cell stuff Flashcards
predominant cell type 24-48 hours after initial injury in a wound; responsible for phagocytosis of bacteria and wound debris
neutrophils
when do macrophages peak in wound healing?
48-96hrs
protein expressed in melanoma, schwannomas, and neurofibromas
S-100
proinflammatory component of cell wall in gram negative bacteria
lipopolysaccharide
most commoon type of collagen found in a scar
type 1 (most common in the body)
what two unique amino acids are used in collagen synthesis?
hydroxyproline and hydroxylysine
where is type 2 collagen found?
cartilage
where is type 3 collagen found?
blood vessels, fetal skin, uterus
where is type 4 collagen found?
basement membranes
where is type 5 collagen found?
cornea
when during wound healing does maximum collagen accumulate?
3 weeks
four stages of wound healing:
hemostasis, inflammation, proliferation, remodeling
what aspect of collagen provides tensile strength in wounds
covalent cross-linking of lysine
stage of wound healing characterized by increased vascular permeability, migration of cells into the wound by chemotaxis, secretion of cytokines and growth factors, and activation of migrating cells
inflammation stage
stage of wound healing characterized by formation of granulation tissue
proliferation stage
protein complexes that help in cell to cell adhesion
desmosomes
EGFR inhibitor approved for metastatic colorectal cancer:
cetuximab
EGFR inhibitor approved for metastatic NSCLC
erlotinib
Oral kinase inhibitor approved for metastatic melanoma harboring BRAF mutations:
dabrafenib
Most important types of collagen for wound healing
type 1 and 3
Which cytokine is associated with cachexia
TNF alpha
What cells release lactate by glycolysis
skeletal muscle, erythrocytes, leukocytes
Recycling of lactate and pyruvate for gluconeogenesis is called the
Cori cycle
Precursors of gluconeogenesis include
lactate, pyruvate, glycerol, and amino acids
