended spectrum penicillin

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8
Q

Piperacillin

A

Antipseudomonal penicillin

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9
Q

Ticarcillin

A

Antipseudomonal penicillin

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10
Q

Aztreonam

A

Monobactam - For G- rods (Pseudomonas, Serratia), No G+ or anaerobe effect.
Parenteral, no cross-sensitivity w/ penicillin derivatives
B-lactamase resistant

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11
Q

Imipenem

A

Carbapenem. IV. Broad spec: G+, G- rods, anaerobes
Given w/ Cilastatin-dehydropeptidase inhibitor (inactivation in tubules)
Risk of seizures
Pseudomonal resistance risk, give w/ aminoglycosides

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12
Q

Cilastatin

A

Dehydropeptidase inhibitor. Give w/ Imipenem

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13
Q

Meropenem

A

Carbapenem. IV. Broad spec: G+, G- rods, anaerobes
Pseudomonal resistance risk, give w/ aminoglycoside
Less seizure risk than Iminepem

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14
Q

Ertapenem

A

Carbapenem. IV, IM. Very B-lactamase stable

Broad spec: G+, G-, anaerobes (esp Enterobacteriae)

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15
Q

Doripenem

A

Carbapenem

16
Q

Clavunic acid

A

B-lactamase inhibitor (many not all)
Most active vs plasmid encoded
Weak bactericidal

17
Q

Sulbactam

A

B-lactamase inhibitor (many not all)
Most active vs plasmid encoded
Weak bactericidal

18
Q

Tazobactam

A

B-lactamase inhibitor (many not all)
Most active vs plasmid encoded
Weak bactericidal

19
Q

Vancomycin

A

Bactericidal - inhibits elongation and transpep of peptidoglycan chain
DOC: MRSA, PCN-resistant staph
only G+ spectrum, poor CNS penetration, for PCN allergic pt
Tox: red man syndrome, nephro-, oto-tox w/ aminodlycosides
Usually IV, oral: fo pseudomembranous colitis and super infx

20
Q

Telavancin

A

Bactericidal - inc cell membrane permeability
G+, MRSA, complicated skin infx, last line: nosocomial staph aureus
CI: pregnancy, renal failure

21
Q

Fosfomycin

A

Inhibits - first step in peptidoglycan synth= inhibit CW synth
For uncomplicated UTI (4th/5th line)
Can be combined w/ B-lactams

22
Q

Bacitracin

A

Interferes w/ phospholipid carriers - inhibits CW synth
G+, topical use in combo
Tox: IV -> serious nephrotoxicity

23
Q

Cycloserine

A

Inhibits incorporation of D-alanine in CW (inhibits synth)

Not used anymore b/c CNS tox

24
Q

Daptomycin

A

Liptopeptide, bactericidal, binds to bacterial membrane -> rapid depol
Excreted by kidney, IV
G+
mild tox

Pharm Exam 7 (5 decks)

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