cell stuff

Question 1

predominant cell type 24-48 hours after initial injury in a wound; responsible for phagocytosis of bacteria and wound debris

Answer 1

neutrophils

Question 2

when do macrophages peak in wound healing?

Answer 2

48-96hrs

Question 3

protein expressed in melanoma, schwannomas, and neurofibromas

Answer 3

S-100

Question 4

proinflammatory component of cell wall in gram negative bacteria

Answer 4

lipopolysaccharide

Question 5

most commoon type of collagen found in a scar

Answer 5

type 1 (most common in the body)

Question 6

what two unique amino acids are used in collagen synthesis?

Answer 6

hydroxyproline and hydroxylysine

Question 7

where is type 2 collagen found?

Answer 7

cartilage

Question 8

where is type 3 collagen found?

Answer 8

blood vessels, fetal skin, uterus

Question 9

where is type 4 collagen found?

Answer 9

basement membranes

Question 10

where is type 5 collagen found?

Answer 10

cornea

Question 11

when during wound healing does maximum collagen accumulate?

Answer 11

3 weeks

Question 12

four stages of wound healing:

Answer 12

hemostasis, inflammation, proliferation, remodeling

Question 13

what aspect of collagen provides tensile strength in wounds

Answer 13

covalent cross-linking of lysine

Question 14

stage of wound healing characterized by increased vascular permeability, migration of cells into the wound by chemotaxis, secretion of cytokines and growth factors, and activation of migrating cells

Answer 14

inflammation stage

Question 15

stage of wound healing characterized by formation of granulation tissue

Answer 15

proliferation stage

Question 16

protein complexes that help in cell to cell adhesion

Answer 16

desmosomes

Question 17

EGFR inhibitor approved for metastatic colorectal cancer:

Answer 17

cetuximab

Question 18

EGFR inhibitor approved for metastatic NSCLC

Answer 18

erlotinib

Question 19

Oral kinase inhibitor approved for metastatic melanoma harboring BRAF mutations:

Answer 19

dabrafenib

Question 20

Most important types of collagen for wound healing

Answer 20

type 1 and 3

Question 21

Which cytokine is associated with cachexia

Answer 21

TNF alpha

Question 22

What cells release lactate by glycolysis

Answer 22

skeletal muscle, erythrocytes, leukocytes

Question 23

Recycling of lactate and pyruvate for gluconeogenesis is called the

Answer 23

Cori cycle

Question 24

Precursors of gluconeogenesis include

Answer 24

lactate, pyruvate, glycerol, and amino acids

Question 25

Three cytokines most responsible for acute asthma exacerbations:

Answer 25

IL4, IL5, IL13